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Regeneration of toxigenic Pasteurella multocida induced severe turbinate atrophy in pigs detected by computed tomography.

Magyar T, Donkó T, Repa I, Kovács M - BMC Vet. Res. (2013)

Bottom Line: Atrophic rhinitis is a widely prevalent infectious disease of swine caused by Bordetella bronchiseptica and Pasteurella multocida.The course of the disease is considered to be different depending on the principal aetiological agents distinguishing B. bronchiseptica induced non-progressive and toxigenic P. multocida produced progressive forms.Computed tomography has further been verified to be a useful tool to examine the pathological events of atrophic rhinitis in a longitudinal manner.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary. magyar.tibor@agrar.mta.hu.

ABSTRACT

Background: Atrophic rhinitis is a widely prevalent infectious disease of swine caused by Bordetella bronchiseptica and Pasteurella multocida. The course of the disease is considered to be different depending on the principal aetiological agents distinguishing B. bronchiseptica induced non-progressive and toxigenic P. multocida produced progressive forms. In order to compare the pathological events of the two forms of the disease, the development of nasal lesions has longitudinally been studied in pigs infected by either B. bronchiseptica alone or B. bronchiseptica and toxigenic P. multocida together using computed tomography to visualise the nasal structures.

Results: B. bronchiseptica infection alone caused moderately severe nasal turbinate atrophy and these lesions completely regenerated by the time of slaughter. Unexpectedly, complete regeneration of the bony structures of the nasal cavity was also observed in pigs infected by B. bronchiseptica and toxigenic P. multocida together in spite of seeing severe turbinate atrophy in most of the infected animals around the age of six weeks.

Conclusions: B. bronchiseptica mono-infection has been confirmed to cause only mild to moderate and transient lesions, at least in high health status pigs. Even severe turbinate atrophy induced by B. bronchiseptica and toxigenic P. multocida combined infection is able to be reorganised to their normal anatomical structure. Computed tomography has further been verified to be a useful tool to examine the pathological events of atrophic rhinitis in a longitudinal manner.

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Sequential computed tomography scans of pig No. 4 in Experiment 2. Pig No. 4 was infected with B. bronchiseptica at the age of 4 days (D0) and P. multocida at the age of 8 days (D4). Complete regeneration of the nasal turbinates was observed although severe turbinate atrophy (nasal lesion score 15) was seen from Day 18 to Day 32.
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Figure 3: Sequential computed tomography scans of pig No. 4 in Experiment 2. Pig No. 4 was infected with B. bronchiseptica at the age of 4 days (D0) and P. multocida at the age of 8 days (D4). Complete regeneration of the nasal turbinates was observed although severe turbinate atrophy (nasal lesion score 15) was seen from Day 18 to Day 32.

Mentions: In the B. bronchiseptica - P. multocida infected group, 12 out of the 14 piglets had 12 or higher NLS by the time of D25 indicating rapidly developing and severe turbinate atrophy in the whole group. Interestingly, most of the pigs showed unexpected signs of reparation noticed from D60 and at the time of the termination of the study (D128) 7 out of the 14 pigs had a score of ≤3. Figure 3 demonstrates an example of such a complete regeneration of turbinate atrophy with a score of 15 on D25 and 32. Figure 4 illustrates the only case when the severe TA and NSD lasted until the termination of the study.


Regeneration of toxigenic Pasteurella multocida induced severe turbinate atrophy in pigs detected by computed tomography.

Magyar T, Donkó T, Repa I, Kovács M - BMC Vet. Res. (2013)

Sequential computed tomography scans of pig No. 4 in Experiment 2. Pig No. 4 was infected with B. bronchiseptica at the age of 4 days (D0) and P. multocida at the age of 8 days (D4). Complete regeneration of the nasal turbinates was observed although severe turbinate atrophy (nasal lesion score 15) was seen from Day 18 to Day 32.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3818441&req=5

Figure 3: Sequential computed tomography scans of pig No. 4 in Experiment 2. Pig No. 4 was infected with B. bronchiseptica at the age of 4 days (D0) and P. multocida at the age of 8 days (D4). Complete regeneration of the nasal turbinates was observed although severe turbinate atrophy (nasal lesion score 15) was seen from Day 18 to Day 32.
Mentions: In the B. bronchiseptica - P. multocida infected group, 12 out of the 14 piglets had 12 or higher NLS by the time of D25 indicating rapidly developing and severe turbinate atrophy in the whole group. Interestingly, most of the pigs showed unexpected signs of reparation noticed from D60 and at the time of the termination of the study (D128) 7 out of the 14 pigs had a score of ≤3. Figure 3 demonstrates an example of such a complete regeneration of turbinate atrophy with a score of 15 on D25 and 32. Figure 4 illustrates the only case when the severe TA and NSD lasted until the termination of the study.

Bottom Line: Atrophic rhinitis is a widely prevalent infectious disease of swine caused by Bordetella bronchiseptica and Pasteurella multocida.The course of the disease is considered to be different depending on the principal aetiological agents distinguishing B. bronchiseptica induced non-progressive and toxigenic P. multocida produced progressive forms.Computed tomography has further been verified to be a useful tool to examine the pathological events of atrophic rhinitis in a longitudinal manner.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary. magyar.tibor@agrar.mta.hu.

ABSTRACT

Background: Atrophic rhinitis is a widely prevalent infectious disease of swine caused by Bordetella bronchiseptica and Pasteurella multocida. The course of the disease is considered to be different depending on the principal aetiological agents distinguishing B. bronchiseptica induced non-progressive and toxigenic P. multocida produced progressive forms. In order to compare the pathological events of the two forms of the disease, the development of nasal lesions has longitudinally been studied in pigs infected by either B. bronchiseptica alone or B. bronchiseptica and toxigenic P. multocida together using computed tomography to visualise the nasal structures.

Results: B. bronchiseptica infection alone caused moderately severe nasal turbinate atrophy and these lesions completely regenerated by the time of slaughter. Unexpectedly, complete regeneration of the bony structures of the nasal cavity was also observed in pigs infected by B. bronchiseptica and toxigenic P. multocida together in spite of seeing severe turbinate atrophy in most of the infected animals around the age of six weeks.

Conclusions: B. bronchiseptica mono-infection has been confirmed to cause only mild to moderate and transient lesions, at least in high health status pigs. Even severe turbinate atrophy induced by B. bronchiseptica and toxigenic P. multocida combined infection is able to be reorganised to their normal anatomical structure. Computed tomography has further been verified to be a useful tool to examine the pathological events of atrophic rhinitis in a longitudinal manner.

Show MeSH
Related in: MedlinePlus