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Recurrence of preeclampsia in northern Tanzania: a registry-based cohort study.

Mahande MJ, Daltveit AK, Mmbaga BT, Masenga G, Obure J, Manongi R, Lie RT - PLoS ONE (2013)

Bottom Line: A total of 3,909 women were recorded with subsequent deliveries in the hospital with follow up through 2010.These include perinatal death (RR= 4.3), a baby with low birth weight (RR= 3.5), or a preterm birth (RR= 2.5).Women with previous preeclampsia may benefit from close follow-up during their pregnancies.

View Article: PubMed Central - PubMed

Affiliation: Kilimanjaro Christian Medical University College, Moshi, Tanzania ; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway ; Centre for International Health, University of Bergen, Bergen, Norway.

ABSTRACT

Objective: Preeclampsia occurs in about 4 per cent of pregnancies worldwide, and may have particularly serious consequences for women in Africa. Studies in western countries have shown that women with preeclampsia in one pregnancy have a substantially increased risk of preeclampsia in subsequent pregnancies. We estimate the recurrence risks of preeclampsia in data from Northern Tanzania.

Methods: A prospective cohort study was designed using 19,811 women who delivered singleton infants at a hospital in Northern Tanzania between 2000 and 2008. A total of 3,909 women were recorded with subsequent deliveries in the hospital with follow up through 2010. Adjusted recurrence risks of preeclampsia were computed using regression models.

Results: The absolute recurrence risk of preeclampsia was 25%, which was 9.2-fold (95% CI: 6.4 - 13.2) compared with the risk for women without prior preeclampsia. When there were signs that the preeclampsia in a previous pregnancy had been serious either because the baby was delivered preterm or had died in the perinatal period, the recurrence risk of preeclampsia was even higher. Women who had preeclampsia had increased risk of a series of adverse pregnancy outcomes in future pregnancies. These include perinatal death (RR= 4.3), a baby with low birth weight (RR= 3.5), or a preterm birth (RR= 2.5). These risks were only partly explained by recurrence of preeclampsia.

Conclusions: Preeclampsia in one pregnancy is a strong predictor for preeclampsia and other adverse pregnancy outcomes in subsequent pregnancies in Tanzania. Women with previous preeclampsia may benefit from close follow-up during their pregnancies.

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Related in: MedlinePlus

Mean of mother’s body weight before the first pregnancy for women with two recorded pregnancies depending on whether each pregnancy was affected by preeclampsia.
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pone-0079116-g003: Mean of mother’s body weight before the first pregnancy for women with two recorded pregnancies depending on whether each pregnancy was affected by preeclampsia.

Mentions: High body weight is a known risk factor for preeclampsia. We explored whether body weight before first pregnancy was associated with risk of recurrence of preeclampsia. Women who went on to have two pregnancies, both affected by preeclampsia, had an average weight before the first pregnancy of 66.3 kilograms. This was not different from 65.6 kilograms for women who had preeclampsia only in the first of two pregnancies (Figure 3). There was also little difference for these two groups in weight before the second pregnancy. Although higher weight is associated with preeclampsia, future recurrent preeclampsia could not be predicted by high body weight of a woman in our data.


Recurrence of preeclampsia in northern Tanzania: a registry-based cohort study.

Mahande MJ, Daltveit AK, Mmbaga BT, Masenga G, Obure J, Manongi R, Lie RT - PLoS ONE (2013)

Mean of mother’s body weight before the first pregnancy for women with two recorded pregnancies depending on whether each pregnancy was affected by preeclampsia.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3815128&req=5

pone-0079116-g003: Mean of mother’s body weight before the first pregnancy for women with two recorded pregnancies depending on whether each pregnancy was affected by preeclampsia.
Mentions: High body weight is a known risk factor for preeclampsia. We explored whether body weight before first pregnancy was associated with risk of recurrence of preeclampsia. Women who went on to have two pregnancies, both affected by preeclampsia, had an average weight before the first pregnancy of 66.3 kilograms. This was not different from 65.6 kilograms for women who had preeclampsia only in the first of two pregnancies (Figure 3). There was also little difference for these two groups in weight before the second pregnancy. Although higher weight is associated with preeclampsia, future recurrent preeclampsia could not be predicted by high body weight of a woman in our data.

Bottom Line: A total of 3,909 women were recorded with subsequent deliveries in the hospital with follow up through 2010.These include perinatal death (RR= 4.3), a baby with low birth weight (RR= 3.5), or a preterm birth (RR= 2.5).Women with previous preeclampsia may benefit from close follow-up during their pregnancies.

View Article: PubMed Central - PubMed

Affiliation: Kilimanjaro Christian Medical University College, Moshi, Tanzania ; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway ; Centre for International Health, University of Bergen, Bergen, Norway.

ABSTRACT

Objective: Preeclampsia occurs in about 4 per cent of pregnancies worldwide, and may have particularly serious consequences for women in Africa. Studies in western countries have shown that women with preeclampsia in one pregnancy have a substantially increased risk of preeclampsia in subsequent pregnancies. We estimate the recurrence risks of preeclampsia in data from Northern Tanzania.

Methods: A prospective cohort study was designed using 19,811 women who delivered singleton infants at a hospital in Northern Tanzania between 2000 and 2008. A total of 3,909 women were recorded with subsequent deliveries in the hospital with follow up through 2010. Adjusted recurrence risks of preeclampsia were computed using regression models.

Results: The absolute recurrence risk of preeclampsia was 25%, which was 9.2-fold (95% CI: 6.4 - 13.2) compared with the risk for women without prior preeclampsia. When there were signs that the preeclampsia in a previous pregnancy had been serious either because the baby was delivered preterm or had died in the perinatal period, the recurrence risk of preeclampsia was even higher. Women who had preeclampsia had increased risk of a series of adverse pregnancy outcomes in future pregnancies. These include perinatal death (RR= 4.3), a baby with low birth weight (RR= 3.5), or a preterm birth (RR= 2.5). These risks were only partly explained by recurrence of preeclampsia.

Conclusions: Preeclampsia in one pregnancy is a strong predictor for preeclampsia and other adverse pregnancy outcomes in subsequent pregnancies in Tanzania. Women with previous preeclampsia may benefit from close follow-up during their pregnancies.

Show MeSH
Related in: MedlinePlus