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N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder.

Moreno-Villanueva M, Morath J, Vanhooren V, Elbert T, Kolassa S, Libert C, Bürkle A, Kolassa IT - Transl Psychiatry (2013)

Bottom Line: However, the underlying biological mechanisms are still unclear.N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test).In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.

View Article: PubMed Central - PubMed

Affiliation: Molecular Toxicology Group, Department of Biology, University of Konstanz, Konstanz, Germany.

ABSTRACT
The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.

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Related in: MedlinePlus

Scatterplots in the N-glycan peak 7 from n=10 low-stress controls, n=9 trauma-exposed and n=13 PTSD subjects. Individuals with PTSD demonstrated significant lower values in the N-glycan peak 7, compared with low-stress controls. Trauma-exposed individuals were positioned between PTSD and the low-stress control group.
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fig3: Scatterplots in the N-glycan peak 7 from n=10 low-stress controls, n=9 trauma-exposed and n=13 PTSD subjects. Individuals with PTSD demonstrated significant lower values in the N-glycan peak 7, compared with low-stress controls. Trauma-exposed individuals were positioned between PTSD and the low-stress control group.

Mentions: Further, individuals with PTSD, surprisingly, presented reduced values in N-glycan peak 7 (F(2,29)=4.35; P=0.02). Individuals with PTSD differed significantly from the low-stress control group (t(11.9)=2.75; P=0.02), and trauma-exposed individuals were positioned in-between, but did not differ significantly from the PTSD or the low-stress control group (Table 2 and Figure 3).


N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder.

Moreno-Villanueva M, Morath J, Vanhooren V, Elbert T, Kolassa S, Libert C, Bürkle A, Kolassa IT - Transl Psychiatry (2013)

Scatterplots in the N-glycan peak 7 from n=10 low-stress controls, n=9 trauma-exposed and n=13 PTSD subjects. Individuals with PTSD demonstrated significant lower values in the N-glycan peak 7, compared with low-stress controls. Trauma-exposed individuals were positioned between PTSD and the low-stress control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3818009&req=5

fig3: Scatterplots in the N-glycan peak 7 from n=10 low-stress controls, n=9 trauma-exposed and n=13 PTSD subjects. Individuals with PTSD demonstrated significant lower values in the N-glycan peak 7, compared with low-stress controls. Trauma-exposed individuals were positioned between PTSD and the low-stress control group.
Mentions: Further, individuals with PTSD, surprisingly, presented reduced values in N-glycan peak 7 (F(2,29)=4.35; P=0.02). Individuals with PTSD differed significantly from the low-stress control group (t(11.9)=2.75; P=0.02), and trauma-exposed individuals were positioned in-between, but did not differ significantly from the PTSD or the low-stress control group (Table 2 and Figure 3).

Bottom Line: However, the underlying biological mechanisms are still unclear.N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test).In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.

View Article: PubMed Central - PubMed

Affiliation: Molecular Toxicology Group, Department of Biology, University of Konstanz, Konstanz, Germany.

ABSTRACT
The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.

Show MeSH
Related in: MedlinePlus