Limits...
The emerging roles of somatic globins in cardiovascular redox biology and beyond.

Rahaman MM, Straub AC - Redox Biol (2013)

Bottom Line: The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology.This graphical review will provide a comprehensive synopsis of somatic cardiovascular globins focusing on expression, function and redox signaling - an emerging area in both physiology and disease.

View Article: PubMed Central - PubMed

Affiliation: Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15216, USA.

ABSTRACT
The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology. This graphical review will provide a comprehensive synopsis of somatic cardiovascular globins focusing on expression, function and redox signaling - an emerging area in both physiology and disease.

Show MeSH
Known somatic cell types that express hemoglobin, the identified chains, and functions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3814953&req=5

f0020: Known somatic cell types that express hemoglobin, the identified chains, and functions.

Mentions: One of the most remarkable functions of Hb α in the resistance arterial endothelium is its capacity to deactivate NO via the Hb oxidation state [7]. During agonist-induced stimulation with either acetylcholine or phenylephrine, it was shown that met-Hb α permits NO signaling to smooth muscle through a slow, weak interaction with heme Fe (3.3×103 M−1 s−1), whereas oxy-Hb α inhibited signaling through the fast, irreversible dioxygenation reaction (2.4×107 M−1 s−1). It was discovered that met-Hb reductase or cytochrome B5 reductase 3 (CytB5R3) was critical for the redox cycling from met-Hb α to oxy-Hb α. This paradigm highlights an emerging, yet critically important role for Hb redox state, whereby NO signaling can be switched “on-or-off” (Fig. 3). This evidence may provide a plausible explanation for understanding the Hb-NO paradox in the physiology of blood pressure and flow control. Intriguingly, this paradigm of Hb-NO regulation in somatic cells may go beyond arterial endothelial cells. In fact, many other cell types including Type II alveolar epithelial cells [29–31], renal mesangial cells [32], hepatocytes [33], macrophages [34], neurons [35–39] and endometrial cells [40] express Hb (Fig. 4).


The emerging roles of somatic globins in cardiovascular redox biology and beyond.

Rahaman MM, Straub AC - Redox Biol (2013)

Known somatic cell types that express hemoglobin, the identified chains, and functions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814953&req=5

f0020: Known somatic cell types that express hemoglobin, the identified chains, and functions.
Mentions: One of the most remarkable functions of Hb α in the resistance arterial endothelium is its capacity to deactivate NO via the Hb oxidation state [7]. During agonist-induced stimulation with either acetylcholine or phenylephrine, it was shown that met-Hb α permits NO signaling to smooth muscle through a slow, weak interaction with heme Fe (3.3×103 M−1 s−1), whereas oxy-Hb α inhibited signaling through the fast, irreversible dioxygenation reaction (2.4×107 M−1 s−1). It was discovered that met-Hb reductase or cytochrome B5 reductase 3 (CytB5R3) was critical for the redox cycling from met-Hb α to oxy-Hb α. This paradigm highlights an emerging, yet critically important role for Hb redox state, whereby NO signaling can be switched “on-or-off” (Fig. 3). This evidence may provide a plausible explanation for understanding the Hb-NO paradox in the physiology of blood pressure and flow control. Intriguingly, this paradigm of Hb-NO regulation in somatic cells may go beyond arterial endothelial cells. In fact, many other cell types including Type II alveolar epithelial cells [29–31], renal mesangial cells [32], hepatocytes [33], macrophages [34], neurons [35–39] and endometrial cells [40] express Hb (Fig. 4).

Bottom Line: The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology.This graphical review will provide a comprehensive synopsis of somatic cardiovascular globins focusing on expression, function and redox signaling - an emerging area in both physiology and disease.

View Article: PubMed Central - PubMed

Affiliation: Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15216, USA.

ABSTRACT
The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology. This graphical review will provide a comprehensive synopsis of somatic cardiovascular globins focusing on expression, function and redox signaling - an emerging area in both physiology and disease.

Show MeSH