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Changes in brain tissue and behavior patterns induced by single short-term fasting in mice.

Hisatomi Y, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K - PLoS ONE (2013)

Bottom Line: However, the effects of single short-term fasting on brain tissue or behavioral activity patterns remain unclear.The brain weight did not change by a fast, and brain atrophy was not observed.However, it is interesting that the results of this study suggest that single short-term fasting has an effect on encephalic neuropoiesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Health and Nutrition Science, Faculty of Health and Social Welfare Science, Nishikyushu University, Kanzaki, Saga, Japan.

ABSTRACT
In humans, emaciation from long-term dietary deficiencies, such as anorexia, reportedly increases physical activity and brain atrophy. However, the effects of single short-term fasting on brain tissue or behavioral activity patterns remain unclear. To clarify the impact of malnutrition on brain function, we conducted a single short-term fasting study as an anorexia model using male adult mice and determined if changes occurred in migratory behavior as an expression of brain function and in brain tissue structure. Sixteen-week-old C57BL/6J male mice were divided into either the fasted group or the control group. Experiments were conducted in a fixed indoor environment. We examined the effects of fasting on the number of nerve cells, structural changes in the myelin and axon density, and brain atrophy. For behavior observation, the amount of food and water consumed, ingestion time, and the pattern of movement were measured using a time-recording system. The fasted mice showed a significant increase in physical activity and their rhythm of movement was disturbed. Since the brain was in an abnormal state after fasting, mice that were normally active during the night became active regardless of day or night and performed strenuous exercise at a high frequency. The brain weight did not change by a fast, and brain atrophy was not observed. Although no textural change was apparent by fasting, the neuronal neogenesis in the subventricular zone and hippocampus was inhibited, causing disorder of the brain function. A clear association between the suppression of encephalic neuropoiesis and overactivity was not established. However, it is interesting that the results of this study suggest that single short-term fasting has an effect on encephalic neuropoiesis.

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Related in: MedlinePlus

Macroscopic images of brain tissue.Macroscopically, upon dissection, we could not see any atrophy upon fasting and there was no change in wet weight of the brain. However, the surface of brain tissue appeared less glossy and seemed to have lost precision.
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pone-0080085-g006: Macroscopic images of brain tissue.Macroscopically, upon dissection, we could not see any atrophy upon fasting and there was no change in wet weight of the brain. However, the surface of brain tissue appeared less glossy and seemed to have lost precision.

Mentions: However, it was observed that the tissue gloss on the surface of the brain was duller and the anatomical structures of the brain were less defined in the fasted mice (Figure 6).


Changes in brain tissue and behavior patterns induced by single short-term fasting in mice.

Hisatomi Y, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K - PLoS ONE (2013)

Macroscopic images of brain tissue.Macroscopically, upon dissection, we could not see any atrophy upon fasting and there was no change in wet weight of the brain. However, the surface of brain tissue appeared less glossy and seemed to have lost precision.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3818263&req=5

pone-0080085-g006: Macroscopic images of brain tissue.Macroscopically, upon dissection, we could not see any atrophy upon fasting and there was no change in wet weight of the brain. However, the surface of brain tissue appeared less glossy and seemed to have lost precision.
Mentions: However, it was observed that the tissue gloss on the surface of the brain was duller and the anatomical structures of the brain were less defined in the fasted mice (Figure 6).

Bottom Line: However, the effects of single short-term fasting on brain tissue or behavioral activity patterns remain unclear.The brain weight did not change by a fast, and brain atrophy was not observed.However, it is interesting that the results of this study suggest that single short-term fasting has an effect on encephalic neuropoiesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Health and Nutrition Science, Faculty of Health and Social Welfare Science, Nishikyushu University, Kanzaki, Saga, Japan.

ABSTRACT
In humans, emaciation from long-term dietary deficiencies, such as anorexia, reportedly increases physical activity and brain atrophy. However, the effects of single short-term fasting on brain tissue or behavioral activity patterns remain unclear. To clarify the impact of malnutrition on brain function, we conducted a single short-term fasting study as an anorexia model using male adult mice and determined if changes occurred in migratory behavior as an expression of brain function and in brain tissue structure. Sixteen-week-old C57BL/6J male mice were divided into either the fasted group or the control group. Experiments were conducted in a fixed indoor environment. We examined the effects of fasting on the number of nerve cells, structural changes in the myelin and axon density, and brain atrophy. For behavior observation, the amount of food and water consumed, ingestion time, and the pattern of movement were measured using a time-recording system. The fasted mice showed a significant increase in physical activity and their rhythm of movement was disturbed. Since the brain was in an abnormal state after fasting, mice that were normally active during the night became active regardless of day or night and performed strenuous exercise at a high frequency. The brain weight did not change by a fast, and brain atrophy was not observed. Although no textural change was apparent by fasting, the neuronal neogenesis in the subventricular zone and hippocampus was inhibited, causing disorder of the brain function. A clear association between the suppression of encephalic neuropoiesis and overactivity was not established. However, it is interesting that the results of this study suggest that single short-term fasting has an effect on encephalic neuropoiesis.

Show MeSH
Related in: MedlinePlus