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Relating inter-individual differences in verbal creative thinking to cerebral structures: an optimal voxel-based morphometry study.

Zhu F, Zhang Q, Qiu J - PLoS ONE (2013)

Bottom Line: Verbal creativity was found to be significantly positively correlated with regional GMV in the left inferior frontal gyrus (IFG), which is believed to be responsible for language production and comprehension, new semantic representation, and memory retrieval, and in the right IFG, which may involve inhibitory control and attention switching.A relationship between verbal creativity and regional WMV in the left and right IFG was also observed.Overall, a highly verbal creative individual with superior verbal skills may demonstrate a greater computational efficiency in the brain areas involved in high-level cognitive processes including language production, semantic representation and cognitive control.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China ; School of Psychology, Southwest University, Chongqing, China.

ABSTRACT
Creativity can be defined the capacity of an individual to produce something original and useful. An important measurable component of creativity is divergent thinking. Despite existing studies on creativity-related cerebral structural basis, no study has used a large sample to investigate the relationship between individual verbal creativity and regional gray matter volumes (GMVs) and white matter volumes (WMVs). In the present work, optimal voxel-based morphometry (VBM) was employed to identify the structure that correlates verbal creativity (measured by the verbal form of Torrance Tests of Creative Thinking) across the brain in young healthy subjects. Verbal creativity was found to be significantly positively correlated with regional GMV in the left inferior frontal gyrus (IFG), which is believed to be responsible for language production and comprehension, new semantic representation, and memory retrieval, and in the right IFG, which may involve inhibitory control and attention switching. A relationship between verbal creativity and regional WMV in the left and right IFG was also observed. Overall, a highly verbal creative individual with superior verbal skills may demonstrate a greater computational efficiency in the brain areas involved in high-level cognitive processes including language production, semantic representation and cognitive control.

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The relationship between regional GMV and verbal creativity.(A) Statistical parametric mapping for the covariation between subjects’ verbal TTCT total score and regional GMV, the left IFG (BA45) is significantly positive associated with verbal TTCT total sore. The significant cluster is p < 0.05 nonstationary corrected with an underlying uncorrelated voxel level at p<0.0001. Structural maps shown at sagittal, coronal and axial sections are overlaid on the T1-weighted images. The significant cluster is shown at t > 3.8 for visualization purpose. (B) A scatterplot between verbal TTCT total score and relative GMV of the left IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only. (C) The right IFG in which variability in regional GMV exhibited significant positive correlation with verbal TTCT total score is superimposed on a standard T1-weighted template brain in MNI stereotactic space. (D) A scatterplot between verbal TTCT total score and relative GMV of right IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only.
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pone-0079272-g001: The relationship between regional GMV and verbal creativity.(A) Statistical parametric mapping for the covariation between subjects’ verbal TTCT total score and regional GMV, the left IFG (BA45) is significantly positive associated with verbal TTCT total sore. The significant cluster is p < 0.05 nonstationary corrected with an underlying uncorrelated voxel level at p<0.0001. Structural maps shown at sagittal, coronal and axial sections are overlaid on the T1-weighted images. The significant cluster is shown at t > 3.8 for visualization purpose. (B) A scatterplot between verbal TTCT total score and relative GMV of the left IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only. (C) The right IFG in which variability in regional GMV exhibited significant positive correlation with verbal TTCT total score is superimposed on a standard T1-weighted template brain in MNI stereotactic space. (D) A scatterplot between verbal TTCT total score and relative GMV of right IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only.

Mentions: After control for age, gender, general intelligence, and total gray matter volume in the multiple regression analysis, the correlation of GMVs with verbal creative thinking measured by verbal TTCT was determined (Table 2). As shown in Table 2, significantly positive correlation was found between the verbal TTCT score and the left IFG, pars triangularis (BA45: x = -50, y = 31, z = 15; see also Figure 1A), and the right IFG (x =60, y = 10, z = 17; see also Figure 1C). All voxels survived at cluster-level non-stationary correction for multiple comparisons (p < 0.05). The average local GMVs (left IFG/BA 45, right IFG) were then obtained using the “Extract ROIs signal” utilities implemented in REST [47]. To control for individual differences in whole brain size, the average relative GMVs obtained by dividing local GMVs by total gray matter volume was calculated. These average relative GMVs were then used as the dependent variables for all bivariate correlations (Figures 1B and 1D).


Relating inter-individual differences in verbal creative thinking to cerebral structures: an optimal voxel-based morphometry study.

Zhu F, Zhang Q, Qiu J - PLoS ONE (2013)

The relationship between regional GMV and verbal creativity.(A) Statistical parametric mapping for the covariation between subjects’ verbal TTCT total score and regional GMV, the left IFG (BA45) is significantly positive associated with verbal TTCT total sore. The significant cluster is p < 0.05 nonstationary corrected with an underlying uncorrelated voxel level at p<0.0001. Structural maps shown at sagittal, coronal and axial sections are overlaid on the T1-weighted images. The significant cluster is shown at t > 3.8 for visualization purpose. (B) A scatterplot between verbal TTCT total score and relative GMV of the left IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only. (C) The right IFG in which variability in regional GMV exhibited significant positive correlation with verbal TTCT total score is superimposed on a standard T1-weighted template brain in MNI stereotactic space. (D) A scatterplot between verbal TTCT total score and relative GMV of right IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3818430&req=5

pone-0079272-g001: The relationship between regional GMV and verbal creativity.(A) Statistical parametric mapping for the covariation between subjects’ verbal TTCT total score and regional GMV, the left IFG (BA45) is significantly positive associated with verbal TTCT total sore. The significant cluster is p < 0.05 nonstationary corrected with an underlying uncorrelated voxel level at p<0.0001. Structural maps shown at sagittal, coronal and axial sections are overlaid on the T1-weighted images. The significant cluster is shown at t > 3.8 for visualization purpose. (B) A scatterplot between verbal TTCT total score and relative GMV of the left IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only. (C) The right IFG in which variability in regional GMV exhibited significant positive correlation with verbal TTCT total score is superimposed on a standard T1-weighted template brain in MNI stereotactic space. (D) A scatterplot between verbal TTCT total score and relative GMV of right IFG adjusted for age, gender, and general intelligence is shown for illustration purpose only.
Mentions: After control for age, gender, general intelligence, and total gray matter volume in the multiple regression analysis, the correlation of GMVs with verbal creative thinking measured by verbal TTCT was determined (Table 2). As shown in Table 2, significantly positive correlation was found between the verbal TTCT score and the left IFG, pars triangularis (BA45: x = -50, y = 31, z = 15; see also Figure 1A), and the right IFG (x =60, y = 10, z = 17; see also Figure 1C). All voxels survived at cluster-level non-stationary correction for multiple comparisons (p < 0.05). The average local GMVs (left IFG/BA 45, right IFG) were then obtained using the “Extract ROIs signal” utilities implemented in REST [47]. To control for individual differences in whole brain size, the average relative GMVs obtained by dividing local GMVs by total gray matter volume was calculated. These average relative GMVs were then used as the dependent variables for all bivariate correlations (Figures 1B and 1D).

Bottom Line: Verbal creativity was found to be significantly positively correlated with regional GMV in the left inferior frontal gyrus (IFG), which is believed to be responsible for language production and comprehension, new semantic representation, and memory retrieval, and in the right IFG, which may involve inhibitory control and attention switching.A relationship between verbal creativity and regional WMV in the left and right IFG was also observed.Overall, a highly verbal creative individual with superior verbal skills may demonstrate a greater computational efficiency in the brain areas involved in high-level cognitive processes including language production, semantic representation and cognitive control.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China ; School of Psychology, Southwest University, Chongqing, China.

ABSTRACT
Creativity can be defined the capacity of an individual to produce something original and useful. An important measurable component of creativity is divergent thinking. Despite existing studies on creativity-related cerebral structural basis, no study has used a large sample to investigate the relationship between individual verbal creativity and regional gray matter volumes (GMVs) and white matter volumes (WMVs). In the present work, optimal voxel-based morphometry (VBM) was employed to identify the structure that correlates verbal creativity (measured by the verbal form of Torrance Tests of Creative Thinking) across the brain in young healthy subjects. Verbal creativity was found to be significantly positively correlated with regional GMV in the left inferior frontal gyrus (IFG), which is believed to be responsible for language production and comprehension, new semantic representation, and memory retrieval, and in the right IFG, which may involve inhibitory control and attention switching. A relationship between verbal creativity and regional WMV in the left and right IFG was also observed. Overall, a highly verbal creative individual with superior verbal skills may demonstrate a greater computational efficiency in the brain areas involved in high-level cognitive processes including language production, semantic representation and cognitive control.

Show MeSH
Related in: MedlinePlus