Limits...
Effect of hydrophobic acrylic versus hydrophilic acrylic intraocular lens on posterior capsule opacification: meta-analysis.

Li Y, Wang J, Chen Z, Tang X - PLoS ONE (2013)

Bottom Line: The PCO scores and YAG capsulotomy rate, as indicator of PCO, were measured and discussed in a meta-analysis.Standardized mean differences (SMD), relative risk ratio (RR), and the pooled estimates were computed according to a random effect model or fixed effect model.More RCTs with standard methods for longer follow-up are needed to validate the association.

View Article: PubMed Central - PubMed

Affiliation: Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital, Tianjin, China.

ABSTRACT

Purpose: This meta-analysis aims to evaluate the differences in performance of posterior capsular opacification (PCO) between hydrophobic acrylic intraocular lens (IOLs) and hydrophilic acrylic IOLs.

Setting: Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China.

Design: Systematic review of randomized controlled trials (RCTs) or meta-analysis.

Methods: An electronic literature search was performed using the PubMed, EMBASE and Cochrane Library database before May in 2013 to identify prospective RCTs comparing hydrophobic acrylic IOLs and hydrophilic acrylic IOLs in patients after phacoemulsification with IOL implantation with a follow-up time of at least 1 year. Pertinent studies were selected by meeting predefined criteria and reviewed systematically by meta-analysis. The PCO scores and YAG capsulotomy rate, as indicator of PCO, were measured and discussed in a meta-analysis. Standardized mean differences (SMD), relative risk ratio (RR), and the pooled estimates were computed according to a random effect model or fixed effect model.

Results: Nine prospective RCTs involving 861 eyes were included in the current meta-analysis. The hydrophobic acrylic IOLs were favored and the pooled SMD of PCO severity was 1.72 (95% confidence interval (CI), 0.20 to 1.23, P = 0.0002) and 1.79 (95% CI, 0.95 to 2.64, P<0.0001) with 1-year follow-up and 2-year follow-up respectively. The pooled RR of Nd:YAG laser capsulotomy rates at postoperative 2-year follow-up was 6.96 (95% CI, 3.69 to 13.11, P<0.00001) comparing hydrophilic acrylic IOLs with hydrophobic acrylic IOLs.

Conclusions: Compared with hydrophilic acrylic IOLs, the hydrophobic acrylic IOLs showed superior reduction in rates of PCO and laser capsulotomy in 2-year follow-up. More RCTs with standard methods for longer follow-up are needed to validate the association.

Show MeSH

Related in: MedlinePlus

Flow chart of literature search and study selection.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3818402&req=5

pone-0077864-g001: Flow chart of literature search and study selection.

Mentions: This review was conducted following the QUOROM guideline standards [10]. Reports of randomized controlled trials (RCTs) comparing hydrophobic acrylic and hydrophilic acrylic IOLs in patients after phacoemulsification with IOL implantation were identified through a computerized literature search. The systematic search was conducted in the PubMed, EMBASE, and Cochrane Controlled Trials Register database up to the end of May 2013 by using the search terms “posterior capsular opacification” “intraocular lens” “hydrophilic” “hydrophobic” and limiting the search to reports of randomized controlled trials. The abstract of all potentially relevant articles were screened to determine their relevance followed by evaluation of candidate full articles. In addition, literature reference proceedings were scanned manually to obtain extra eligible trials until no more relevant trials were found in databases. For data collected from duplicate patient groups, only the most recent studies were included in each part of meta-analysis. The process of trials selection is shown in Figure 1. Two independent investigators performed the literature search (YL, JXW).


Effect of hydrophobic acrylic versus hydrophilic acrylic intraocular lens on posterior capsule opacification: meta-analysis.

Li Y, Wang J, Chen Z, Tang X - PLoS ONE (2013)

Flow chart of literature search and study selection.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3818402&req=5

pone-0077864-g001: Flow chart of literature search and study selection.
Mentions: This review was conducted following the QUOROM guideline standards [10]. Reports of randomized controlled trials (RCTs) comparing hydrophobic acrylic and hydrophilic acrylic IOLs in patients after phacoemulsification with IOL implantation were identified through a computerized literature search. The systematic search was conducted in the PubMed, EMBASE, and Cochrane Controlled Trials Register database up to the end of May 2013 by using the search terms “posterior capsular opacification” “intraocular lens” “hydrophilic” “hydrophobic” and limiting the search to reports of randomized controlled trials. The abstract of all potentially relevant articles were screened to determine their relevance followed by evaluation of candidate full articles. In addition, literature reference proceedings were scanned manually to obtain extra eligible trials until no more relevant trials were found in databases. For data collected from duplicate patient groups, only the most recent studies were included in each part of meta-analysis. The process of trials selection is shown in Figure 1. Two independent investigators performed the literature search (YL, JXW).

Bottom Line: The PCO scores and YAG capsulotomy rate, as indicator of PCO, were measured and discussed in a meta-analysis.Standardized mean differences (SMD), relative risk ratio (RR), and the pooled estimates were computed according to a random effect model or fixed effect model.More RCTs with standard methods for longer follow-up are needed to validate the association.

View Article: PubMed Central - PubMed

Affiliation: Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital, Tianjin, China.

ABSTRACT

Purpose: This meta-analysis aims to evaluate the differences in performance of posterior capsular opacification (PCO) between hydrophobic acrylic intraocular lens (IOLs) and hydrophilic acrylic IOLs.

Setting: Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China.

Design: Systematic review of randomized controlled trials (RCTs) or meta-analysis.

Methods: An electronic literature search was performed using the PubMed, EMBASE and Cochrane Library database before May in 2013 to identify prospective RCTs comparing hydrophobic acrylic IOLs and hydrophilic acrylic IOLs in patients after phacoemulsification with IOL implantation with a follow-up time of at least 1 year. Pertinent studies were selected by meeting predefined criteria and reviewed systematically by meta-analysis. The PCO scores and YAG capsulotomy rate, as indicator of PCO, were measured and discussed in a meta-analysis. Standardized mean differences (SMD), relative risk ratio (RR), and the pooled estimates were computed according to a random effect model or fixed effect model.

Results: Nine prospective RCTs involving 861 eyes were included in the current meta-analysis. The hydrophobic acrylic IOLs were favored and the pooled SMD of PCO severity was 1.72 (95% confidence interval (CI), 0.20 to 1.23, P = 0.0002) and 1.79 (95% CI, 0.95 to 2.64, P<0.0001) with 1-year follow-up and 2-year follow-up respectively. The pooled RR of Nd:YAG laser capsulotomy rates at postoperative 2-year follow-up was 6.96 (95% CI, 3.69 to 13.11, P<0.00001) comparing hydrophilic acrylic IOLs with hydrophobic acrylic IOLs.

Conclusions: Compared with hydrophilic acrylic IOLs, the hydrophobic acrylic IOLs showed superior reduction in rates of PCO and laser capsulotomy in 2-year follow-up. More RCTs with standard methods for longer follow-up are needed to validate the association.

Show MeSH
Related in: MedlinePlus