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Subjective health status and health-related quality of life among women with Recurrent Vulvovaginal Candidosis (RVVC) in Europe and the USA.

Aballéa S, Guelfucci F, Wagner J, Khemiri A, Dietz JP, Sobel J, Toumi M - Health Qual Life Outcomes (2013)

Bottom Line: All SF-36 domain scores were significantly below general population norms.Subjective health status and HRQoL during and in between acute inflammatory episodes in women with RVVC are significantly worse than in the general population, despite the use of antifungal therapy.The survey also revealed a significant loss of productivity associated with RVVC.

View Article: PubMed Central - HTML - PubMed

Affiliation: Université Lyon I, decision sciences and health policies, Lyon, France. saballea@gmail.com.

ABSTRACT

Background: Recurrent vulvovaginal candidosis (RVVC) is a chronic condition causing discomfort and pain. Health status and health-related quality of life (HRQoL) in RVVC were never previously described using validated questionnaires. The objective of this study is to describe subjective health status and HRQoL and estimate health state utilities among women with RVVC.

Methods: A cross-sectional online survey was conducted among women who reported having suffered four or more yeast infections over the past 12 months, in five European countries (France, Germany, Italy, Spain and the UK) and the USA. Index scores were derived from the EQ-5D, a questionnaire providing a single index value for health status. The SF-36 questionnaire was used for HRQoL assessment. Information on disease severity, treatment patterns and productivity was also collected.

Results: 12,834 members of online research panels were contacted. Among them, 620 women with RVVC (5%) were selected to complete the full questionnaire. The mean EQ-5D index score was 0.70 (95% confidence interval: [0.67, 0.72]) and the difference between women with a yeast infection at the time of questionnaire completion and other respondents was 0.05 (p = 0.47). The EQ-5D index score increased significantly with the time since last infection (p < 0.001). 68% of women reported depression/anxiety problems during acute episode, and 54% outside episodes, compared to less than 20% in general population (p < 0.001). All SF-36 domain scores were significantly below general population norms. Mental health domains were the most affected. The impact on productivity was estimated at 33 lost work hours per year on average, corresponding to estimated costs between €266/year and €1,130/year depending on the country.

Conclusions: Subjective health status and HRQoL during and in between acute inflammatory episodes in women with RVVC are significantly worse than in the general population, despite the use of antifungal therapy. The average index score in women with RVVC is comparable to other diseases such as asthma or COPD and worse than diseases such as headache/migraine according to US and UK catalogs of index scores. The survey also revealed a significant loss of productivity associated with RVVC.

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Related in: MedlinePlus

SF-36 T-scores for each dimension. All scales in the general population have the same average (50) and the same standard deviation (10).
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Figure 2: SF-36 T-scores for each dimension. All scales in the general population have the same average (50) and the same standard deviation (10).

Mentions: All SF-36 domain scores, presented in the Figure 2, were significantly lower among women with RVVC than in the general population. Results were homogeneous across countries with T-scores varying from 34 to 37 for mental health scores and from 45 to 46 for the pain scores. The most significantly affected domains were those related to mental health, particularly the “emotional well-being” and “role limitation emotional” domains. The average mental component summary score was estimated at 34.72 (95% CI: [33.74; 35.71]).


Subjective health status and health-related quality of life among women with Recurrent Vulvovaginal Candidosis (RVVC) in Europe and the USA.

Aballéa S, Guelfucci F, Wagner J, Khemiri A, Dietz JP, Sobel J, Toumi M - Health Qual Life Outcomes (2013)

SF-36 T-scores for each dimension. All scales in the general population have the same average (50) and the same standard deviation (10).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3815627&req=5

Figure 2: SF-36 T-scores for each dimension. All scales in the general population have the same average (50) and the same standard deviation (10).
Mentions: All SF-36 domain scores, presented in the Figure 2, were significantly lower among women with RVVC than in the general population. Results were homogeneous across countries with T-scores varying from 34 to 37 for mental health scores and from 45 to 46 for the pain scores. The most significantly affected domains were those related to mental health, particularly the “emotional well-being” and “role limitation emotional” domains. The average mental component summary score was estimated at 34.72 (95% CI: [33.74; 35.71]).

Bottom Line: All SF-36 domain scores were significantly below general population norms.Subjective health status and HRQoL during and in between acute inflammatory episodes in women with RVVC are significantly worse than in the general population, despite the use of antifungal therapy.The survey also revealed a significant loss of productivity associated with RVVC.

View Article: PubMed Central - HTML - PubMed

Affiliation: Université Lyon I, decision sciences and health policies, Lyon, France. saballea@gmail.com.

ABSTRACT

Background: Recurrent vulvovaginal candidosis (RVVC) is a chronic condition causing discomfort and pain. Health status and health-related quality of life (HRQoL) in RVVC were never previously described using validated questionnaires. The objective of this study is to describe subjective health status and HRQoL and estimate health state utilities among women with RVVC.

Methods: A cross-sectional online survey was conducted among women who reported having suffered four or more yeast infections over the past 12 months, in five European countries (France, Germany, Italy, Spain and the UK) and the USA. Index scores were derived from the EQ-5D, a questionnaire providing a single index value for health status. The SF-36 questionnaire was used for HRQoL assessment. Information on disease severity, treatment patterns and productivity was also collected.

Results: 12,834 members of online research panels were contacted. Among them, 620 women with RVVC (5%) were selected to complete the full questionnaire. The mean EQ-5D index score was 0.70 (95% confidence interval: [0.67, 0.72]) and the difference between women with a yeast infection at the time of questionnaire completion and other respondents was 0.05 (p = 0.47). The EQ-5D index score increased significantly with the time since last infection (p < 0.001). 68% of women reported depression/anxiety problems during acute episode, and 54% outside episodes, compared to less than 20% in general population (p < 0.001). All SF-36 domain scores were significantly below general population norms. Mental health domains were the most affected. The impact on productivity was estimated at 33 lost work hours per year on average, corresponding to estimated costs between €266/year and €1,130/year depending on the country.

Conclusions: Subjective health status and HRQoL during and in between acute inflammatory episodes in women with RVVC are significantly worse than in the general population, despite the use of antifungal therapy. The average index score in women with RVVC is comparable to other diseases such as asthma or COPD and worse than diseases such as headache/migraine according to US and UK catalogs of index scores. The survey also revealed a significant loss of productivity associated with RVVC.

Show MeSH
Related in: MedlinePlus