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A functional variant rs1820453 in YAP1 and breast cancer risk in Chinese population.

Chen W, Wang W, Zhu B, Guo H, Sun Y, Ming J, Shen N, Li Z, Wang Z, Liu L, Cai B, Duan J, Li J, Liu C, Zhong R, Hu W, Huang T, Miao X - PLoS ONE (2013)

Bottom Line: The association between rs1820453 and BC risk was significantly identified with the odds ratio (OR) was 1.27 (95 % confidence interval (CI) =1.03-1.57) under allelic model when adjusted by age and menopausal status.In addition, the correlation analysis of rs1820453 and YAP1 expression level found that this variant was significantly associated with the gene expression in Chinese population.The results from this study suggested that rs1820453 A>C change may affect the gene expression and contribute to the risk of developing BC in Chinese population though larger sample-size studies along with functional experiments were anticipated to warrant the results.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Environment Health ( Incubation), Ministry of Education Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

ABSTRACT

Background: To investigate the association between rs1820453 which located in the promoter region of yes-associated protein 1 (YAP1) gene and breast cancer (BC) risk.

Method and findings: We conducted a hospital-based case-control study including a total of 480 BC cases and 545 cancer-free controls in Chinese population. Then the expression quantitative trait locus (e-QTL) analysis was performed to explore the possible function of rs1820453 to the YAP1 gene expression. The association between rs1820453 and BC risk was significantly identified with the odds ratio (OR) was 1.27 (95 % confidence interval (CI) =1.03-1.57) under allelic model when adjusted by age and menopausal status. In addition, the correlation analysis of rs1820453 and YAP1 expression level found that this variant was significantly associated with the gene expression in Chinese population. When compared with level of mRNA expression of the AA genotype (6.011 ± 0.046), the mRNA expression level in CC genotype (5.903 ± 0.026) was statistically lower (P=0.024).

Conclusion: The results from this study suggested that rs1820453 A>C change may affect the gene expression and contribute to the risk of developing BC in Chinese population though larger sample-size studies along with functional experiments were anticipated to warrant the results.

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Related in: MedlinePlus

The mRNA expression level of YAP1 gene in unrelated CHB.
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pone-0079056-g001: The mRNA expression level of YAP1 gene in unrelated CHB.

Mentions: The correlation analysis of rs1820453 and YAP1 mRNA expression in 44 (1 missing) unrelated Chinese Han population found that when compared with the levels of mRNA expression in 26 cell lines with rs1820453 AA genotype (6.011±0.046), 2 cell lines with the CC genotype had statistically lower levels of mRNA expression (5.903±0.026, P= 0.024) (Figure 1). However, we did not identify significant association of YAP1 mRNA expression and rs1820453 in the 270 all population HapMap lymphoblastoid cell lines with the mRNA expression levels in 129 cell lines with AA genotype, 102 cell lines with AC genotype and 37 cell lines with CC genotype were 6.079±0.060, 6.073±0.085, and 6.087±0.085; respectively (Figure 2). The all results suggested that rs1820453 A>C change may be the risk factor for BC susceptibility in Chinese through influencing the YAP1 gene expression.


A functional variant rs1820453 in YAP1 and breast cancer risk in Chinese population.

Chen W, Wang W, Zhu B, Guo H, Sun Y, Ming J, Shen N, Li Z, Wang Z, Liu L, Cai B, Duan J, Li J, Liu C, Zhong R, Hu W, Huang T, Miao X - PLoS ONE (2013)

The mRNA expression level of YAP1 gene in unrelated CHB.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3815349&req=5

pone-0079056-g001: The mRNA expression level of YAP1 gene in unrelated CHB.
Mentions: The correlation analysis of rs1820453 and YAP1 mRNA expression in 44 (1 missing) unrelated Chinese Han population found that when compared with the levels of mRNA expression in 26 cell lines with rs1820453 AA genotype (6.011±0.046), 2 cell lines with the CC genotype had statistically lower levels of mRNA expression (5.903±0.026, P= 0.024) (Figure 1). However, we did not identify significant association of YAP1 mRNA expression and rs1820453 in the 270 all population HapMap lymphoblastoid cell lines with the mRNA expression levels in 129 cell lines with AA genotype, 102 cell lines with AC genotype and 37 cell lines with CC genotype were 6.079±0.060, 6.073±0.085, and 6.087±0.085; respectively (Figure 2). The all results suggested that rs1820453 A>C change may be the risk factor for BC susceptibility in Chinese through influencing the YAP1 gene expression.

Bottom Line: The association between rs1820453 and BC risk was significantly identified with the odds ratio (OR) was 1.27 (95 % confidence interval (CI) =1.03-1.57) under allelic model when adjusted by age and menopausal status.In addition, the correlation analysis of rs1820453 and YAP1 expression level found that this variant was significantly associated with the gene expression in Chinese population.The results from this study suggested that rs1820453 A>C change may affect the gene expression and contribute to the risk of developing BC in Chinese population though larger sample-size studies along with functional experiments were anticipated to warrant the results.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Environment Health ( Incubation), Ministry of Education Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

ABSTRACT

Background: To investigate the association between rs1820453 which located in the promoter region of yes-associated protein 1 (YAP1) gene and breast cancer (BC) risk.

Method and findings: We conducted a hospital-based case-control study including a total of 480 BC cases and 545 cancer-free controls in Chinese population. Then the expression quantitative trait locus (e-QTL) analysis was performed to explore the possible function of rs1820453 to the YAP1 gene expression. The association between rs1820453 and BC risk was significantly identified with the odds ratio (OR) was 1.27 (95 % confidence interval (CI) =1.03-1.57) under allelic model when adjusted by age and menopausal status. In addition, the correlation analysis of rs1820453 and YAP1 expression level found that this variant was significantly associated with the gene expression in Chinese population. When compared with level of mRNA expression of the AA genotype (6.011 ± 0.046), the mRNA expression level in CC genotype (5.903 ± 0.026) was statistically lower (P=0.024).

Conclusion: The results from this study suggested that rs1820453 A>C change may affect the gene expression and contribute to the risk of developing BC in Chinese population though larger sample-size studies along with functional experiments were anticipated to warrant the results.

Show MeSH
Related in: MedlinePlus