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Examination of cognitive fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging.

Genova HM, Rajagopalan V, Deluca J, Das A, Binder A, Arjunan A, Chiaravalloti N, Wylie G - PLoS ONE (2013)

Bottom Line: During the cognitively fatiguing task, the MS group had increased brain activity associated with fatigue in the caudate as compared with HCs.DTI findings revealed that reduced fractional anisotropy in the anterior internal capsule was associated with increased self-reported fatigue on the FSS.Results are discussed in terms of identifying a "fatigue-network" in MS.

View Article: PubMed Central - PubMed

Affiliation: Neuropsychology and Neuroscience Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America ; Department of Physical Medicine and Rehabilitation, Rutgers, New Jersey Medical School, Newark, New Jersey, United States of America.

ABSTRACT
The present study investigated the neural correlates of cognitive fatigue in Multiple Sclerosis (MS), looking specifically at the relationship between self-reported fatigue and objective measures of cognitive fatigue. In Experiment 1, functional magnetic resonance imaging (fMRI) was used to examine where in the brain BOLD activity covaried with "state" fatigue, assessed during performance of a task designed to induce cognitive fatigue while in the scanner. In Experiment 2, diffusion tensor imaging (DTI) was used to examine where in the brain white matter damage correlated with increased "trait" fatigue in individuals with MS, assessed by the Fatigue Severity Scale (FSS) completed outside the scanning session. During the cognitively fatiguing task, the MS group had increased brain activity associated with fatigue in the caudate as compared with HCs. DTI findings revealed that reduced fractional anisotropy in the anterior internal capsule was associated with increased self-reported fatigue on the FSS. Results are discussed in terms of identifying a "fatigue-network" in MS.

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Related in: MedlinePlus

Caudate activity greater in MS group relative to HCs.Figure 3. shows activation in the caudate which was greater in the MS group compared to HCs.
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pone-0078811-g003: Caudate activity greater in MS group relative to HCs.Figure 3. shows activation in the caudate which was greater in the MS group compared to HCs.

Mentions: Because of the role of the striatal-thalamic-frontal cortical system in fatigue [10,12], we performed ROI analyses on the basal ganglia, thalamus and frontal lobes, in which we compared the fatigue-related activation across the two groups (i.e., MS – HC). These analyses revealed a cluster in the caudate (See Figure 3; caudate tail: 20, -42, 16) that was significantly more active in the MS group (p < .01,) compared to HCs.


Examination of cognitive fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging.

Genova HM, Rajagopalan V, Deluca J, Das A, Binder A, Arjunan A, Chiaravalloti N, Wylie G - PLoS ONE (2013)

Caudate activity greater in MS group relative to HCs.Figure 3. shows activation in the caudate which was greater in the MS group compared to HCs.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3815348&req=5

pone-0078811-g003: Caudate activity greater in MS group relative to HCs.Figure 3. shows activation in the caudate which was greater in the MS group compared to HCs.
Mentions: Because of the role of the striatal-thalamic-frontal cortical system in fatigue [10,12], we performed ROI analyses on the basal ganglia, thalamus and frontal lobes, in which we compared the fatigue-related activation across the two groups (i.e., MS – HC). These analyses revealed a cluster in the caudate (See Figure 3; caudate tail: 20, -42, 16) that was significantly more active in the MS group (p < .01,) compared to HCs.

Bottom Line: During the cognitively fatiguing task, the MS group had increased brain activity associated with fatigue in the caudate as compared with HCs.DTI findings revealed that reduced fractional anisotropy in the anterior internal capsule was associated with increased self-reported fatigue on the FSS.Results are discussed in terms of identifying a "fatigue-network" in MS.

View Article: PubMed Central - PubMed

Affiliation: Neuropsychology and Neuroscience Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America ; Department of Physical Medicine and Rehabilitation, Rutgers, New Jersey Medical School, Newark, New Jersey, United States of America.

ABSTRACT
The present study investigated the neural correlates of cognitive fatigue in Multiple Sclerosis (MS), looking specifically at the relationship between self-reported fatigue and objective measures of cognitive fatigue. In Experiment 1, functional magnetic resonance imaging (fMRI) was used to examine where in the brain BOLD activity covaried with "state" fatigue, assessed during performance of a task designed to induce cognitive fatigue while in the scanner. In Experiment 2, diffusion tensor imaging (DTI) was used to examine where in the brain white matter damage correlated with increased "trait" fatigue in individuals with MS, assessed by the Fatigue Severity Scale (FSS) completed outside the scanning session. During the cognitively fatiguing task, the MS group had increased brain activity associated with fatigue in the caudate as compared with HCs. DTI findings revealed that reduced fractional anisotropy in the anterior internal capsule was associated with increased self-reported fatigue on the FSS. Results are discussed in terms of identifying a "fatigue-network" in MS.

Show MeSH
Related in: MedlinePlus