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A comparison of the effect of pretreatment with intravenous dexamethasone, intravenous ketamine, and their combination, for suppression of remifentanil-induced cough: A randomized, double-blind, placebo-controlled clinical trial.

Honarmand A, Safavi M, Khalighinejad F - Adv Biomed Res (2013)

Bottom Line: The incidence of RIC was significantly lower in Group KD compared to Group K, Group D, and Group S (3.3 vs. 20%, 20%, and 46.7%, respectively, P < 0.05).The severity of RIC was significantly lower in Group KD compared to Group K, Group D, and Group S (P < 0.05).We found that pretreatment with 10 mg ketamine in combination with 10 mg dexamethasone five minutes prior to the injection of remifentanil could significantly reduce the incidence of RIC, and it was better than using each drug singly.

View Article: PubMed Central - PubMed

Affiliation: Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: The injection of remifentanil can cause cough during induction of anesthesia. This study was designed to examine the efficacy of ketamine, dexamethasone, and their combination on remifentanil-induced cough (RIC).

Materials and methods: ONE HUNDRED AND TWENTY PATIENTS SCHEDULED FOR ELECTIVE SURGERY WERE RANDOMLY ASSIGNED INTO FOUR GROUPS: Group K received 10 mg ketamine; Group D received 10 mg dexamethasone; Group KD received 10 mg ketamine in combination with dexamethasone; and Group S received saline in a similar volume, five minutes prior to the injection of remifentanil. The incidence and severity of the cough was recorded in each person.

Results: The incidence of RIC was significantly lower in Group KD compared to Group K, Group D, and Group S (3.3 vs. 20%, 20%, and 46.7%, respectively, P < 0.05). The severity of RIC was significantly lower in Group KD compared to Group K, Group D, and Group S (P < 0.05). There was no significant difference between Group K and Group D in this regard (P > 0.05). There was no significant difference in the onset time of coughing among the four groups (19.8 ± 1.3, 20.8 ± 0.9, 19.0 ± 1.1, and 19.9 ± 2.2 in Group K, Group D, Group KD, and Group S, respectively, P > 0.05).

Conclusion: We found that pretreatment with 10 mg ketamine in combination with 10 mg dexamethasone five minutes prior to the injection of remifentanil could significantly reduce the incidence of RIC, and it was better than using each drug singly.

No MeSH data available.


Related in: MedlinePlus

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Figure 1: Consort flow diagram

Mentions: In this study, a total of 129 consecutive patients were evaluated during one year with ASA I and II, who were candidates for elective surgery, under general anesthesia. Out of these, nine patients were excluded from the study. Subsequently, nine patients in four groups were unable to cooperate and were, therefore, excluded from the study [Figure 1]. Therefore, 120 patients were included in the study and received study medication after randomization.


A comparison of the effect of pretreatment with intravenous dexamethasone, intravenous ketamine, and their combination, for suppression of remifentanil-induced cough: A randomized, double-blind, placebo-controlled clinical trial.

Honarmand A, Safavi M, Khalighinejad F - Adv Biomed Res (2013)

Consort flow diagram
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814903&req=5

Figure 1: Consort flow diagram
Mentions: In this study, a total of 129 consecutive patients were evaluated during one year with ASA I and II, who were candidates for elective surgery, under general anesthesia. Out of these, nine patients were excluded from the study. Subsequently, nine patients in four groups were unable to cooperate and were, therefore, excluded from the study [Figure 1]. Therefore, 120 patients were included in the study and received study medication after randomization.

Bottom Line: The incidence of RIC was significantly lower in Group KD compared to Group K, Group D, and Group S (3.3 vs. 20%, 20%, and 46.7%, respectively, P < 0.05).The severity of RIC was significantly lower in Group KD compared to Group K, Group D, and Group S (P < 0.05).We found that pretreatment with 10 mg ketamine in combination with 10 mg dexamethasone five minutes prior to the injection of remifentanil could significantly reduce the incidence of RIC, and it was better than using each drug singly.

View Article: PubMed Central - PubMed

Affiliation: Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: The injection of remifentanil can cause cough during induction of anesthesia. This study was designed to examine the efficacy of ketamine, dexamethasone, and their combination on remifentanil-induced cough (RIC).

Materials and methods: ONE HUNDRED AND TWENTY PATIENTS SCHEDULED FOR ELECTIVE SURGERY WERE RANDOMLY ASSIGNED INTO FOUR GROUPS: Group K received 10 mg ketamine; Group D received 10 mg dexamethasone; Group KD received 10 mg ketamine in combination with dexamethasone; and Group S received saline in a similar volume, five minutes prior to the injection of remifentanil. The incidence and severity of the cough was recorded in each person.

Results: The incidence of RIC was significantly lower in Group KD compared to Group K, Group D, and Group S (3.3 vs. 20%, 20%, and 46.7%, respectively, P < 0.05). The severity of RIC was significantly lower in Group KD compared to Group K, Group D, and Group S (P < 0.05). There was no significant difference between Group K and Group D in this regard (P > 0.05). There was no significant difference in the onset time of coughing among the four groups (19.8 ± 1.3, 20.8 ± 0.9, 19.0 ± 1.1, and 19.9 ± 2.2 in Group K, Group D, Group KD, and Group S, respectively, P > 0.05).

Conclusion: We found that pretreatment with 10 mg ketamine in combination with 10 mg dexamethasone five minutes prior to the injection of remifentanil could significantly reduce the incidence of RIC, and it was better than using each drug singly.

No MeSH data available.


Related in: MedlinePlus