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Bacterial viability and physical properties of antibacterially modified experimental dental resin composites.

Rüttermann S, Trellenkamp T, Bergmann N, Beikler T, Ritter H, Janda R - PLoS ONE (2013)

Bottom Line: The materials A to C were not unacceptably influenced by the modifications and achieved the minimum values for FS, WS and SL as requested by EN ISO 4049 and did not differ from ST what was also found for Ra.The antibacterial effect of materials A to C was significantly increased when compared with ST meaning that significantly less vital cells were found.Dental resin composites with small quantities of a novel antibacterially doped delivery system or with an antibacterial monomer provided acceptable physical properties and good antibacterial effectiveness.

View Article: PubMed Central - PubMed

Affiliation: Heinrich-Heine-University, Medical Faculty, Centre of Dentistry, Department of Operative Dentistry, Periodontology and Endodontics, Düsseldorf, Germany.

ABSTRACT

Purpose: To investigate the antibacterial effect and the effect on the material properties of a novel delivery system with Irgasan as active agent and methacrylated polymerizable Irgasan when added to experimental dental resin composites.

Materials and methods: A delivery system based on novel polymeric hollow beads, loaded with Irgasan and methacrylated polymerizable Irgasan as active agents were used to manufacture three commonly formulated experimental resin composites. The non-modified resin was used as standard (ST). Material A contained the delivery system providing 4 % (m/m) Irgasan, material B contained 4 % (m/m) methacrylated Irgasan and material C 8 % (m/m) methacrylated Irgasan. Flexural strength (FS), flexural modulus (FM), water sorption (WS), solubility (SL), surface roughness Ra, polymerization shrinkage, contact angle Θ, total surface free energy γS and its apolar γS (LW), polar γS (AB), Lewis acid γS (+)and base γS (-) term as well as bacterial viability were determined. Significance was p < 0.05.

Results: The materials A to C were not unacceptably influenced by the modifications and achieved the minimum values for FS, WS and SL as requested by EN ISO 4049 and did not differ from ST what was also found for Ra. Only A had lower FM than ST. Θ of A and C was higher and γS (AB) of A and B was lower than of ST. Materials A to C had higher γS (+) than ST. The antibacterial effect of materials A to C was significantly increased when compared with ST meaning that significantly less vital cells were found.

Conclusion: Dental resin composites with small quantities of a novel antibacterially doped delivery system or with an antibacterial monomer provided acceptable physical properties and good antibacterial effectiveness. The sorption material being part of the delivery system can be used as a vehicle for any other active agent.

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Poly-Pore hollow bead sorption material, unloaded (magnification 500 x).
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pone-0079119-g001: Poly-Pore hollow bead sorption material, unloaded (magnification 500 x).

Mentions: Four experimental resin-based restorative materials were prepared (Tables 1 and 2) using a laboratory vacuum planet kneader (Herbst Maschinenfabrik GmbH, Buxtehude, Germany). The standard ST represented a common formulation for resin-based restorative materials. Poly-Pore sorption material loaded with Irgasan (5-chloro-2-(2,4-dichlorophenoxy)phenole) as active agent (Tables 1 and 2, Figure 1) was the delivery system. ST was modified by replacing parts of the glass filler with the delivery system resulting in material A. The matrix of ST was partly replaced by polymerizable Methacryl-Irga (Table 1 and 2, Figure 2) to obtain materials B and C. Flexural strength, flexural modulus, water sorption, solubility and surface roughness Ra were determined. Curing was done with a quartz-tungsten halogen device (Spectrum 800, Dentsply De Trey GmbH, Constance, Germany) performing an irradiance of 931 ± 90 mW cm-2 which was checked periodically with the bluephase meter (Ivoclar Vivadent AG, Schaan, Liechtenstein).


Bacterial viability and physical properties of antibacterially modified experimental dental resin composites.

Rüttermann S, Trellenkamp T, Bergmann N, Beikler T, Ritter H, Janda R - PLoS ONE (2013)

Poly-Pore hollow bead sorption material, unloaded (magnification 500 x).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3815119&req=5

pone-0079119-g001: Poly-Pore hollow bead sorption material, unloaded (magnification 500 x).
Mentions: Four experimental resin-based restorative materials were prepared (Tables 1 and 2) using a laboratory vacuum planet kneader (Herbst Maschinenfabrik GmbH, Buxtehude, Germany). The standard ST represented a common formulation for resin-based restorative materials. Poly-Pore sorption material loaded with Irgasan (5-chloro-2-(2,4-dichlorophenoxy)phenole) as active agent (Tables 1 and 2, Figure 1) was the delivery system. ST was modified by replacing parts of the glass filler with the delivery system resulting in material A. The matrix of ST was partly replaced by polymerizable Methacryl-Irga (Table 1 and 2, Figure 2) to obtain materials B and C. Flexural strength, flexural modulus, water sorption, solubility and surface roughness Ra were determined. Curing was done with a quartz-tungsten halogen device (Spectrum 800, Dentsply De Trey GmbH, Constance, Germany) performing an irradiance of 931 ± 90 mW cm-2 which was checked periodically with the bluephase meter (Ivoclar Vivadent AG, Schaan, Liechtenstein).

Bottom Line: The materials A to C were not unacceptably influenced by the modifications and achieved the minimum values for FS, WS and SL as requested by EN ISO 4049 and did not differ from ST what was also found for Ra.The antibacterial effect of materials A to C was significantly increased when compared with ST meaning that significantly less vital cells were found.Dental resin composites with small quantities of a novel antibacterially doped delivery system or with an antibacterial monomer provided acceptable physical properties and good antibacterial effectiveness.

View Article: PubMed Central - PubMed

Affiliation: Heinrich-Heine-University, Medical Faculty, Centre of Dentistry, Department of Operative Dentistry, Periodontology and Endodontics, Düsseldorf, Germany.

ABSTRACT

Purpose: To investigate the antibacterial effect and the effect on the material properties of a novel delivery system with Irgasan as active agent and methacrylated polymerizable Irgasan when added to experimental dental resin composites.

Materials and methods: A delivery system based on novel polymeric hollow beads, loaded with Irgasan and methacrylated polymerizable Irgasan as active agents were used to manufacture three commonly formulated experimental resin composites. The non-modified resin was used as standard (ST). Material A contained the delivery system providing 4 % (m/m) Irgasan, material B contained 4 % (m/m) methacrylated Irgasan and material C 8 % (m/m) methacrylated Irgasan. Flexural strength (FS), flexural modulus (FM), water sorption (WS), solubility (SL), surface roughness Ra, polymerization shrinkage, contact angle Θ, total surface free energy γS and its apolar γS (LW), polar γS (AB), Lewis acid γS (+)and base γS (-) term as well as bacterial viability were determined. Significance was p < 0.05.

Results: The materials A to C were not unacceptably influenced by the modifications and achieved the minimum values for FS, WS and SL as requested by EN ISO 4049 and did not differ from ST what was also found for Ra. Only A had lower FM than ST. Θ of A and C was higher and γS (AB) of A and B was lower than of ST. Materials A to C had higher γS (+) than ST. The antibacterial effect of materials A to C was significantly increased when compared with ST meaning that significantly less vital cells were found.

Conclusion: Dental resin composites with small quantities of a novel antibacterially doped delivery system or with an antibacterial monomer provided acceptable physical properties and good antibacterial effectiveness. The sorption material being part of the delivery system can be used as a vehicle for any other active agent.

Show MeSH