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Relating inter-individual differences in verbal creative thinking to cerebral structures: an optimal voxel-based morphometry study.

Zhu F, Zhang Q, Qiu J - PLoS ONE (2013)

Bottom Line: Verbal creativity was found to be significantly positively correlated with regional GMV in the left inferior frontal gyrus (IFG), which is believed to be responsible for language production and comprehension, new semantic representation, and memory retrieval, and in the right IFG, which may involve inhibitory control and attention switching.A relationship between verbal creativity and regional WMV in the left and right IFG was also observed.Overall, a highly verbal creative individual with superior verbal skills may demonstrate a greater computational efficiency in the brain areas involved in high-level cognitive processes including language production, semantic representation and cognitive control.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China ; School of Psychology, Southwest University, Chongqing, China.

ABSTRACT
Creativity can be defined the capacity of an individual to produce something original and useful. An important measurable component of creativity is divergent thinking. Despite existing studies on creativity-related cerebral structural basis, no study has used a large sample to investigate the relationship between individual verbal creativity and regional gray matter volumes (GMVs) and white matter volumes (WMVs). In the present work, optimal voxel-based morphometry (VBM) was employed to identify the structure that correlates verbal creativity (measured by the verbal form of Torrance Tests of Creative Thinking) across the brain in young healthy subjects. Verbal creativity was found to be significantly positively correlated with regional GMV in the left inferior frontal gyrus (IFG), which is believed to be responsible for language production and comprehension, new semantic representation, and memory retrieval, and in the right IFG, which may involve inhibitory control and attention switching. A relationship between verbal creativity and regional WMV in the left and right IFG was also observed. Overall, a highly verbal creative individual with superior verbal skills may demonstrate a greater computational efficiency in the brain areas involved in high-level cognitive processes including language production, semantic representation and cognitive control.

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The relationship between regional WMV and verbal creativity.(A) Statistical parametric mapping for the covariation between subjects’ verbal TTCT total score and regional WMV, the left IFG is significantly positive associated with verbal TTCT total sore. The significant cluster is p <0.05 nonstationary corrected with an underlying uncorrelated voxel level at p<0.0001. Structural maps shown at sagittal, coronal and axial sections are overlaid on the T1-weighted images. The significant cluster is shown at t > 3.8 for visualization purpose. (B) A scatterplot between verbal TTCT total score and relative WMV of the left IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only. (C) The right IFG in which variability in regional WMV exhibited significant positive correlation with verbal TTCT total score is superimposed on a standard T1-weighted template brain in MNI stereotactic space. (D) A scatterplot between verbal TTCT total score and relative WMV of the right IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only.
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pone-0079272-g002: The relationship between regional WMV and verbal creativity.(A) Statistical parametric mapping for the covariation between subjects’ verbal TTCT total score and regional WMV, the left IFG is significantly positive associated with verbal TTCT total sore. The significant cluster is p <0.05 nonstationary corrected with an underlying uncorrelated voxel level at p<0.0001. Structural maps shown at sagittal, coronal and axial sections are overlaid on the T1-weighted images. The significant cluster is shown at t > 3.8 for visualization purpose. (B) A scatterplot between verbal TTCT total score and relative WMV of the left IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only. (C) The right IFG in which variability in regional WMV exhibited significant positive correlation with verbal TTCT total score is superimposed on a standard T1-weighted template brain in MNI stereotactic space. (D) A scatterplot between verbal TTCT total score and relative WMV of the right IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only.

Mentions: Table 3 shows the correlation of WMVs with verbal TTCT. The regional WMVs of left IFG (x = -48, y = 34, z = 3; see also Figure 2A) and right IFG (x = 49, y = 6, z = 21; see also Figure 2C) were found to be significantly positively correlated with the total score of verbal TTCT. No negative correlation was found between regional WMV and the total score of verbal TTCT after multiple comparisons. All voxels survived at cluster-level non-stationary correction for multiple comparisons (p < 0.05). Figure 2 shows the bivariate correlations between relative WMVs in the left/right IFG and the verbal TTCT score. Relative WMVs were obtained using the same approach as that used for relative GMVs.


Relating inter-individual differences in verbal creative thinking to cerebral structures: an optimal voxel-based morphometry study.

Zhu F, Zhang Q, Qiu J - PLoS ONE (2013)

The relationship between regional WMV and verbal creativity.(A) Statistical parametric mapping for the covariation between subjects’ verbal TTCT total score and regional WMV, the left IFG is significantly positive associated with verbal TTCT total sore. The significant cluster is p <0.05 nonstationary corrected with an underlying uncorrelated voxel level at p<0.0001. Structural maps shown at sagittal, coronal and axial sections are overlaid on the T1-weighted images. The significant cluster is shown at t > 3.8 for visualization purpose. (B) A scatterplot between verbal TTCT total score and relative WMV of the left IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only. (C) The right IFG in which variability in regional WMV exhibited significant positive correlation with verbal TTCT total score is superimposed on a standard T1-weighted template brain in MNI stereotactic space. (D) A scatterplot between verbal TTCT total score and relative WMV of the right IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3818430&req=5

pone-0079272-g002: The relationship between regional WMV and verbal creativity.(A) Statistical parametric mapping for the covariation between subjects’ verbal TTCT total score and regional WMV, the left IFG is significantly positive associated with verbal TTCT total sore. The significant cluster is p <0.05 nonstationary corrected with an underlying uncorrelated voxel level at p<0.0001. Structural maps shown at sagittal, coronal and axial sections are overlaid on the T1-weighted images. The significant cluster is shown at t > 3.8 for visualization purpose. (B) A scatterplot between verbal TTCT total score and relative WMV of the left IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only. (C) The right IFG in which variability in regional WMV exhibited significant positive correlation with verbal TTCT total score is superimposed on a standard T1-weighted template brain in MNI stereotactic space. (D) A scatterplot between verbal TTCT total score and relative WMV of the right IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only.
Mentions: Table 3 shows the correlation of WMVs with verbal TTCT. The regional WMVs of left IFG (x = -48, y = 34, z = 3; see also Figure 2A) and right IFG (x = 49, y = 6, z = 21; see also Figure 2C) were found to be significantly positively correlated with the total score of verbal TTCT. No negative correlation was found between regional WMV and the total score of verbal TTCT after multiple comparisons. All voxels survived at cluster-level non-stationary correction for multiple comparisons (p < 0.05). Figure 2 shows the bivariate correlations between relative WMVs in the left/right IFG and the verbal TTCT score. Relative WMVs were obtained using the same approach as that used for relative GMVs.

Bottom Line: Verbal creativity was found to be significantly positively correlated with regional GMV in the left inferior frontal gyrus (IFG), which is believed to be responsible for language production and comprehension, new semantic representation, and memory retrieval, and in the right IFG, which may involve inhibitory control and attention switching.A relationship between verbal creativity and regional WMV in the left and right IFG was also observed.Overall, a highly verbal creative individual with superior verbal skills may demonstrate a greater computational efficiency in the brain areas involved in high-level cognitive processes including language production, semantic representation and cognitive control.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China ; School of Psychology, Southwest University, Chongqing, China.

ABSTRACT
Creativity can be defined the capacity of an individual to produce something original and useful. An important measurable component of creativity is divergent thinking. Despite existing studies on creativity-related cerebral structural basis, no study has used a large sample to investigate the relationship between individual verbal creativity and regional gray matter volumes (GMVs) and white matter volumes (WMVs). In the present work, optimal voxel-based morphometry (VBM) was employed to identify the structure that correlates verbal creativity (measured by the verbal form of Torrance Tests of Creative Thinking) across the brain in young healthy subjects. Verbal creativity was found to be significantly positively correlated with regional GMV in the left inferior frontal gyrus (IFG), which is believed to be responsible for language production and comprehension, new semantic representation, and memory retrieval, and in the right IFG, which may involve inhibitory control and attention switching. A relationship between verbal creativity and regional WMV in the left and right IFG was also observed. Overall, a highly verbal creative individual with superior verbal skills may demonstrate a greater computational efficiency in the brain areas involved in high-level cognitive processes including language production, semantic representation and cognitive control.

Show MeSH
Related in: MedlinePlus