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Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9,156 patients.

Schwentner L, Wöckel A, König J, Janni W, Ebner F, Blettner M, Kreienberg R, Van Ewijk R, Brenda study gro - BMC Cancer (2013)

Bottom Line: The rates of guideline adherence are significantly lower in TNBC compared to non-TNBC subtypes.In TNBC patients of all age groups, disease-free survival and overall survival were associated with an improvement by 100% guideline-adherent adjuvant treatment compared to non-adherence.The rates of guideline-adherent treatment were significantly lower in TNBC, even though guideline adherence was strongly associated with improved survival.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Gynecology and Obstetrics, University Ulm, Prittwitzstraße 43, Ulm 89075, Germany. lukas.schwentner@yahoo.de.

ABSTRACT

Background: Triple-negative breast cancer (TNBC) remains a challenging topic for clinical oncologists. This study sought to evaluate TNBC versus other breast cancer subtypes with respect to survival parameters. We evaluated possible differences in survival in TNBC by age and by the extent to which evidence-based treatment guidelines were adhered.

Methods: This German retrospective multi-center cohort study included 9156 patients with primary breast cancer recruited from 1992 to 2008.

Results: The rates of guideline adherence are significantly lower in TNBC compared to non-TNBC subtypes. These lower rates of guideline adherence can be observed in all age groups and are most pronounced in the >65 subgroup [<50 (20.9% vs. 42.0%), 50-64 (25.1% vs. 51.1%), and >65 (38.4% vs. 74.6%)]. In TNBC patients of all age groups, disease-free survival and overall survival were associated with an improvement by 100% guideline-adherent adjuvant treatment compared to non-adherence. Furthermore, TNBC patients of all ages had similar outcome parameters if 100% guideline-adherent adjuvant treatment was applied.

Conclusion: The rates of guideline-adherent treatment were significantly lower in TNBC, even though guideline adherence was strongly associated with improved survival. In the case of 100% guideline-adherent treatment, no difference in survival was observed over all the age groups examined, even in the group of >65-year-old TNBC patients.

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Overall survival (OAS) and disease-free survival (DFS) for TNBC patients who received 100% guideline-adherent adjuvant treatment, as stratified by age (<50 n = 164; 50–64 n = 134; ≥65 n = 73) and adjusted for year of diagnosis, tumor size, grading, nodal status, menopausal status, and comorbidities.
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Figure 5: Overall survival (OAS) and disease-free survival (DFS) for TNBC patients who received 100% guideline-adherent adjuvant treatment, as stratified by age (<50 n = 164; 50–64 n = 134; ≥65 n = 73) and adjusted for year of diagnosis, tumor size, grading, nodal status, menopausal status, and comorbidities.

Mentions: We also investigated the differences between the 100% guideline-treated TNBC patients in those age groups (<50, 50–64, and ≥65). We chose the TNBC ≥65 group as a reference group and compared it to both the TNBC 50–64 [OAS, HR = 0.76; P = 0.803; DFS, HR = 1.38; P = 0.602] and <50 [OAS, HR = 1.08; P = 0.909; DFS, HR = 1.45; P = 0.331] subgroups. We did not observe a significant difference in any outcome parameter by age group under the condition of 100% guideline-adherent treatment (see Figure 5). However, if we compared all the 100% guideline-adherent TNBC patients with all the 100% guideline-adherent non-TNBC patients, we observed a significantly inferior OAS [HR = 01.84; P = 0.004] and DFS [HR = 1.55; P = 0.012] in the patients suffering from TNBC.


Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9,156 patients.

Schwentner L, Wöckel A, König J, Janni W, Ebner F, Blettner M, Kreienberg R, Van Ewijk R, Brenda study gro - BMC Cancer (2013)

Overall survival (OAS) and disease-free survival (DFS) for TNBC patients who received 100% guideline-adherent adjuvant treatment, as stratified by age (<50 n = 164; 50–64 n = 134; ≥65 n = 73) and adjusted for year of diagnosis, tumor size, grading, nodal status, menopausal status, and comorbidities.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3815231&req=5

Figure 5: Overall survival (OAS) and disease-free survival (DFS) for TNBC patients who received 100% guideline-adherent adjuvant treatment, as stratified by age (<50 n = 164; 50–64 n = 134; ≥65 n = 73) and adjusted for year of diagnosis, tumor size, grading, nodal status, menopausal status, and comorbidities.
Mentions: We also investigated the differences between the 100% guideline-treated TNBC patients in those age groups (<50, 50–64, and ≥65). We chose the TNBC ≥65 group as a reference group and compared it to both the TNBC 50–64 [OAS, HR = 0.76; P = 0.803; DFS, HR = 1.38; P = 0.602] and <50 [OAS, HR = 1.08; P = 0.909; DFS, HR = 1.45; P = 0.331] subgroups. We did not observe a significant difference in any outcome parameter by age group under the condition of 100% guideline-adherent treatment (see Figure 5). However, if we compared all the 100% guideline-adherent TNBC patients with all the 100% guideline-adherent non-TNBC patients, we observed a significantly inferior OAS [HR = 01.84; P = 0.004] and DFS [HR = 1.55; P = 0.012] in the patients suffering from TNBC.

Bottom Line: The rates of guideline adherence are significantly lower in TNBC compared to non-TNBC subtypes.In TNBC patients of all age groups, disease-free survival and overall survival were associated with an improvement by 100% guideline-adherent adjuvant treatment compared to non-adherence.The rates of guideline-adherent treatment were significantly lower in TNBC, even though guideline adherence was strongly associated with improved survival.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Gynecology and Obstetrics, University Ulm, Prittwitzstraße 43, Ulm 89075, Germany. lukas.schwentner@yahoo.de.

ABSTRACT

Background: Triple-negative breast cancer (TNBC) remains a challenging topic for clinical oncologists. This study sought to evaluate TNBC versus other breast cancer subtypes with respect to survival parameters. We evaluated possible differences in survival in TNBC by age and by the extent to which evidence-based treatment guidelines were adhered.

Methods: This German retrospective multi-center cohort study included 9156 patients with primary breast cancer recruited from 1992 to 2008.

Results: The rates of guideline adherence are significantly lower in TNBC compared to non-TNBC subtypes. These lower rates of guideline adherence can be observed in all age groups and are most pronounced in the >65 subgroup [<50 (20.9% vs. 42.0%), 50-64 (25.1% vs. 51.1%), and >65 (38.4% vs. 74.6%)]. In TNBC patients of all age groups, disease-free survival and overall survival were associated with an improvement by 100% guideline-adherent adjuvant treatment compared to non-adherence. Furthermore, TNBC patients of all ages had similar outcome parameters if 100% guideline-adherent adjuvant treatment was applied.

Conclusion: The rates of guideline-adherent treatment were significantly lower in TNBC, even though guideline adherence was strongly associated with improved survival. In the case of 100% guideline-adherent treatment, no difference in survival was observed over all the age groups examined, even in the group of >65-year-old TNBC patients.

Show MeSH
Related in: MedlinePlus