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Effect of hydrophobic acrylic versus hydrophilic acrylic intraocular lens on posterior capsule opacification: meta-analysis.

Li Y, Wang J, Chen Z, Tang X - PLoS ONE (2013)

Bottom Line: The PCO scores and YAG capsulotomy rate, as indicator of PCO, were measured and discussed in a meta-analysis.Standardized mean differences (SMD), relative risk ratio (RR), and the pooled estimates were computed according to a random effect model or fixed effect model.More RCTs with standard methods for longer follow-up are needed to validate the association.

View Article: PubMed Central - PubMed

Affiliation: Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital, Tianjin, China.

ABSTRACT

Purpose: This meta-analysis aims to evaluate the differences in performance of posterior capsular opacification (PCO) between hydrophobic acrylic intraocular lens (IOLs) and hydrophilic acrylic IOLs.

Setting: Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China.

Design: Systematic review of randomized controlled trials (RCTs) or meta-analysis.

Methods: An electronic literature search was performed using the PubMed, EMBASE and Cochrane Library database before May in 2013 to identify prospective RCTs comparing hydrophobic acrylic IOLs and hydrophilic acrylic IOLs in patients after phacoemulsification with IOL implantation with a follow-up time of at least 1 year. Pertinent studies were selected by meeting predefined criteria and reviewed systematically by meta-analysis. The PCO scores and YAG capsulotomy rate, as indicator of PCO, were measured and discussed in a meta-analysis. Standardized mean differences (SMD), relative risk ratio (RR), and the pooled estimates were computed according to a random effect model or fixed effect model.

Results: Nine prospective RCTs involving 861 eyes were included in the current meta-analysis. The hydrophobic acrylic IOLs were favored and the pooled SMD of PCO severity was 1.72 (95% confidence interval (CI), 0.20 to 1.23, P = 0.0002) and 1.79 (95% CI, 0.95 to 2.64, P<0.0001) with 1-year follow-up and 2-year follow-up respectively. The pooled RR of Nd:YAG laser capsulotomy rates at postoperative 2-year follow-up was 6.96 (95% CI, 3.69 to 13.11, P<0.00001) comparing hydrophilic acrylic IOLs with hydrophobic acrylic IOLs.

Conclusions: Compared with hydrophilic acrylic IOLs, the hydrophobic acrylic IOLs showed superior reduction in rates of PCO and laser capsulotomy in 2-year follow-up. More RCTs with standard methods for longer follow-up are needed to validate the association.

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Related in: MedlinePlus

Forest plots describing effects of hydrophobic acrylic versus hydrophilic acrylic IOLs on development of posterior capsule opacification in 1-year follow-up.(Chi2  =  chi square statistic, CI  =  confidence interval, df  =  degrees of freedom, I2  =  I-square heterogeneity statistic, IV  =  inverse variance, SMD  =  standard mean difference, Z  =  Z-statistic).
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pone-0077864-g002: Forest plots describing effects of hydrophobic acrylic versus hydrophilic acrylic IOLs on development of posterior capsule opacification in 1-year follow-up.(Chi2  =  chi square statistic, CI  =  confidence interval, df  =  degrees of freedom, I2  =  I-square heterogeneity statistic, IV  =  inverse variance, SMD  =  standard mean difference, Z  =  Z-statistic).

Mentions: Based on 7 studies (620 total eyes) that evaluated PCO after a 1-year follow-up period[2], [8], [12], [14]–[16], [18], hydrophobic acrylic IOLs were associated with significantly lower PCO scores than hydrophilic acrylic IOLs; the SMD was 1.72 (95% CI, 0.82 to 2.63, P = 0.0002). The data showed that they had heterogeneity of effect size (P<0.00001, I2 = 96%), so the random effect model was used for meta-analysis. The results are shown in Figure 2.


Effect of hydrophobic acrylic versus hydrophilic acrylic intraocular lens on posterior capsule opacification: meta-analysis.

Li Y, Wang J, Chen Z, Tang X - PLoS ONE (2013)

Forest plots describing effects of hydrophobic acrylic versus hydrophilic acrylic IOLs on development of posterior capsule opacification in 1-year follow-up.(Chi2  =  chi square statistic, CI  =  confidence interval, df  =  degrees of freedom, I2  =  I-square heterogeneity statistic, IV  =  inverse variance, SMD  =  standard mean difference, Z  =  Z-statistic).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3818402&req=5

pone-0077864-g002: Forest plots describing effects of hydrophobic acrylic versus hydrophilic acrylic IOLs on development of posterior capsule opacification in 1-year follow-up.(Chi2  =  chi square statistic, CI  =  confidence interval, df  =  degrees of freedom, I2  =  I-square heterogeneity statistic, IV  =  inverse variance, SMD  =  standard mean difference, Z  =  Z-statistic).
Mentions: Based on 7 studies (620 total eyes) that evaluated PCO after a 1-year follow-up period[2], [8], [12], [14]–[16], [18], hydrophobic acrylic IOLs were associated with significantly lower PCO scores than hydrophilic acrylic IOLs; the SMD was 1.72 (95% CI, 0.82 to 2.63, P = 0.0002). The data showed that they had heterogeneity of effect size (P<0.00001, I2 = 96%), so the random effect model was used for meta-analysis. The results are shown in Figure 2.

Bottom Line: The PCO scores and YAG capsulotomy rate, as indicator of PCO, were measured and discussed in a meta-analysis.Standardized mean differences (SMD), relative risk ratio (RR), and the pooled estimates were computed according to a random effect model or fixed effect model.More RCTs with standard methods for longer follow-up are needed to validate the association.

View Article: PubMed Central - PubMed

Affiliation: Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital, Tianjin, China.

ABSTRACT

Purpose: This meta-analysis aims to evaluate the differences in performance of posterior capsular opacification (PCO) between hydrophobic acrylic intraocular lens (IOLs) and hydrophilic acrylic IOLs.

Setting: Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China.

Design: Systematic review of randomized controlled trials (RCTs) or meta-analysis.

Methods: An electronic literature search was performed using the PubMed, EMBASE and Cochrane Library database before May in 2013 to identify prospective RCTs comparing hydrophobic acrylic IOLs and hydrophilic acrylic IOLs in patients after phacoemulsification with IOL implantation with a follow-up time of at least 1 year. Pertinent studies were selected by meeting predefined criteria and reviewed systematically by meta-analysis. The PCO scores and YAG capsulotomy rate, as indicator of PCO, were measured and discussed in a meta-analysis. Standardized mean differences (SMD), relative risk ratio (RR), and the pooled estimates were computed according to a random effect model or fixed effect model.

Results: Nine prospective RCTs involving 861 eyes were included in the current meta-analysis. The hydrophobic acrylic IOLs were favored and the pooled SMD of PCO severity was 1.72 (95% confidence interval (CI), 0.20 to 1.23, P = 0.0002) and 1.79 (95% CI, 0.95 to 2.64, P<0.0001) with 1-year follow-up and 2-year follow-up respectively. The pooled RR of Nd:YAG laser capsulotomy rates at postoperative 2-year follow-up was 6.96 (95% CI, 3.69 to 13.11, P<0.00001) comparing hydrophilic acrylic IOLs with hydrophobic acrylic IOLs.

Conclusions: Compared with hydrophilic acrylic IOLs, the hydrophobic acrylic IOLs showed superior reduction in rates of PCO and laser capsulotomy in 2-year follow-up. More RCTs with standard methods for longer follow-up are needed to validate the association.

Show MeSH
Related in: MedlinePlus