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Hypertriglyceridemia is frequent in endometrial cancer survivors.

Hirasawa A, Makita K, Akahane T, Yokota M, Yamagami W, Banno K, Susumu N, Aoki D - Jpn. J. Clin. Oncol. (2013)

Bottom Line: Premenopausal bilateral salpingo-oophorectomy may cause adverse events, including dyslipidemia.We divided the patients into two categories according to whether they had a premenopausal or postmenopausal bilateral oophorectomy.Serum lipid levels were measured and statistically analyzed.

View Article: PubMed Central - PubMed

Affiliation: *Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan. hir-aki@z8.keio.jp.

ABSTRACT

Objective: Previous studies have reported an association between endometrial cancer and the risk of metabolic syndrome; however, the pattern of endometrial cancer-associated dyslipidemia is not well understood. The standard therapy for endometrial cancer is total abdominal hysterectomy and bilateral salpingo-oophorectomy. Premenopausal bilateral salpingo-oophorectomy may cause adverse events, including dyslipidemia. Gynecologists have to care dyslipidemia in endometrial cancer survivors at cancer follow-up clinic.

Methods: This study included 693 patients who had undergone bilateral salpingo-oophorectomy, and included 412 women with incident endometrial cancer and 281 controls. We divided the patients into two categories according to whether they had a premenopausal or postmenopausal bilateral oophorectomy. Serum lipid levels were measured and statistically analyzed.

Results: Hypertriglyceridemia was statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy both before and after menopause than in the corresponding non-endometrial cancer controls. High levels of low-density lipoprotein cholesterol and a high low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio were statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy before menopause than in non-endometrial cancer controls.

Conclusions: Our report highlights the importance of the relationship between endometrial cancer and lipid metabolism, which may aid in preventing cerebrovascular or cardiovascular diseases due to dyslipidemia and improving the quality of life in endometrial cancer survivors.

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Related in: MedlinePlus

Mann–Whitney U test for low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and the LDL-C/high-density lipoprotein cholesterol (HDL-C) ratio in endometrial cancer and non-endometrial cancer groups.
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HYT125F1: Mann–Whitney U test for low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and the LDL-C/high-density lipoprotein cholesterol (HDL-C) ratio in endometrial cancer and non-endometrial cancer groups.

Mentions: Differences between the serum lipid levels of each group were analyzed using the Mann–Whitney U test (Fig. 1). TG levels were significantly higher in all EC groups (P < 0.0001). LDL-C levels (P = 0.0071) and the LDL-C/HDL-C ratio (P = 0.0020) were significantly higher in the EC patients of the premenopausal BSO group.Figure 1.


Hypertriglyceridemia is frequent in endometrial cancer survivors.

Hirasawa A, Makita K, Akahane T, Yokota M, Yamagami W, Banno K, Susumu N, Aoki D - Jpn. J. Clin. Oncol. (2013)

Mann–Whitney U test for low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and the LDL-C/high-density lipoprotein cholesterol (HDL-C) ratio in endometrial cancer and non-endometrial cancer groups.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814898&req=5

HYT125F1: Mann–Whitney U test for low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and the LDL-C/high-density lipoprotein cholesterol (HDL-C) ratio in endometrial cancer and non-endometrial cancer groups.
Mentions: Differences between the serum lipid levels of each group were analyzed using the Mann–Whitney U test (Fig. 1). TG levels were significantly higher in all EC groups (P < 0.0001). LDL-C levels (P = 0.0071) and the LDL-C/HDL-C ratio (P = 0.0020) were significantly higher in the EC patients of the premenopausal BSO group.Figure 1.

Bottom Line: Premenopausal bilateral salpingo-oophorectomy may cause adverse events, including dyslipidemia.We divided the patients into two categories according to whether they had a premenopausal or postmenopausal bilateral oophorectomy.Serum lipid levels were measured and statistically analyzed.

View Article: PubMed Central - PubMed

Affiliation: *Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan. hir-aki@z8.keio.jp.

ABSTRACT

Objective: Previous studies have reported an association between endometrial cancer and the risk of metabolic syndrome; however, the pattern of endometrial cancer-associated dyslipidemia is not well understood. The standard therapy for endometrial cancer is total abdominal hysterectomy and bilateral salpingo-oophorectomy. Premenopausal bilateral salpingo-oophorectomy may cause adverse events, including dyslipidemia. Gynecologists have to care dyslipidemia in endometrial cancer survivors at cancer follow-up clinic.

Methods: This study included 693 patients who had undergone bilateral salpingo-oophorectomy, and included 412 women with incident endometrial cancer and 281 controls. We divided the patients into two categories according to whether they had a premenopausal or postmenopausal bilateral oophorectomy. Serum lipid levels were measured and statistically analyzed.

Results: Hypertriglyceridemia was statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy both before and after menopause than in the corresponding non-endometrial cancer controls. High levels of low-density lipoprotein cholesterol and a high low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio were statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy before menopause than in non-endometrial cancer controls.

Conclusions: Our report highlights the importance of the relationship between endometrial cancer and lipid metabolism, which may aid in preventing cerebrovascular or cardiovascular diseases due to dyslipidemia and improving the quality of life in endometrial cancer survivors.

Show MeSH
Related in: MedlinePlus