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Examination of cognitive fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging.

Genova HM, Rajagopalan V, Deluca J, Das A, Binder A, Arjunan A, Chiaravalloti N, Wylie G - PLoS ONE (2013)

Bottom Line: During the cognitively fatiguing task, the MS group had increased brain activity associated with fatigue in the caudate as compared with HCs.DTI findings revealed that reduced fractional anisotropy in the anterior internal capsule was associated with increased self-reported fatigue on the FSS.Results are discussed in terms of identifying a "fatigue-network" in MS.

View Article: PubMed Central - PubMed

Affiliation: Neuropsychology and Neuroscience Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America ; Department of Physical Medicine and Rehabilitation, Rutgers, New Jersey Medical School, Newark, New Jersey, United States of America.

ABSTRACT
The present study investigated the neural correlates of cognitive fatigue in Multiple Sclerosis (MS), looking specifically at the relationship between self-reported fatigue and objective measures of cognitive fatigue. In Experiment 1, functional magnetic resonance imaging (fMRI) was used to examine where in the brain BOLD activity covaried with "state" fatigue, assessed during performance of a task designed to induce cognitive fatigue while in the scanner. In Experiment 2, diffusion tensor imaging (DTI) was used to examine where in the brain white matter damage correlated with increased "trait" fatigue in individuals with MS, assessed by the Fatigue Severity Scale (FSS) completed outside the scanning session. During the cognitively fatiguing task, the MS group had increased brain activity associated with fatigue in the caudate as compared with HCs. DTI findings revealed that reduced fractional anisotropy in the anterior internal capsule was associated with increased self-reported fatigue on the FSS. Results are discussed in terms of identifying a "fatigue-network" in MS.

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Fatigue across run for MS and HC group.Experiment 1: Results of group (2) x run (7) mixed design ANCOVA (age as covariate) examining self-reported VAS ratings of fatigue across 7 runs of fMRI cognitive task. MS group reported more fatigue relative to the HC group but there was no significant group x time interaction.
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pone-0078811-g002: Fatigue across run for MS and HC group.Experiment 1: Results of group (2) x run (7) mixed design ANCOVA (age as covariate) examining self-reported VAS ratings of fatigue across 7 runs of fMRI cognitive task. MS group reported more fatigue relative to the HC group but there was no significant group x time interaction.

Mentions: The VAS fatigue ratings were analyzed using a 2 x 7 mixed design ANCOVA, with group (MS vs. HC) as the between-groups factor and run (runs 1 to 6; NB, there are seven levels to this factor because ratings were acquired before and after each of the six runs) as the within-subjects factor, age was added as a covariate. Mauchly's test of Sphericity showed that the sphericity assumption did not hold and adjusted degrees of freedom were therefore used (Greenhouse Geisser correction). There was no significant main effect of run (F(2.82, 56.41)=.823). The main effect of group was significant (F(1,20)=6.52, p=.019) with the MS group reporting more fatigue relative to the HC group (see Figure 2). However, the group by time interaction was not significant (F(2.82, 56.41)=.754).


Examination of cognitive fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging.

Genova HM, Rajagopalan V, Deluca J, Das A, Binder A, Arjunan A, Chiaravalloti N, Wylie G - PLoS ONE (2013)

Fatigue across run for MS and HC group.Experiment 1: Results of group (2) x run (7) mixed design ANCOVA (age as covariate) examining self-reported VAS ratings of fatigue across 7 runs of fMRI cognitive task. MS group reported more fatigue relative to the HC group but there was no significant group x time interaction.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3815348&req=5

pone-0078811-g002: Fatigue across run for MS and HC group.Experiment 1: Results of group (2) x run (7) mixed design ANCOVA (age as covariate) examining self-reported VAS ratings of fatigue across 7 runs of fMRI cognitive task. MS group reported more fatigue relative to the HC group but there was no significant group x time interaction.
Mentions: The VAS fatigue ratings were analyzed using a 2 x 7 mixed design ANCOVA, with group (MS vs. HC) as the between-groups factor and run (runs 1 to 6; NB, there are seven levels to this factor because ratings were acquired before and after each of the six runs) as the within-subjects factor, age was added as a covariate. Mauchly's test of Sphericity showed that the sphericity assumption did not hold and adjusted degrees of freedom were therefore used (Greenhouse Geisser correction). There was no significant main effect of run (F(2.82, 56.41)=.823). The main effect of group was significant (F(1,20)=6.52, p=.019) with the MS group reporting more fatigue relative to the HC group (see Figure 2). However, the group by time interaction was not significant (F(2.82, 56.41)=.754).

Bottom Line: During the cognitively fatiguing task, the MS group had increased brain activity associated with fatigue in the caudate as compared with HCs.DTI findings revealed that reduced fractional anisotropy in the anterior internal capsule was associated with increased self-reported fatigue on the FSS.Results are discussed in terms of identifying a "fatigue-network" in MS.

View Article: PubMed Central - PubMed

Affiliation: Neuropsychology and Neuroscience Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America ; Department of Physical Medicine and Rehabilitation, Rutgers, New Jersey Medical School, Newark, New Jersey, United States of America.

ABSTRACT
The present study investigated the neural correlates of cognitive fatigue in Multiple Sclerosis (MS), looking specifically at the relationship between self-reported fatigue and objective measures of cognitive fatigue. In Experiment 1, functional magnetic resonance imaging (fMRI) was used to examine where in the brain BOLD activity covaried with "state" fatigue, assessed during performance of a task designed to induce cognitive fatigue while in the scanner. In Experiment 2, diffusion tensor imaging (DTI) was used to examine where in the brain white matter damage correlated with increased "trait" fatigue in individuals with MS, assessed by the Fatigue Severity Scale (FSS) completed outside the scanning session. During the cognitively fatiguing task, the MS group had increased brain activity associated with fatigue in the caudate as compared with HCs. DTI findings revealed that reduced fractional anisotropy in the anterior internal capsule was associated with increased self-reported fatigue on the FSS. Results are discussed in terms of identifying a "fatigue-network" in MS.

Show MeSH
Related in: MedlinePlus