Systems biology in vaccine design.
Bottom Line: Vaccines are the most effective tools to prevent infectious diseases and to minimize their impact on humans or animals.Despite the successful development of vaccines that are able to elicit potent and protective immune responses, the majority of vaccines have been so far developed empirically and mechanistic events leading to protective immune responses are often poorly understood.This hampers the development of new prophylactic as well as therapeutic vaccines for infectious diseases and cancer.
Affiliation: UPMC Univ Paris 06, UMR 7211, F-75013 Paris, France. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: Vaccines are currently most effective treatments in preventing a number of infectious diseases and minimizing their impact on human or animal populations. A vaccine is a biological preparation that improves immunity to a particular disease upon administration to an animal/human. A vaccine typically contains one or several antigens that resemble a disease‐causing microorganism, and is often made from weakened or killed forms of the microbe or its derived antigenic proteins or its toxins + adjuvant. The antigens stimulate the body's immune system to recognize the agent as foreign, induces specific immune responses (immunogenicity). Vaccines can be prophylactic (e.g. to prevent or reduce the effects of a future infection by any natural pathogen), or therapeutic (e.g. vaccines against cancer). An ideal vaccine must have particular biological and physical characteristics, and vaccine development must gain from new technology advances (Levine and Sztein, 2004).
Affiliation: UPMC Univ Paris 06, UMR 7211, F-75013 Paris, France. email@example.com