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Lithium carbonate inducing disorders in three parameters of rat sperm.

Toghyani S, Dashti GR, Roudbari NH, Rouzbehani S, Monajemi R - Adv Biomed Res (2013)

Bottom Line: Lithium has a significant impact in reducing the symptoms of bipolar mania but in long periods of use with therapeutic doses can cause several disorders in various organs including the reproductive system.At the end of this period, sperm cells isolated from the cauda epididymis were counted, motility was estimated, and stained with smear papanicolaou stain.Lithium alters intracellular signaling pathways such as inositol phosphate metabolic cycle and cyclic adenosine mono phosphate (cAMP) system and adenosine triphosphate (ATP) synthesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Islamic Azad University, Tehran Science and Research University, Isfahan, Iran.

ABSTRACT

Background: Lithium has a significant impact in reducing the symptoms of bipolar mania but in long periods of use with therapeutic doses can cause several disorders in various organs including the reproductive system. In this study, the effect of lithium on the sperm concentration and motility and forms of abnormal cells has been examined.

Materials and methods: Male Wistar rats under the 48-day treatment with lithium carbonate at doses of 10, 20, and 30 mg/kg bw/day were kept in standard conditions. At the end of this period, sperm cells isolated from the cauda epididymis were counted, motility was estimated, and stained with smear papanicolaou stain.

Results: In lithium-treated groups, the rate of spermatogenesis and sperm quality were reduced and was seen in a dose-dependent manner.

Discussion: Lithium alters intracellular signaling pathways such as inositol phosphate metabolic cycle and cyclic adenosine mono phosphate (cAMP) system and adenosine triphosphate (ATP) synthesis. It also interferes in the division of sex cells to produce mature sperm and showed changes in the sperm cell membrane, function, and structure.

No MeSH data available.


Related in: MedlinePlus

Percentage of sperm cell motility in groups receiving lithium shows a dose-dependent reduction
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Figure 1: Percentage of sperm cell motility in groups receiving lithium shows a dose-dependent reduction

Mentions: Finally, the results of cell count were statistically analyzed by one-way ANOVA and Duncan post hoc tests using SPSS software and are shown in Table 1 and Figures 1–3.


Lithium carbonate inducing disorders in three parameters of rat sperm.

Toghyani S, Dashti GR, Roudbari NH, Rouzbehani S, Monajemi R - Adv Biomed Res (2013)

Percentage of sperm cell motility in groups receiving lithium shows a dose-dependent reduction
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814897&req=5

Figure 1: Percentage of sperm cell motility in groups receiving lithium shows a dose-dependent reduction
Mentions: Finally, the results of cell count were statistically analyzed by one-way ANOVA and Duncan post hoc tests using SPSS software and are shown in Table 1 and Figures 1–3.

Bottom Line: Lithium has a significant impact in reducing the symptoms of bipolar mania but in long periods of use with therapeutic doses can cause several disorders in various organs including the reproductive system.At the end of this period, sperm cells isolated from the cauda epididymis were counted, motility was estimated, and stained with smear papanicolaou stain.Lithium alters intracellular signaling pathways such as inositol phosphate metabolic cycle and cyclic adenosine mono phosphate (cAMP) system and adenosine triphosphate (ATP) synthesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Islamic Azad University, Tehran Science and Research University, Isfahan, Iran.

ABSTRACT

Background: Lithium has a significant impact in reducing the symptoms of bipolar mania but in long periods of use with therapeutic doses can cause several disorders in various organs including the reproductive system. In this study, the effect of lithium on the sperm concentration and motility and forms of abnormal cells has been examined.

Materials and methods: Male Wistar rats under the 48-day treatment with lithium carbonate at doses of 10, 20, and 30 mg/kg bw/day were kept in standard conditions. At the end of this period, sperm cells isolated from the cauda epididymis were counted, motility was estimated, and stained with smear papanicolaou stain.

Results: In lithium-treated groups, the rate of spermatogenesis and sperm quality were reduced and was seen in a dose-dependent manner.

Discussion: Lithium alters intracellular signaling pathways such as inositol phosphate metabolic cycle and cyclic adenosine mono phosphate (cAMP) system and adenosine triphosphate (ATP) synthesis. It also interferes in the division of sex cells to produce mature sperm and showed changes in the sperm cell membrane, function, and structure.

No MeSH data available.


Related in: MedlinePlus