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Hematological and hepatic effects of vascular epidermal growth factor (VEGF) used to stimulate hair growth in an animal model.

Gnann LA, Castro RF, Azzalis LA, Feder D, Perazzo FF, Pereira EC, Rosa PC, Junqueira VB, Rocha KC, Machado CD, Paschoal FC, de Abreu LC, Valenti VE, Fonseca FL - BMC Dermatol. (2013)

Bottom Line: At the end of the experiment (15th day of VEGF treatment) efficacy was determined macroscopically by hair density dermatoscopy analysis, and microscopically by hair diameter analysis.On the other hand, biochemical and hematological results had shown that VEGF was not 100% inert.VEGF increased hair follicle area, but more studies are necessary to confirm its toxicity.

View Article: PubMed Central - HTML - PubMed

Affiliation: Disciplina de Farmacologia, Departamento de Morfologia, Faculdade de Medicina do ABC, Av, Príncipe de Gales, n, 821, Santo André, SP, Brazil. profferfonseca@gmail.com.

ABSTRACT

Background: Alopecia areata is the hair loss usually reversible, in sharply defined areas. The treatment of alopecia using growth factors shows interesting activity in promoting hair growth. In this concept, VEGF (vascular endothelial growth factor) is a marker of angiogenesis, stimulating hair growth by facilitating the supply of nutrients to the hair follicle, increasing follicular diameter. The aim of this study was the evaluation of a topical gel enriched with VEGF liposomes on the hair growth stimulation and its toxicological aspects.

Methods: Mesocricetus auratus were randomly divided into three groups. Control group was treated with Aristoflex® gel, 1% group with the same gel but added 1% VEGF and 3% group with 3% VEGF. Biochemical, hematological and histological analyses were done.

Results: At the end of the experiment (15th day of VEGF treatment) efficacy was determined macroscopically by hair density dermatoscopy analysis, and microscopically by hair diameter analysis. They both demonstrated that hair of the VEGF group increased faster and thicker than control. On the other hand, biochemical and hematological results had shown that VEGF was not 100% inert.

Conclusions: VEGF increased hair follicle area, but more studies are necessary to confirm its toxicity.

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Related in: MedlinePlus

Cross and longitudinal sections of control group.
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Figure 4: Cross and longitudinal sections of control group.

Mentions: Photos were taken under a digital microscope and analyzed by ImageJ®, measuring the area of each hair follicle in order to compare the area of the hair follicle of the control group, 1% VEGF and 3% VEGF (Table 2, Figures 2, 3, and 4).


Hematological and hepatic effects of vascular epidermal growth factor (VEGF) used to stimulate hair growth in an animal model.

Gnann LA, Castro RF, Azzalis LA, Feder D, Perazzo FF, Pereira EC, Rosa PC, Junqueira VB, Rocha KC, Machado CD, Paschoal FC, de Abreu LC, Valenti VE, Fonseca FL - BMC Dermatol. (2013)

Cross and longitudinal sections of control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3817933&req=5

Figure 4: Cross and longitudinal sections of control group.
Mentions: Photos were taken under a digital microscope and analyzed by ImageJ®, measuring the area of each hair follicle in order to compare the area of the hair follicle of the control group, 1% VEGF and 3% VEGF (Table 2, Figures 2, 3, and 4).

Bottom Line: At the end of the experiment (15th day of VEGF treatment) efficacy was determined macroscopically by hair density dermatoscopy analysis, and microscopically by hair diameter analysis.On the other hand, biochemical and hematological results had shown that VEGF was not 100% inert.VEGF increased hair follicle area, but more studies are necessary to confirm its toxicity.

View Article: PubMed Central - HTML - PubMed

Affiliation: Disciplina de Farmacologia, Departamento de Morfologia, Faculdade de Medicina do ABC, Av, Príncipe de Gales, n, 821, Santo André, SP, Brazil. profferfonseca@gmail.com.

ABSTRACT

Background: Alopecia areata is the hair loss usually reversible, in sharply defined areas. The treatment of alopecia using growth factors shows interesting activity in promoting hair growth. In this concept, VEGF (vascular endothelial growth factor) is a marker of angiogenesis, stimulating hair growth by facilitating the supply of nutrients to the hair follicle, increasing follicular diameter. The aim of this study was the evaluation of a topical gel enriched with VEGF liposomes on the hair growth stimulation and its toxicological aspects.

Methods: Mesocricetus auratus were randomly divided into three groups. Control group was treated with Aristoflex® gel, 1% group with the same gel but added 1% VEGF and 3% group with 3% VEGF. Biochemical, hematological and histological analyses were done.

Results: At the end of the experiment (15th day of VEGF treatment) efficacy was determined macroscopically by hair density dermatoscopy analysis, and microscopically by hair diameter analysis. They both demonstrated that hair of the VEGF group increased faster and thicker than control. On the other hand, biochemical and hematological results had shown that VEGF was not 100% inert.

Conclusions: VEGF increased hair follicle area, but more studies are necessary to confirm its toxicity.

Show MeSH
Related in: MedlinePlus