The role of the cell wall in fungal pathogenesis.
Bottom Line: Specific components of the cell wall (called PAMPs) interact with specific receptors in the immune cell (called PRRs), triggering responses whose molecular mechanisms are being elucidated.We review here the main structural carbohydrate components of the fungal wall (glucan, mannan and chitin), how their biogenesis takes place in fungi and the specific receptors that they interact with.Different model fungal pathogens are chosen to illustrate the functional consequences of this interaction.
Affiliation: Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, E-28040 Madrid, Spain.Show MeSH
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Mentions: Recognition of pathogens by the innate immunity requires the identification of Pathogen‐Associated Molecular Patterns (PAMPs). These structures represent surface determinants that are absent in mammalian cells and are sensed by specific structures (called Pattern Recognition Receptors PRRs) present on the surface of the immune cells (Underhill and Ozinsky, 2002; Underhill, 2004). Different PRRs recognize different PAMPs and contribute in this way to the generation of a balanced response against microorganisms (Underhill, 2003b) (Fig. 2).
Affiliation: Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, E-28040 Madrid, Spain.