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Orbital solitary fibrous tumor: A rare clinicopathologic correlation and review of literature.

Ali MJ, Honavar SG, Naik MN, Vemuganti GK - J Res Med Sci (2013)

Bottom Line: Orbital solitary fibrous tumor (SFT) is a rare tumor and orbits are a very uncommon site.It is mostly noted to arise from mesenchymal structures like pleura and peritoneum.We describe clinical presentations, radiological and operative findings, and pathological features of a patient with orbital SFT along with a brief review of literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Ocular Oncology Service, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, Andhra Pradesh, India.

ABSTRACT
Orbital solitary fibrous tumor (SFT) is a rare tumor and orbits are a very uncommon site. It is mostly noted to arise from mesenchymal structures like pleura and peritoneum. The diagnosis of orbital SFT cannot be made with certainty on clinical or radiological evaluation alone and requires immunohistochemical studies for confirmation. Orbital SFT's usually show an indolent clinical course and a complete cure can usually be achieved with complete resection. We describe clinical presentations, radiological and operative findings, and pathological features of a patient with orbital SFT along with a brief review of literature.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemistry microphotographs showing diffuse and strong positivity with BCL-2 (a), Vimentin positivity (b), Reticulin negativity (c), and smooth muscle actin negativity (d)
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Figure 2: Immunohistochemistry microphotographs showing diffuse and strong positivity with BCL-2 (a), Vimentin positivity (b), Reticulin negativity (c), and smooth muscle actin negativity (d)

Mentions: Gross examination showed a pinkish mass whose cut section was pinkish-grey with multiple areas of hemorrhage. Microscopic examination showed an encapsulated tumor with cellular and cystic areas. Spindle shaped tumor cells arranged in whorls with minimal atypia, moderate nuclear pleomorphism and inconspicuous nucleoli were noted [Figure 1c]. The tumor showed vessels of varying caliber, dilated to compressed, lined by flattened endothelium [Figure 1c]. However, stag horn channels and giant cells were not noted. Immunohistochemistry showed tumor cells showing a positive staining with CD99 [Figure 1d], strongly positive for CD34 and BCL-2 [Figure 2a] and background positivity for vimentin [Figure 2b]. However, reticulin staining [Figure 2c] and smooth muscle actin (SMA) were negative [Figure 2d]. The morphological and immunohistochemical features were consistent with a diagnosis of orbital SFT.


Orbital solitary fibrous tumor: A rare clinicopathologic correlation and review of literature.

Ali MJ, Honavar SG, Naik MN, Vemuganti GK - J Res Med Sci (2013)

Immunohistochemistry microphotographs showing diffuse and strong positivity with BCL-2 (a), Vimentin positivity (b), Reticulin negativity (c), and smooth muscle actin negativity (d)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3818628&req=5

Figure 2: Immunohistochemistry microphotographs showing diffuse and strong positivity with BCL-2 (a), Vimentin positivity (b), Reticulin negativity (c), and smooth muscle actin negativity (d)
Mentions: Gross examination showed a pinkish mass whose cut section was pinkish-grey with multiple areas of hemorrhage. Microscopic examination showed an encapsulated tumor with cellular and cystic areas. Spindle shaped tumor cells arranged in whorls with minimal atypia, moderate nuclear pleomorphism and inconspicuous nucleoli were noted [Figure 1c]. The tumor showed vessels of varying caliber, dilated to compressed, lined by flattened endothelium [Figure 1c]. However, stag horn channels and giant cells were not noted. Immunohistochemistry showed tumor cells showing a positive staining with CD99 [Figure 1d], strongly positive for CD34 and BCL-2 [Figure 2a] and background positivity for vimentin [Figure 2b]. However, reticulin staining [Figure 2c] and smooth muscle actin (SMA) were negative [Figure 2d]. The morphological and immunohistochemical features were consistent with a diagnosis of orbital SFT.

Bottom Line: Orbital solitary fibrous tumor (SFT) is a rare tumor and orbits are a very uncommon site.It is mostly noted to arise from mesenchymal structures like pleura and peritoneum.We describe clinical presentations, radiological and operative findings, and pathological features of a patient with orbital SFT along with a brief review of literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Ocular Oncology Service, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, Andhra Pradesh, India.

ABSTRACT
Orbital solitary fibrous tumor (SFT) is a rare tumor and orbits are a very uncommon site. It is mostly noted to arise from mesenchymal structures like pleura and peritoneum. The diagnosis of orbital SFT cannot be made with certainty on clinical or radiological evaluation alone and requires immunohistochemical studies for confirmation. Orbital SFT's usually show an indolent clinical course and a complete cure can usually be achieved with complete resection. We describe clinical presentations, radiological and operative findings, and pathological features of a patient with orbital SFT along with a brief review of literature.

No MeSH data available.


Related in: MedlinePlus