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Renoprotective effect of the antioxidant curcumin: Recent findings.

Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J - Redox Biol (2013)

Bottom Line: Another recent finding shows that the renoprotective effect of curcumin is associated to preservation of function and redox balance of mitochondria.Taking together, these studies attribute the protective effect of curcumin in the kidney to the induction of the master regulator of antioxidant response nuclear factor erythroid-derived 2 (Nrf2), inhibition of mitochondrial dysfunction, attenuation of inflammatory response, preservation of antioxidant enzymes and prevention of oxidative stress.The information presented in this paper identifies curcumin as a promising renoprotective molecule against renal injury.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Facultad de Química, UNAM, Ciudad Universitaria, 04510 México, DF, Mexico.

ABSTRACT
For years, there have been studies based on the use of natural compounds plant-derived as potential therapeutic agents for various diseases in humans. Curcumin is a phenolic compound extracted from Curcuma longa rhizome commonly used in Asia as a spice, pigment and additive. In traditional medicine of India and China, curcumin is considered as a therapeutic agent used in several foods. Numerous studies have shown that curcumin has broad biological functions particularly antioxidant and antiinflammatory. In fact, it has been established that curcumin is a bifunctional antioxidant; it exerts antioxidant activity in a direct and an indirect way by scavenging reactive oxygen species and inducing an antioxidant response, respectively. The renoprotective effect of curcumin has been evaluated in several experimental models including diabetic nephropathy, chronic renal failure, ischemia and reperfusion and nephrotoxicity induced by compounds such as gentamicin, adriamycin, chloroquine, iron nitrilotriacetate, sodium fluoride, hexavalent chromium and cisplatin. It has been shown recently in a model of chronic renal failure that curcumin exerts a therapeutic effect; in fact it reverts not only systemic alterations but also glomerular hemodynamic changes. Another recent finding shows that the renoprotective effect of curcumin is associated to preservation of function and redox balance of mitochondria. Taking together, these studies attribute the protective effect of curcumin in the kidney to the induction of the master regulator of antioxidant response nuclear factor erythroid-derived 2 (Nrf2), inhibition of mitochondrial dysfunction, attenuation of inflammatory response, preservation of antioxidant enzymes and prevention of oxidative stress. The information presented in this paper identifies curcumin as a promising renoprotective molecule against renal injury.

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Chemical structures and abundance of curcuminoids in turmeric that have terapeutic effects.
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f0005: Chemical structures and abundance of curcuminoids in turmeric that have terapeutic effects.

Mentions: Curcuma contains 60–70% carbohydrate, 8.6% protein, 5–10% fat, 2–7% fiber, 3–5% curcuminoids (50–70% curcumin) and up to 5% essential oils and resins. The curcuminoid content in turmeric may vary between 2 and 9%, depending on geographical conditions [29]. The composition of curcuminoids is approximately 70% curcumin (curcumin I), 17% demethoxycurcumin (curcumin II), 3% bis-demethoxycurcumin (curcumin III) and the rest (10%) is called cyclocurcumin (curcumin IV) [5,8,36] (Fig. 1). However, the last compound has been associated with poor or non-biological activity [61]. The most active component of turmeric is curcumin [67]; Vogel first isolated it in 1815 [29]. Curcumin is an orange–yellow crystalline powder practically insoluble in water. The structure of curcumin (Fig. 1) was first described in 1910 by Lampe and Milobedeska and proved to be diferuloylmethane [29]. Studies indicate that functional groups associated to curcumin chemical structure including bis-α,β−unsaturated β-diketone, two methoxy groups, two phenolic hydroxy groups and two double-conjugated bonds might play an essential role in antiproliferative and anti-inflammatory activities assigned to curcumin [3]. Curcumin has keto-enol tautomers, of which keto form predominates in acid and neutral solutions and enol form in alkaline solutions.


Renoprotective effect of the antioxidant curcumin: Recent findings.

Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J - Redox Biol (2013)

Chemical structures and abundance of curcuminoids in turmeric that have terapeutic effects.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814973&req=5

f0005: Chemical structures and abundance of curcuminoids in turmeric that have terapeutic effects.
Mentions: Curcuma contains 60–70% carbohydrate, 8.6% protein, 5–10% fat, 2–7% fiber, 3–5% curcuminoids (50–70% curcumin) and up to 5% essential oils and resins. The curcuminoid content in turmeric may vary between 2 and 9%, depending on geographical conditions [29]. The composition of curcuminoids is approximately 70% curcumin (curcumin I), 17% demethoxycurcumin (curcumin II), 3% bis-demethoxycurcumin (curcumin III) and the rest (10%) is called cyclocurcumin (curcumin IV) [5,8,36] (Fig. 1). However, the last compound has been associated with poor or non-biological activity [61]. The most active component of turmeric is curcumin [67]; Vogel first isolated it in 1815 [29]. Curcumin is an orange–yellow crystalline powder practically insoluble in water. The structure of curcumin (Fig. 1) was first described in 1910 by Lampe and Milobedeska and proved to be diferuloylmethane [29]. Studies indicate that functional groups associated to curcumin chemical structure including bis-α,β−unsaturated β-diketone, two methoxy groups, two phenolic hydroxy groups and two double-conjugated bonds might play an essential role in antiproliferative and anti-inflammatory activities assigned to curcumin [3]. Curcumin has keto-enol tautomers, of which keto form predominates in acid and neutral solutions and enol form in alkaline solutions.

Bottom Line: Another recent finding shows that the renoprotective effect of curcumin is associated to preservation of function and redox balance of mitochondria.Taking together, these studies attribute the protective effect of curcumin in the kidney to the induction of the master regulator of antioxidant response nuclear factor erythroid-derived 2 (Nrf2), inhibition of mitochondrial dysfunction, attenuation of inflammatory response, preservation of antioxidant enzymes and prevention of oxidative stress.The information presented in this paper identifies curcumin as a promising renoprotective molecule against renal injury.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Facultad de Química, UNAM, Ciudad Universitaria, 04510 México, DF, Mexico.

ABSTRACT
For years, there have been studies based on the use of natural compounds plant-derived as potential therapeutic agents for various diseases in humans. Curcumin is a phenolic compound extracted from Curcuma longa rhizome commonly used in Asia as a spice, pigment and additive. In traditional medicine of India and China, curcumin is considered as a therapeutic agent used in several foods. Numerous studies have shown that curcumin has broad biological functions particularly antioxidant and antiinflammatory. In fact, it has been established that curcumin is a bifunctional antioxidant; it exerts antioxidant activity in a direct and an indirect way by scavenging reactive oxygen species and inducing an antioxidant response, respectively. The renoprotective effect of curcumin has been evaluated in several experimental models including diabetic nephropathy, chronic renal failure, ischemia and reperfusion and nephrotoxicity induced by compounds such as gentamicin, adriamycin, chloroquine, iron nitrilotriacetate, sodium fluoride, hexavalent chromium and cisplatin. It has been shown recently in a model of chronic renal failure that curcumin exerts a therapeutic effect; in fact it reverts not only systemic alterations but also glomerular hemodynamic changes. Another recent finding shows that the renoprotective effect of curcumin is associated to preservation of function and redox balance of mitochondria. Taking together, these studies attribute the protective effect of curcumin in the kidney to the induction of the master regulator of antioxidant response nuclear factor erythroid-derived 2 (Nrf2), inhibition of mitochondrial dysfunction, attenuation of inflammatory response, preservation of antioxidant enzymes and prevention of oxidative stress. The information presented in this paper identifies curcumin as a promising renoprotective molecule against renal injury.

Show MeSH
Related in: MedlinePlus