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Dmbt1 does not affect a Western style diet-induced liver damage in mice.

Reichold A, Brenner SA, Förster-Fromme K, Bergheim I, Mollenhauer J, Bischoff SC - J Clin Biochem Nutr (2013)

Bottom Line: In addition Deleted in malignant brain tumors 1 seems to play a role in regard to the maintenance of the intestinal homeostasis and the regulation of food intake.The presence/absence of functional Deleted in malignant brain tumors 1 had no effect on parameters like food intake, weight gain, fasting glucose, and liver damage.These results suggest that Deleted in malignant brain tumors 1 plays a minor part on the development of a diet-induced liver damage in mice.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutritional Medicine, University of Hohenheim (180 a), Fruwirthstrasse 12, 70599 Stuttgart, Germany.

ABSTRACT
In the last three decades the prevalence of non-alcoholic fatty liver disease has markedly increased. Results from epidemiologic studies indicate that not only a general overnutrition but rather a diet rich in sugar, fat and cholesterol (= Western style diet) maybe a risk factor for the development of non-alcoholic fatty liver disease. Concerning liver diseases, it is known that Deleted in malignant brain tumors 1 is amongst others related to liver injury and repair. In addition Deleted in malignant brain tumors 1 seems to play a role in regard to the maintenance of the intestinal homeostasis and the regulation of food intake. Starting from this background the aim of the present study was to investigate if Dmbt1 plays a role in Western style diet-induced non-alcoholic steatohepatitis in mice. Dmbt1 (+/+) and Dmbt1 (-/-) mice were fed a Western style diet or control diet ad libitum for 12 weeks. Both Western style diet fed groups gained significant more weight than the controls and developed a mild non-alcoholic steatohepatitis. The presence/absence of functional Deleted in malignant brain tumors 1 had no effect on parameters like food intake, weight gain, fasting glucose, and liver damage. These results suggest that Deleted in malignant brain tumors 1 plays a minor part on the development of a diet-induced liver damage in mice.

No MeSH data available.


Related in: MedlinePlus

Effect of a Dmbt1 deletion on ALT and AST levels after feeding a Western style diet in Dmbt1–/– and Dmbt1+/+ mice. Activity levels of (A) alanine-aminotransferase (ALT) and (B) aspartate-aminotransferase (AST) in U/L determined in the portal plasma.
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Related In: Results  -  Collection


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Figure 2: Effect of a Dmbt1 deletion on ALT and AST levels after feeding a Western style diet in Dmbt1–/– and Dmbt1+/+ mice. Activity levels of (A) alanine-aminotransferase (ALT) and (B) aspartate-aminotransferase (AST) in U/L determined in the portal plasma.

Mentions: In line with these findings, levels of transaminases were also markedly higher in Dmbt1−/− and Dmbt1+/+ mice exposed to the Western style diet in comparison to the respective controls; a similar effect was not found in mice being fed a control diet (Fig. 2 A and B). However, as values varied considerable within groups, differences did not reach the level of significance.


Dmbt1 does not affect a Western style diet-induced liver damage in mice.

Reichold A, Brenner SA, Förster-Fromme K, Bergheim I, Mollenhauer J, Bischoff SC - J Clin Biochem Nutr (2013)

Effect of a Dmbt1 deletion on ALT and AST levels after feeding a Western style diet in Dmbt1–/– and Dmbt1+/+ mice. Activity levels of (A) alanine-aminotransferase (ALT) and (B) aspartate-aminotransferase (AST) in U/L determined in the portal plasma.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3818268&req=5

Figure 2: Effect of a Dmbt1 deletion on ALT and AST levels after feeding a Western style diet in Dmbt1–/– and Dmbt1+/+ mice. Activity levels of (A) alanine-aminotransferase (ALT) and (B) aspartate-aminotransferase (AST) in U/L determined in the portal plasma.
Mentions: In line with these findings, levels of transaminases were also markedly higher in Dmbt1−/− and Dmbt1+/+ mice exposed to the Western style diet in comparison to the respective controls; a similar effect was not found in mice being fed a control diet (Fig. 2 A and B). However, as values varied considerable within groups, differences did not reach the level of significance.

Bottom Line: In addition Deleted in malignant brain tumors 1 seems to play a role in regard to the maintenance of the intestinal homeostasis and the regulation of food intake.The presence/absence of functional Deleted in malignant brain tumors 1 had no effect on parameters like food intake, weight gain, fasting glucose, and liver damage.These results suggest that Deleted in malignant brain tumors 1 plays a minor part on the development of a diet-induced liver damage in mice.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutritional Medicine, University of Hohenheim (180 a), Fruwirthstrasse 12, 70599 Stuttgart, Germany.

ABSTRACT
In the last three decades the prevalence of non-alcoholic fatty liver disease has markedly increased. Results from epidemiologic studies indicate that not only a general overnutrition but rather a diet rich in sugar, fat and cholesterol (= Western style diet) maybe a risk factor for the development of non-alcoholic fatty liver disease. Concerning liver diseases, it is known that Deleted in malignant brain tumors 1 is amongst others related to liver injury and repair. In addition Deleted in malignant brain tumors 1 seems to play a role in regard to the maintenance of the intestinal homeostasis and the regulation of food intake. Starting from this background the aim of the present study was to investigate if Dmbt1 plays a role in Western style diet-induced non-alcoholic steatohepatitis in mice. Dmbt1 (+/+) and Dmbt1 (-/-) mice were fed a Western style diet or control diet ad libitum for 12 weeks. Both Western style diet fed groups gained significant more weight than the controls and developed a mild non-alcoholic steatohepatitis. The presence/absence of functional Deleted in malignant brain tumors 1 had no effect on parameters like food intake, weight gain, fasting glucose, and liver damage. These results suggest that Deleted in malignant brain tumors 1 plays a minor part on the development of a diet-induced liver damage in mice.

No MeSH data available.


Related in: MedlinePlus