Natural products for cancer chemotherapy.
Bottom Line: A vast array of biological metabolites can be obtained from the marine world, which can be used for effective cancer treatment.In addition, the high toxicity usually associated with some cancer chemotherapy drugs and their undesirable side-effects increase the demand for novel anti-tumour drugs active against untreatable tumours, with fewer side-effects and/or with greater therapeutic efficiency.This review points out those technologies needed to produce the anti-tumour compounds of the future.
Affiliation: Charles A Dana Research Institute for Scientists Emeriti, Drew University, Madison, NJ 07940, USA. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: In their review on the use of microbes to prescreen potential anti‐tumour compounds, Newman and Shapiro (2008) concluded that microorganisms have played an important role in identifying compounds with therapeutic benefit against cancer. Most of the important compounds used for chemotherapy of tumours are microbially produced antibiotics or their derivatives. Some of the microbial anti‐tumour agents are shown in Table 1. One of the earliest applications of a microbial product was actinomycin D for Wilm's tumour in children. Use of this compound against stage I or stage II Wilm's tumour has resulted in a 90% survival rate (Chung, 2009). The structures of some of the most useful anti‐tumour compounds are shown in Fig. 1 (Salas and Mendez, 1998). Also used for anti‐tumour therapy is the enzyme l‐asparaginase.
Affiliation: Charles A Dana Research Institute for Scientists Emeriti, Drew University, Madison, NJ 07940, USA. email@example.com