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The healing effect of licorice (Glycyrrhiza glabra) on Helicobacter pylori infected peptic ulcers.

Rahnama M, Mehrabani D, Japoni S, Edjtehadi M, Saberi Firoozi M - J Res Med Sci (2013)

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, School of Pharmacy, Shiraz, Iran.

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Initial treatment failure due to resistance requires alternative strategies, like a quadruple therapy, which adds a bismuth colloid, e.g., bismuth subsalicylate... Herbal medicine has been opened its way in therapy of gastric ulcer, among them, licorice (liquorice or sweet wood) was shown to have anti H. pylori effects derived from the roots and stolons of Glycyrrhiza species... This study aims to compare the quadruple therapy of amoxicillin, metronidazole, omeprazole, and bismuth sub nitrate with the same treatment while licorice is replaced by the bismuth sub nitrate in peptic ulcer patients... The first group received amoxicillin (500 mg, 3 times/day after diet for 15 days), metronidazole (250 mg, 4 times/day after diet for 15 days), omeprazole (20 mg, 2 times/day ½ h before the diet for 30 days) and bismuth sub nitrate (500 mg, 3 times/day ½ h before the diet for 30 days)... After 1 month of therapy, all patients underwent endoscopy again providing a biopsy for histological study to determine the peptic ulcer healing rate and urease breath test to denote the extent of H. pylori eradication... The healing of peptic ulcer was visible in 95% of Group 1 and 70% of Group 2... Pathologically, in Group 1, the eradicative effect of licorice against H. pylori was 70% in comparison to Group 2 (45%)... These figures based on the urease breath test results were 55% and 40% respectively... In 80% of Group 1, a reduction in pain was noticed when compared with Group 2 (70%)... In Figure 2, the arrow denotes to the H. pylori infection (a shows the epithelial cells and b the gastric gland; H and E, ×200)... Figure 3 demonstrates the absence of H. pylori infection and the presence of inflammatory cells in the tissue and the healing effect of licorice(indicates epithelial cells and b the necrosis region; H and E, ×100)... Fukai et al. reported weak healing effects for licorice in peptic ulcer too... Our findings showed that licorice could be suggested as a replacement in treatment for quadruple therapy when this regimen is not available while licorice has a low-cost, highly tolerable and with minimal side-effects.

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(a) Epithelial cells, (b) gastric gland. Arrow: Helicobacter pylori (H and E, ×200)
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Figure 2: (a) Epithelial cells, (b) gastric gland. Arrow: Helicobacter pylori (H and E, ×200)

Mentions: Figure 1 shows an ulcer in the antrum of patients before treatment and the presence of inflammatory cells (a) (H and E, ×30). In Figure 2, the arrow denotes to the H. pylori infection (a shows the epithelial cells and b the gastric gland; H and E, ×200). Figure 3 demonstrates the absence of H. pylori infection and the presence of inflammatory cells in the tissue and the healing effect of licorice(indicates epithelial cells and b the necrosis region; H and E, ×100).


The healing effect of licorice (Glycyrrhiza glabra) on Helicobacter pylori infected peptic ulcers.

Rahnama M, Mehrabani D, Japoni S, Edjtehadi M, Saberi Firoozi M - J Res Med Sci (2013)

(a) Epithelial cells, (b) gastric gland. Arrow: Helicobacter pylori (H and E, ×200)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3818629&req=5

Figure 2: (a) Epithelial cells, (b) gastric gland. Arrow: Helicobacter pylori (H and E, ×200)
Mentions: Figure 1 shows an ulcer in the antrum of patients before treatment and the presence of inflammatory cells (a) (H and E, ×30). In Figure 2, the arrow denotes to the H. pylori infection (a shows the epithelial cells and b the gastric gland; H and E, ×200). Figure 3 demonstrates the absence of H. pylori infection and the presence of inflammatory cells in the tissue and the healing effect of licorice(indicates epithelial cells and b the necrosis region; H and E, ×100).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, School of Pharmacy, Shiraz, Iran.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Initial treatment failure due to resistance requires alternative strategies, like a quadruple therapy, which adds a bismuth colloid, e.g., bismuth subsalicylate... Herbal medicine has been opened its way in therapy of gastric ulcer, among them, licorice (liquorice or sweet wood) was shown to have anti H. pylori effects derived from the roots and stolons of Glycyrrhiza species... This study aims to compare the quadruple therapy of amoxicillin, metronidazole, omeprazole, and bismuth sub nitrate with the same treatment while licorice is replaced by the bismuth sub nitrate in peptic ulcer patients... The first group received amoxicillin (500 mg, 3 times/day after diet for 15 days), metronidazole (250 mg, 4 times/day after diet for 15 days), omeprazole (20 mg, 2 times/day ½ h before the diet for 30 days) and bismuth sub nitrate (500 mg, 3 times/day ½ h before the diet for 30 days)... After 1 month of therapy, all patients underwent endoscopy again providing a biopsy for histological study to determine the peptic ulcer healing rate and urease breath test to denote the extent of H. pylori eradication... The healing of peptic ulcer was visible in 95% of Group 1 and 70% of Group 2... Pathologically, in Group 1, the eradicative effect of licorice against H. pylori was 70% in comparison to Group 2 (45%)... These figures based on the urease breath test results were 55% and 40% respectively... In 80% of Group 1, a reduction in pain was noticed when compared with Group 2 (70%)... In Figure 2, the arrow denotes to the H. pylori infection (a shows the epithelial cells and b the gastric gland; H and E, ×200)... Figure 3 demonstrates the absence of H. pylori infection and the presence of inflammatory cells in the tissue and the healing effect of licorice(indicates epithelial cells and b the necrosis region; H and E, ×100)... Fukai et al. reported weak healing effects for licorice in peptic ulcer too... Our findings showed that licorice could be suggested as a replacement in treatment for quadruple therapy when this regimen is not available while licorice has a low-cost, highly tolerable and with minimal side-effects.

No MeSH data available.