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Micro Machining of Injection Mold Inserts for Fluidic Channel of Polymeric Biochips

View Article: PubMed Central

ABSTRACT

Recently, the polymeric micro-fluidic biochip, often called LOC (lab-on-a-chip), has been focused as a cheap, rapid and simplified method to replace the existing biochemical laboratory works. It becomes possible to form miniaturized lab functionalities on a chip with the development of MEMS technologies. The micro-fluidic chips contain many micro-channels for the flow of sample and reagents, mixing, and detection tasks. Typical substrate materials for the chip are glass and polymers. Typical techniques for microfluidic chip fabrication are utilizing various micro pattern forming methods, such as wet-etching, micro-contact printing, and hot-embossing, micro injection molding, LIGA, and micro powder blasting processes, etc. In this study, to establish the basis of the micro pattern fabrication and mass production of polymeric micro-fluidic chips using injection molding process, micro machining method was applied to form micro-channels on the LOC molds. In the research, a series of machining experiments using micro end-mills were performed to determine optimum machining conditions to improve surface roughness and shape accuracy of designed simplified micro-channels. Obtained conditions were used to machine required mold inserts for micro-channels using micro end-mills. Test injection processes using machined molds and COC polymer were performed, and then the results were investigated.

No MeSH data available.


Manufactured core and injection mold.
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f9-sensors-07-01643: Manufactured core and injection mold.

Mentions: Based on the previous experimental results, the optimum conditions for core machining to form micro channel were determined as shown in Table 1. SKD11 was used for inject pin and guide bush manufacture; and NAK80 was used for mold cavity and cores for micro channel forming. Figure 9(a) shows the mirror-finished bottom plate core for micro-channel machining. Figure 9(b) and (c) show the machined core, and (d) shows the assembled mold set for the test injection experiments. As shown in figure, 4 cavities are assembled in a mold set.


Micro Machining of Injection Mold Inserts for Fluidic Channel of Polymeric Biochips
Manufactured core and injection mold.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814873&req=5

f9-sensors-07-01643: Manufactured core and injection mold.
Mentions: Based on the previous experimental results, the optimum conditions for core machining to form micro channel were determined as shown in Table 1. SKD11 was used for inject pin and guide bush manufacture; and NAK80 was used for mold cavity and cores for micro channel forming. Figure 9(a) shows the mirror-finished bottom plate core for micro-channel machining. Figure 9(b) and (c) show the machined core, and (d) shows the assembled mold set for the test injection experiments. As shown in figure, 4 cavities are assembled in a mold set.

View Article: PubMed Central

ABSTRACT

Recently, the polymeric micro-fluidic biochip, often called LOC (lab-on-a-chip), has been focused as a cheap, rapid and simplified method to replace the existing biochemical laboratory works. It becomes possible to form miniaturized lab functionalities on a chip with the development of MEMS technologies. The micro-fluidic chips contain many micro-channels for the flow of sample and reagents, mixing, and detection tasks. Typical substrate materials for the chip are glass and polymers. Typical techniques for microfluidic chip fabrication are utilizing various micro pattern forming methods, such as wet-etching, micro-contact printing, and hot-embossing, micro injection molding, LIGA, and micro powder blasting processes, etc. In this study, to establish the basis of the micro pattern fabrication and mass production of polymeric micro-fluidic chips using injection molding process, micro machining method was applied to form micro-channels on the LOC molds. In the research, a series of machining experiments using micro end-mills were performed to determine optimum machining conditions to improve surface roughness and shape accuracy of designed simplified micro-channels. Obtained conditions were used to machine required mold inserts for micro-channels using micro end-mills. Test injection processes using machined molds and COC polymer were performed, and then the results were investigated.

No MeSH data available.