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Development of a Molecularly Imprinted Biomimetic Electrode

View Article: PubMed Central

ABSTRACT

The technique of molecular imprinting produces artificial receptor sites in a polymer that can be used in a biomimetic sensor. This research extends previous studies of a molecularly imprinted polymer (MIP) biomimetic sensor for the small drug theophylline. The presence of theophylline in the biomimetic sensor was monitored by analyzing the peak currents from cyclic voltammetry experiments. The functional working range of the MIP modified electrode was 2 - 4 mM theophylline. The concentration of theophylline that resulted in the best signal was 3 mM. The MIP sensor showed no response to the structurally related molecule caffeine, and therefore was selective to the target analyte theophylline. This research will provide the foundation for future studies that will result in durable biomimetic sensors that can offer a viable alternative to current sensors.

No MeSH data available.


Comparison of the ratio of maximum currents of MIP-ITO sensor to B-ITO at various analyte concentrations.
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f7-sensors-07-01630: Comparison of the ratio of maximum currents of MIP-ITO sensor to B-ITO at various analyte concentrations.

Mentions: The ratio of the maximum and minimum peak currents for 1, 2, 3, and 4 mM theophylline are shown in Figures 7 and 8, respectively. The ratio refers to the peak current on the curve of the selected concentration (1, 2, 3, or 4 mM Thy) divided by the peak current on the baseline curve without theophylline (no Thy). The standard deviation of three samples is shown for both the MIP-ITO and B-ITO sensors at each concentration. The resulting P-values using t-test are also shown in the figures at each concentration.


Development of a Molecularly Imprinted Biomimetic Electrode
Comparison of the ratio of maximum currents of MIP-ITO sensor to B-ITO at various analyte concentrations.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814872&req=5

f7-sensors-07-01630: Comparison of the ratio of maximum currents of MIP-ITO sensor to B-ITO at various analyte concentrations.
Mentions: The ratio of the maximum and minimum peak currents for 1, 2, 3, and 4 mM theophylline are shown in Figures 7 and 8, respectively. The ratio refers to the peak current on the curve of the selected concentration (1, 2, 3, or 4 mM Thy) divided by the peak current on the baseline curve without theophylline (no Thy). The standard deviation of three samples is shown for both the MIP-ITO and B-ITO sensors at each concentration. The resulting P-values using t-test are also shown in the figures at each concentration.

View Article: PubMed Central

ABSTRACT

The technique of molecular imprinting produces artificial receptor sites in a polymer that can be used in a biomimetic sensor. This research extends previous studies of a molecularly imprinted polymer (MIP) biomimetic sensor for the small drug theophylline. The presence of theophylline in the biomimetic sensor was monitored by analyzing the peak currents from cyclic voltammetry experiments. The functional working range of the MIP modified electrode was 2 - 4 mM theophylline. The concentration of theophylline that resulted in the best signal was 3 mM. The MIP sensor showed no response to the structurally related molecule caffeine, and therefore was selective to the target analyte theophylline. This research will provide the foundation for future studies that will result in durable biomimetic sensors that can offer a viable alternative to current sensors.

No MeSH data available.