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Cognitive performance of Göttingen minipigs is affected by diet in a spatial hole-board discrimination test.

Haagensen AM, Klein AB, Ettrup A, Matthews LR, Sørensen DB - PLoS ONE (2013)

Bottom Line: We sought to contrast the effect of a high fat/cholesterol, low carbohydrate diet and a low fat, high carbohydrate/sucrose diet, relative to a standard low fat, high carbohydrate minipig diet on spatial cognition with regards to working memory and reference memory in 24 male Göttingen minipigs performing in a spatial hole-board discrimination test.The different diets did not impact levels of brain-derived neurotrophic factor in brain tissue and neither did they affect circulatory inflammation measured by concentrations of C-reactive protein and haptoglobin in serum.These findings suggest that high dietary intake of both fat and sugar may impair spatial cognition which could be relevant for mental functioning in humans.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Disease Biology, Section of Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.

ABSTRACT
Consumption of a high energy diet, containing high amounts of saturated fat and refined sugar has been associated with impairment of cognitive function in rodents and humans. We sought to contrast the effect of a high fat/cholesterol, low carbohydrate diet and a low fat, high carbohydrate/sucrose diet, relative to a standard low fat, high carbohydrate minipig diet on spatial cognition with regards to working memory and reference memory in 24 male Göttingen minipigs performing in a spatial hole-board discrimination test. We found that both working memory and reference memory were impaired by both diets relative to a standard minipig diet high in carbohydrate, low in fat and sugar. The different diets did not impact levels of brain-derived neurotrophic factor in brain tissue and neither did they affect circulatory inflammation measured by concentrations of C-reactive protein and haptoglobin in serum. However, higher levels of triglycerides were observed for minipigs fed the diets with high fat/cholesterol, low carbohydrate and low fat, high carbohydrate/sucrose compared to minipigs fed a standard minipig diet. This might explain the observed impairments in spatial cognition. These findings suggest that high dietary intake of both fat and sugar may impair spatial cognition which could be relevant for mental functioning in humans.

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Related in: MedlinePlus

Body weight (kg) of minipigs by the end of the study.Low fat, high carbohydrate (LFHC); high fat/cholesterol, low carbohydrate (HFLC); low fat, high carbohydrate/sucrose (LFHS). * p < 0.05.
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pone-0079429-g007: Body weight (kg) of minipigs by the end of the study.Low fat, high carbohydrate (LFHC); high fat/cholesterol, low carbohydrate (HFLC); low fat, high carbohydrate/sucrose (LFHS). * p < 0.05.

Mentions: Body weights (Figure 7) differed between diet groups (LFHC vs. HFLC and LFHS) by the end of the study (F2,21 = 4.603, p = 0.0220), with a high variation within LFHC minipigs and LFHS minipigs. A positive correlation between body weight and trial duration was found for trial block A (13-16): (r = 0.5502, p = 0.0080, 95% CI = 0.1543 - 0.7938) and for working memory for trial block R (1-4): (r = 0.4578, p = 0.0322, 95% CI = 0.03140 - 0.7432).


Cognitive performance of Göttingen minipigs is affected by diet in a spatial hole-board discrimination test.

Haagensen AM, Klein AB, Ettrup A, Matthews LR, Sørensen DB - PLoS ONE (2013)

Body weight (kg) of minipigs by the end of the study.Low fat, high carbohydrate (LFHC); high fat/cholesterol, low carbohydrate (HFLC); low fat, high carbohydrate/sucrose (LFHS). * p < 0.05.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3818226&req=5

pone-0079429-g007: Body weight (kg) of minipigs by the end of the study.Low fat, high carbohydrate (LFHC); high fat/cholesterol, low carbohydrate (HFLC); low fat, high carbohydrate/sucrose (LFHS). * p < 0.05.
Mentions: Body weights (Figure 7) differed between diet groups (LFHC vs. HFLC and LFHS) by the end of the study (F2,21 = 4.603, p = 0.0220), with a high variation within LFHC minipigs and LFHS minipigs. A positive correlation between body weight and trial duration was found for trial block A (13-16): (r = 0.5502, p = 0.0080, 95% CI = 0.1543 - 0.7938) and for working memory for trial block R (1-4): (r = 0.4578, p = 0.0322, 95% CI = 0.03140 - 0.7432).

Bottom Line: We sought to contrast the effect of a high fat/cholesterol, low carbohydrate diet and a low fat, high carbohydrate/sucrose diet, relative to a standard low fat, high carbohydrate minipig diet on spatial cognition with regards to working memory and reference memory in 24 male Göttingen minipigs performing in a spatial hole-board discrimination test.The different diets did not impact levels of brain-derived neurotrophic factor in brain tissue and neither did they affect circulatory inflammation measured by concentrations of C-reactive protein and haptoglobin in serum.These findings suggest that high dietary intake of both fat and sugar may impair spatial cognition which could be relevant for mental functioning in humans.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Disease Biology, Section of Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.

ABSTRACT
Consumption of a high energy diet, containing high amounts of saturated fat and refined sugar has been associated with impairment of cognitive function in rodents and humans. We sought to contrast the effect of a high fat/cholesterol, low carbohydrate diet and a low fat, high carbohydrate/sucrose diet, relative to a standard low fat, high carbohydrate minipig diet on spatial cognition with regards to working memory and reference memory in 24 male Göttingen minipigs performing in a spatial hole-board discrimination test. We found that both working memory and reference memory were impaired by both diets relative to a standard minipig diet high in carbohydrate, low in fat and sugar. The different diets did not impact levels of brain-derived neurotrophic factor in brain tissue and neither did they affect circulatory inflammation measured by concentrations of C-reactive protein and haptoglobin in serum. However, higher levels of triglycerides were observed for minipigs fed the diets with high fat/cholesterol, low carbohydrate and low fat, high carbohydrate/sucrose compared to minipigs fed a standard minipig diet. This might explain the observed impairments in spatial cognition. These findings suggest that high dietary intake of both fat and sugar may impair spatial cognition which could be relevant for mental functioning in humans.

Show MeSH
Related in: MedlinePlus