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Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study.

Okayama S, Nakano T, Uemura S, Fujimoto S, Somekawa S, Watanabe M, Nakajima T, Saito Y - J Cardiovasc Magn Reson (2013)

Bottom Line: Normal, impaired relaxation, pseudonormal, and restrictive LV filling were observed in 15, 28, 11, and 5 patients, respectively.The diastolic index was significantly lower (p < 0.0001) in patients with impaired relaxation (32.4 ± 7.5), pseudonormal filling (25.4 ± 5.6), and restrictive filling (9.5 ± 1.5) compared to those with normal diastolic function (67.7 ± 10.8), and the index decreased significantly with worsening of diastolic dysfunction.The diastolic index correlated positively with early diastolic mitral annular velocity measured by tissue Doppler imaging (r = 0.75, p < 0.0001), respectively.

View Article: PubMed Central - HTML - PubMed

Affiliation: First Department of Internal Medicine, Nara Medical University, Nara, Japan. satosi01@naramed-u.ac.jp.

ABSTRACT

Background: Evaluation of left ventricular (LV) diastolic function is essential for the management of heart failure. We verified whether LV diastolic function could be evaluated by measuring the fractional area change (FAC) using cine cardiovascular magnetic resonance (CMR).

Methods: We collected clinical data from 59 patients who underwent echocardiography and cine CMR. Normal, impaired relaxation, pseudonormal, and restrictive LV filling were observed in 15, 28, 11, and 5 patients, respectively. We calculated FAC during the first 30% of diastole (diastolic-index%) in the short-axis view, by tracing the contours on only three MR cine images.

Results: The diastolic index was significantly lower (p < 0.0001) in patients with impaired relaxation (32.4 ± 7.5), pseudonormal filling (25.4 ± 5.6), and restrictive filling (9.5 ± 1.5) compared to those with normal diastolic function (67.7 ± 10.8), and the index decreased significantly with worsening of diastolic dysfunction. The diastolic index correlated positively with early diastolic mitral annular velocity measured by tissue Doppler imaging (r = 0.75, p < 0.0001), respectively.

Conclusions: Measurement of FAC can be useful for the evaluation of LV diastolic function using cine CMR.

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The association between the left ventricular (LV) systolic and diastolic indexes and conventional echocardiography cardiac function measurements. The LV systolic index well positively correlated with ejection fraction (EF), and the diastolic index moderately positively correlated with early diastolic mitral annular velocity (Ea) and negatively with the ratio of peak early filling velocity divided by Ea (E/Ea).
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Figure 3: The association between the left ventricular (LV) systolic and diastolic indexes and conventional echocardiography cardiac function measurements. The LV systolic index well positively correlated with ejection fraction (EF), and the diastolic index moderately positively correlated with early diastolic mitral annular velocity (Ea) and negatively with the ratio of peak early filling velocity divided by Ea (E/Ea).

Mentions: Figure 3 shows the association between the LV systolic and diastolic indexes and conventional echocardiographic cardiac function measurements. The systolic index showed good positive correlation with EF (r = 0.85, p < 0.0001), whereas the diastolic index showed moderate positive correlation with Ea (r = 0.75, p < 0.0001) and negative correlation with E/Ea (r = 0.58, p < 0.0001), but no correlation with E/A (p = 0.14) and DCT (p = 0.35). The reduction of diastolic index was closely associated with the progression of LV diastolic dysfunction.


Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study.

Okayama S, Nakano T, Uemura S, Fujimoto S, Somekawa S, Watanabe M, Nakajima T, Saito Y - J Cardiovasc Magn Reson (2013)

The association between the left ventricular (LV) systolic and diastolic indexes and conventional echocardiography cardiac function measurements. The LV systolic index well positively correlated with ejection fraction (EF), and the diastolic index moderately positively correlated with early diastolic mitral annular velocity (Ea) and negatively with the ratio of peak early filling velocity divided by Ea (E/Ea).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3815234&req=5

Figure 3: The association between the left ventricular (LV) systolic and diastolic indexes and conventional echocardiography cardiac function measurements. The LV systolic index well positively correlated with ejection fraction (EF), and the diastolic index moderately positively correlated with early diastolic mitral annular velocity (Ea) and negatively with the ratio of peak early filling velocity divided by Ea (E/Ea).
Mentions: Figure 3 shows the association between the LV systolic and diastolic indexes and conventional echocardiographic cardiac function measurements. The systolic index showed good positive correlation with EF (r = 0.85, p < 0.0001), whereas the diastolic index showed moderate positive correlation with Ea (r = 0.75, p < 0.0001) and negative correlation with E/Ea (r = 0.58, p < 0.0001), but no correlation with E/A (p = 0.14) and DCT (p = 0.35). The reduction of diastolic index was closely associated with the progression of LV diastolic dysfunction.

Bottom Line: Normal, impaired relaxation, pseudonormal, and restrictive LV filling were observed in 15, 28, 11, and 5 patients, respectively.The diastolic index was significantly lower (p < 0.0001) in patients with impaired relaxation (32.4 ± 7.5), pseudonormal filling (25.4 ± 5.6), and restrictive filling (9.5 ± 1.5) compared to those with normal diastolic function (67.7 ± 10.8), and the index decreased significantly with worsening of diastolic dysfunction.The diastolic index correlated positively with early diastolic mitral annular velocity measured by tissue Doppler imaging (r = 0.75, p < 0.0001), respectively.

View Article: PubMed Central - HTML - PubMed

Affiliation: First Department of Internal Medicine, Nara Medical University, Nara, Japan. satosi01@naramed-u.ac.jp.

ABSTRACT

Background: Evaluation of left ventricular (LV) diastolic function is essential for the management of heart failure. We verified whether LV diastolic function could be evaluated by measuring the fractional area change (FAC) using cine cardiovascular magnetic resonance (CMR).

Methods: We collected clinical data from 59 patients who underwent echocardiography and cine CMR. Normal, impaired relaxation, pseudonormal, and restrictive LV filling were observed in 15, 28, 11, and 5 patients, respectively. We calculated FAC during the first 30% of diastole (diastolic-index%) in the short-axis view, by tracing the contours on only three MR cine images.

Results: The diastolic index was significantly lower (p < 0.0001) in patients with impaired relaxation (32.4 ± 7.5), pseudonormal filling (25.4 ± 5.6), and restrictive filling (9.5 ± 1.5) compared to those with normal diastolic function (67.7 ± 10.8), and the index decreased significantly with worsening of diastolic dysfunction. The diastolic index correlated positively with early diastolic mitral annular velocity measured by tissue Doppler imaging (r = 0.75, p < 0.0001), respectively.

Conclusions: Measurement of FAC can be useful for the evaluation of LV diastolic function using cine CMR.

Show MeSH
Related in: MedlinePlus