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The emerging roles of somatic globins in cardiovascular redox biology and beyond.

Rahaman MM, Straub AC - Redox Biol (2013)

Bottom Line: The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology.This graphical review will provide a comprehensive synopsis of somatic cardiovascular globins focusing on expression, function and redox signaling - an emerging area in both physiology and disease.

View Article: PubMed Central - PubMed

Affiliation: Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15216, USA.

ABSTRACT
The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology. This graphical review will provide a comprehensive synopsis of somatic cardiovascular globins focusing on expression, function and redox signaling - an emerging area in both physiology and disease.

Show MeSH
Cell type-specific expression of hemoglobin, myoglobin, cytoglobin and neuroglobin along the vascular tree.
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f0010: Cell type-specific expression of hemoglobin, myoglobin, cytoglobin and neuroglobin along the vascular tree.

Mentions: Within the cardiovascular system, cell-type expression and localization of each globin is variable. Hb, composed of α and β chains, was traditionally known for exclusive expression in red blood cells, although a recent reports have dismissed this perception through the discovery of Hb α expression in microvascular endothelial cells [7,8]. Mb expression is abundant in cardiomyocytes but is found to a lesser extent in vascular smooth muscle cells [9,10]. Cgb chiefly resides in cardiomyocytes, advential fibroblasts and vascular smooth muscle cells [11,12], whereas sympathetic nerves express Ngb [13]. Remarkably, globin expression is not homogeneous through the vascular tree. This is particularly true for Hb and Mb. Hb α expression is mainly found in resistance arteries and arterioles [7], whereas Mb is primarily expressed in conduit arteries but absent in small arteries [7,10] (Fig. 2). The explanation for globin expression inconsistency throughout the vascular tree remains unknown. These disparities likely reflect specific transcriptional, post-transcriptional, and translational events for each globin as it relates to their precise role(s) within the vascular cell itself.


The emerging roles of somatic globins in cardiovascular redox biology and beyond.

Rahaman MM, Straub AC - Redox Biol (2013)

Cell type-specific expression of hemoglobin, myoglobin, cytoglobin and neuroglobin along the vascular tree.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814953&req=5

f0010: Cell type-specific expression of hemoglobin, myoglobin, cytoglobin and neuroglobin along the vascular tree.
Mentions: Within the cardiovascular system, cell-type expression and localization of each globin is variable. Hb, composed of α and β chains, was traditionally known for exclusive expression in red blood cells, although a recent reports have dismissed this perception through the discovery of Hb α expression in microvascular endothelial cells [7,8]. Mb expression is abundant in cardiomyocytes but is found to a lesser extent in vascular smooth muscle cells [9,10]. Cgb chiefly resides in cardiomyocytes, advential fibroblasts and vascular smooth muscle cells [11,12], whereas sympathetic nerves express Ngb [13]. Remarkably, globin expression is not homogeneous through the vascular tree. This is particularly true for Hb and Mb. Hb α expression is mainly found in resistance arteries and arterioles [7], whereas Mb is primarily expressed in conduit arteries but absent in small arteries [7,10] (Fig. 2). The explanation for globin expression inconsistency throughout the vascular tree remains unknown. These disparities likely reflect specific transcriptional, post-transcriptional, and translational events for each globin as it relates to their precise role(s) within the vascular cell itself.

Bottom Line: The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology.This graphical review will provide a comprehensive synopsis of somatic cardiovascular globins focusing on expression, function and redox signaling - an emerging area in both physiology and disease.

View Article: PubMed Central - PubMed

Affiliation: Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15216, USA.

ABSTRACT
The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology. This graphical review will provide a comprehensive synopsis of somatic cardiovascular globins focusing on expression, function and redox signaling - an emerging area in both physiology and disease.

Show MeSH