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An investigation of changes in regional gray matter volume in cardiovascular disease patients, pre and post cardiovascular rehabilitation.

Anazodo UC, Shoemaker JK, Suskin N, St Lawrence KS - Neuroimage Clin (2013)

Bottom Line: This study employed voxel-based morphometry of high resolution structural MRI images to investigate; 1) changes in regional gray matter volume (GMV) in CAD patients compared to age-matched controls, and 2) the effects of a six-month exercise-based cardiovascular rehabilitation program on CAD-related GMV decline.Compared to controls, significant decreases in regional GMV were found in the superior, medial and inferior frontal gyrus; superior and inferior parietal gyrus; middle and superior temporal gyrus and in the posterior cerebellum of CAD patients.Cardiovascular rehabilitation was associated with the recovery of regional GMV in the superior frontal gyrus, superior temporal gyrus and posterior cerebellum of the CAD patients as well as the increase in GMV in the supplementary motor area.

View Article: PubMed Central - PubMed

Affiliation: Lawson Health Research Institute, London, ON, Canada ; Department of Medical Biophysics, Western University, London, ON, Canada ; Laboratory for Brain and Heart Health, School of Kinesiology, Western University, London, ON, Canada.

ABSTRACT
Cognitive function decline secondary to cardiovascular disease has been reported. However, little is known about the impact of coronary artery disease (CAD) on the aging brain macrostructure or whether exercise training, in the context of cardiovascular rehabilitation, can affect brain structure following a coronary event. This study employed voxel-based morphometry of high resolution structural MRI images to investigate; 1) changes in regional gray matter volume (GMV) in CAD patients compared to age-matched controls, and 2) the effects of a six-month exercise-based cardiovascular rehabilitation program on CAD-related GMV decline. Compared to controls, significant decreases in regional GMV were found in the superior, medial and inferior frontal gyrus; superior and inferior parietal gyrus; middle and superior temporal gyrus and in the posterior cerebellum of CAD patients. Cardiovascular rehabilitation was associated with the recovery of regional GMV in the superior frontal gyrus, superior temporal gyrus and posterior cerebellum of the CAD patients as well as the increase in GMV in the supplementary motor area. Total and regional GMV correlated with fitness level, defined by the maximal oxygen consumption (VO2max), at baseline but not after cardiovascular rehabilitation. This study demonstrates that cardiovascular disease can adversely affect age-related decline in GMV; and that these disease-related effects could be mitigated by moderate levels of exercise training as part of cardiovascular rehabilitation.

No MeSH data available.


Related in: MedlinePlus

Differences in GMV between CAD patients and age-matched controls measured at baseline. t-Statistics displayed on a rendered model of a single subject brain. The red blobs on coronal, sagittal and transverse planes indicate areas of decreased GMV in the CAD patient group.
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f0005: Differences in GMV between CAD patients and age-matched controls measured at baseline. t-Statistics displayed on a rendered model of a single subject brain. The red blobs on coronal, sagittal and transverse planes indicate areas of decreased GMV in the CAD patient group.

Mentions: VBM results of regional GMV differences between patients and controls are shown in Fig. 1, and the corresponding MNI coordinates and Talairach anatomical labels are listed in Table 2. In general, the CAD patient group exhibited significantly lower GMV in the frontal lobe, parietal lobe, temporal lobe, and cerebellum. There was a significant difference in total GMV (F = 5.5 (1, 53), p < 0.05) between groups but no statistical difference in total intracranial volume. There were moderate positive associations between VO2max and total GMV (ρ = 0.420(38), p < 0.001), and GMV in the left posterior cerebellum (ρ = 0.616 (38), p < 0.001) and right post central gyrus (ρ = 0.403 (38), p < 0.01). There was no significant gender-by-group interaction, nor was there any correlation between total/regional GMV and MoCA scores or any other clinical parameter measured. Repeating the VBM analysis after removing the data from the 5 patients acquired on the second system had no effect on these results, except to reduce the effect size of the observed regional changes by 5 ± 13%.


An investigation of changes in regional gray matter volume in cardiovascular disease patients, pre and post cardiovascular rehabilitation.

Anazodo UC, Shoemaker JK, Suskin N, St Lawrence KS - Neuroimage Clin (2013)

Differences in GMV between CAD patients and age-matched controls measured at baseline. t-Statistics displayed on a rendered model of a single subject brain. The red blobs on coronal, sagittal and transverse planes indicate areas of decreased GMV in the CAD patient group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814972&req=5

f0005: Differences in GMV between CAD patients and age-matched controls measured at baseline. t-Statistics displayed on a rendered model of a single subject brain. The red blobs on coronal, sagittal and transverse planes indicate areas of decreased GMV in the CAD patient group.
Mentions: VBM results of regional GMV differences between patients and controls are shown in Fig. 1, and the corresponding MNI coordinates and Talairach anatomical labels are listed in Table 2. In general, the CAD patient group exhibited significantly lower GMV in the frontal lobe, parietal lobe, temporal lobe, and cerebellum. There was a significant difference in total GMV (F = 5.5 (1, 53), p < 0.05) between groups but no statistical difference in total intracranial volume. There were moderate positive associations between VO2max and total GMV (ρ = 0.420(38), p < 0.001), and GMV in the left posterior cerebellum (ρ = 0.616 (38), p < 0.001) and right post central gyrus (ρ = 0.403 (38), p < 0.01). There was no significant gender-by-group interaction, nor was there any correlation between total/regional GMV and MoCA scores or any other clinical parameter measured. Repeating the VBM analysis after removing the data from the 5 patients acquired on the second system had no effect on these results, except to reduce the effect size of the observed regional changes by 5 ± 13%.

Bottom Line: This study employed voxel-based morphometry of high resolution structural MRI images to investigate; 1) changes in regional gray matter volume (GMV) in CAD patients compared to age-matched controls, and 2) the effects of a six-month exercise-based cardiovascular rehabilitation program on CAD-related GMV decline.Compared to controls, significant decreases in regional GMV were found in the superior, medial and inferior frontal gyrus; superior and inferior parietal gyrus; middle and superior temporal gyrus and in the posterior cerebellum of CAD patients.Cardiovascular rehabilitation was associated with the recovery of regional GMV in the superior frontal gyrus, superior temporal gyrus and posterior cerebellum of the CAD patients as well as the increase in GMV in the supplementary motor area.

View Article: PubMed Central - PubMed

Affiliation: Lawson Health Research Institute, London, ON, Canada ; Department of Medical Biophysics, Western University, London, ON, Canada ; Laboratory for Brain and Heart Health, School of Kinesiology, Western University, London, ON, Canada.

ABSTRACT
Cognitive function decline secondary to cardiovascular disease has been reported. However, little is known about the impact of coronary artery disease (CAD) on the aging brain macrostructure or whether exercise training, in the context of cardiovascular rehabilitation, can affect brain structure following a coronary event. This study employed voxel-based morphometry of high resolution structural MRI images to investigate; 1) changes in regional gray matter volume (GMV) in CAD patients compared to age-matched controls, and 2) the effects of a six-month exercise-based cardiovascular rehabilitation program on CAD-related GMV decline. Compared to controls, significant decreases in regional GMV were found in the superior, medial and inferior frontal gyrus; superior and inferior parietal gyrus; middle and superior temporal gyrus and in the posterior cerebellum of CAD patients. Cardiovascular rehabilitation was associated with the recovery of regional GMV in the superior frontal gyrus, superior temporal gyrus and posterior cerebellum of the CAD patients as well as the increase in GMV in the supplementary motor area. Total and regional GMV correlated with fitness level, defined by the maximal oxygen consumption (VO2max), at baseline but not after cardiovascular rehabilitation. This study demonstrates that cardiovascular disease can adversely affect age-related decline in GMV; and that these disease-related effects could be mitigated by moderate levels of exercise training as part of cardiovascular rehabilitation.

No MeSH data available.


Related in: MedlinePlus