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Can cytomorphology of granulomas distinguish sarcoidosis from tuberculosis? Retrospective study of endobronchial ultrasound guided transbronchial needle aspirate of 49 granulomatous lymph nodes.

Kaur G, Dhamija A, Augustine J, Bakshi P, Verma K - Cytojournal (2013)

Bottom Line: Based on cytologic features two cytologic categories were enunciated and the results were correlated with microbiologic studies and/follow-up of minimum of 6 months.The cytologic categories did not correlate with the final clinical outcome of patients.The novel non-invasive techniques of mediastinal sampling though help in confirming granulomatous pathology, distinction between these entities and treatment decisions still depend upon correlating cytologic, microbiologic, clinical and radiological data in a large number of cases in tubercular endemic regions.

View Article: PubMed Central - HTML - PubMed

Affiliation: Address: Department of Cytopathology, Sir Gangaram Hospital, New Delhi, India.

ABSTRACT

Background: The differential diagnosis of tuberculosis (TB) and sarcoidosis on fine needle aspiration material is very challenging in tubercular endemic regions. We carried out a pilot study to explore cytomorphologic features of granulomas which could help in differentiation between sarcoidosis and TB. Final diagnoses in these patients were based on clinical, microbiologic and follow-up studies.

Materials and methods: Endobronchial ultrasound guided transbronchial needle aspiration smears of 49 consecutive patients with a final cytologic diagnosis of granulomatous lymphadenitis were reviewed. Based on cytologic features two cytologic categories were enunciated and the results were correlated with microbiologic studies and/follow-up of minimum of 6 months.

Results: The cytologic categories did not correlate with the final clinical outcome of patients.

Conclusions: Different patterns of granulomas observed in cytology smears do not help distinguish TB from sarcoidosis. The novel non-invasive techniques of mediastinal sampling though help in confirming granulomatous pathology, distinction between these entities and treatment decisions still depend upon correlating cytologic, microbiologic, clinical and radiological data in a large number of cases in tubercular endemic regions.

No MeSH data available.


Related in: MedlinePlus

Small granulomas made of few epithelioid cells. The epithelioid cells are well spaced out
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Figure 1: Small granulomas made of few epithelioid cells. The epithelioid cells are well spaced out

Mentions: NCG I – The number of granulomas was less and the size was small. They were made of few epithelioid cells that were well spaced out. The epithelioid cells appeared to be falling away from margins of granulomas [Figure 1].


Can cytomorphology of granulomas distinguish sarcoidosis from tuberculosis? Retrospective study of endobronchial ultrasound guided transbronchial needle aspirate of 49 granulomatous lymph nodes.

Kaur G, Dhamija A, Augustine J, Bakshi P, Verma K - Cytojournal (2013)

Small granulomas made of few epithelioid cells. The epithelioid cells are well spaced out
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814850&req=5

Figure 1: Small granulomas made of few epithelioid cells. The epithelioid cells are well spaced out
Mentions: NCG I – The number of granulomas was less and the size was small. They were made of few epithelioid cells that were well spaced out. The epithelioid cells appeared to be falling away from margins of granulomas [Figure 1].

Bottom Line: Based on cytologic features two cytologic categories were enunciated and the results were correlated with microbiologic studies and/follow-up of minimum of 6 months.The cytologic categories did not correlate with the final clinical outcome of patients.The novel non-invasive techniques of mediastinal sampling though help in confirming granulomatous pathology, distinction between these entities and treatment decisions still depend upon correlating cytologic, microbiologic, clinical and radiological data in a large number of cases in tubercular endemic regions.

View Article: PubMed Central - HTML - PubMed

Affiliation: Address: Department of Cytopathology, Sir Gangaram Hospital, New Delhi, India.

ABSTRACT

Background: The differential diagnosis of tuberculosis (TB) and sarcoidosis on fine needle aspiration material is very challenging in tubercular endemic regions. We carried out a pilot study to explore cytomorphologic features of granulomas which could help in differentiation between sarcoidosis and TB. Final diagnoses in these patients were based on clinical, microbiologic and follow-up studies.

Materials and methods: Endobronchial ultrasound guided transbronchial needle aspiration smears of 49 consecutive patients with a final cytologic diagnosis of granulomatous lymphadenitis were reviewed. Based on cytologic features two cytologic categories were enunciated and the results were correlated with microbiologic studies and/follow-up of minimum of 6 months.

Results: The cytologic categories did not correlate with the final clinical outcome of patients.

Conclusions: Different patterns of granulomas observed in cytology smears do not help distinguish TB from sarcoidosis. The novel non-invasive techniques of mediastinal sampling though help in confirming granulomatous pathology, distinction between these entities and treatment decisions still depend upon correlating cytologic, microbiologic, clinical and radiological data in a large number of cases in tubercular endemic regions.

No MeSH data available.


Related in: MedlinePlus