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Aggression and polymorphisms in AR, DAT1, DRD2, and COMT genes in Datoga pastoralists of Tanzania.

Butovskaya ML, Vasilyev VA, Lazebny OE, Suchodolskaya EM, Shibalev DV, Kulikov AM, Karelin DV, Burkova VN, Mabulla A, Ryskov AP - Sci Rep (2013)

Bottom Line: The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga.Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger.At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Cross-Cultural Psychology and Human Ethology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, 119991, Russia [2].

ABSTRACT
The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga. Buss and Perry's Aggression Questionnaire was used to measure aggression. The number of CAG repeats in the AR gene was negatively correlated with physical aggression, anger, and hostility. Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger. At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility. These data suggest a probable link between physical aggression and direct fitness caused by strong sexual selection in Datoga men.

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Related in: MedlinePlus

The distributions of the physical aggression (A), anger (B), and hostility (C) subscales as correlated with the number of CAG repeats in the AR gene.The ordinate numbers designate the self-rated scores according to the subscales of Buss and Perry's Aggression Questionnaire.
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f1: The distributions of the physical aggression (A), anger (B), and hostility (C) subscales as correlated with the number of CAG repeats in the AR gene.The ordinate numbers designate the self-rated scores according to the subscales of Buss and Perry's Aggression Questionnaire.

Mentions: We performed a simple regression analysis to test the single-gene effect of the AR gene on aggression and detected significant effects of the AR CAG polymorphism on physical aggression and hostility, with carriers of smaller numbers of CAG repeats showing a higher rating (Tables 2, and Figs. 1a,b,c). The results for AR and the self-rated scores for anger exhibited a trend in the same direction (Table 2). Therefore, our data show that men with fewer CAG repeats behave more aggressively than their fellow males with a greater number of AR CAG repeats.


Aggression and polymorphisms in AR, DAT1, DRD2, and COMT genes in Datoga pastoralists of Tanzania.

Butovskaya ML, Vasilyev VA, Lazebny OE, Suchodolskaya EM, Shibalev DV, Kulikov AM, Karelin DV, Burkova VN, Mabulla A, Ryskov AP - Sci Rep (2013)

The distributions of the physical aggression (A), anger (B), and hostility (C) subscales as correlated with the number of CAG repeats in the AR gene.The ordinate numbers designate the self-rated scores according to the subscales of Buss and Perry's Aggression Questionnaire.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3818681&req=5

f1: The distributions of the physical aggression (A), anger (B), and hostility (C) subscales as correlated with the number of CAG repeats in the AR gene.The ordinate numbers designate the self-rated scores according to the subscales of Buss and Perry's Aggression Questionnaire.
Mentions: We performed a simple regression analysis to test the single-gene effect of the AR gene on aggression and detected significant effects of the AR CAG polymorphism on physical aggression and hostility, with carriers of smaller numbers of CAG repeats showing a higher rating (Tables 2, and Figs. 1a,b,c). The results for AR and the self-rated scores for anger exhibited a trend in the same direction (Table 2). Therefore, our data show that men with fewer CAG repeats behave more aggressively than their fellow males with a greater number of AR CAG repeats.

Bottom Line: The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga.Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger.At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Cross-Cultural Psychology and Human Ethology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, 119991, Russia [2].

ABSTRACT
The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga. Buss and Perry's Aggression Questionnaire was used to measure aggression. The number of CAG repeats in the AR gene was negatively correlated with physical aggression, anger, and hostility. Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger. At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility. These data suggest a probable link between physical aggression and direct fitness caused by strong sexual selection in Datoga men.

Show MeSH
Related in: MedlinePlus