Limits...
Photodecomposition and phototoxicity of natural retinoids.

Tolleson WH, Cherng SH, Xia Q, Boudreau M, Yin JJ, Wamer WG, Howard PC, Yu H, Fu PP - Int J Environ Res Public Health (2005)

Bottom Line: Sunlight is a known human carcinogen.Many cosmetics contain retinoid-based compounds, such as retinyl palmitate (RP), either to protect the skin or to stimulate skin responses that will correct skin damaged by sunlight.This paper reports the update information and our experimental results on photostability, photoreactions, and phototoxicity of the natural retinoids including retinol (ROH), retinal, retinoid acid (RA), retinyl acetate, and RP (Figure 1).

View Article: PubMed Central - PubMed

Affiliation: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.

ABSTRACT
Sunlight is a known human carcinogen. Many cosmetics contain retinoid-based compounds, such as retinyl palmitate (RP), either to protect the skin or to stimulate skin responses that will correct skin damaged by sunlight. However, little is known about the photodecomposition of some retinoids and the toxicity of these retinoids and their sunlight-induced photodecomposition products on skin. Thus, studies are required to test whether topical application of retinoids enhances the phototoxicity and photocarcinogenicity of sunlight and UV light. Mechanistic studies are needed to provide insight into the disposition of retinoids in vitro and on the skin, and to test thoroughly whether genotoxic damage by UV-induced radicals may participate in any toxicity of topically applied retinoids in the presence of UV light. This paper reports the update information and our experimental results on photostability, photoreactions, and phototoxicity of the natural retinoids including retinol (ROH), retinal, retinoid acid (RA), retinyl acetate, and RP (Figure 1).

Show MeSH

Related in: MedlinePlus

Penetration of skin and eye by solar radiation. (A) Diagram of skin. (B) Diagram of eye.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3814709&req=5

f9-ijerph-02-00147: Penetration of skin and eye by solar radiation. (A) Diagram of skin. (B) Diagram of eye.

Mentions: The depth to which solar radiation penetrates tissues, and thereby induces adverse biological effects, depends strongly on its wavelength. In addition, the spectral transmission/absorption characteristics of solar-exposed tissues (Figure 9) influence penetration of light. These and other factors result in the generation of action spectra for photoinjuries to skin and eye components. The action spectra for each photohazard category (Figure 10) were applied to the most sensitive components of the eye or skin to arrive at threshold limit values (TLV) for ocular and cutaneous exposures to monochromatic and broadband light sources. The TLV were established in 1996 by the American Conference of Governmental Industrial Hygenists (ACGIH) (30).


Photodecomposition and phototoxicity of natural retinoids.

Tolleson WH, Cherng SH, Xia Q, Boudreau M, Yin JJ, Wamer WG, Howard PC, Yu H, Fu PP - Int J Environ Res Public Health (2005)

Penetration of skin and eye by solar radiation. (A) Diagram of skin. (B) Diagram of eye.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814709&req=5

f9-ijerph-02-00147: Penetration of skin and eye by solar radiation. (A) Diagram of skin. (B) Diagram of eye.
Mentions: The depth to which solar radiation penetrates tissues, and thereby induces adverse biological effects, depends strongly on its wavelength. In addition, the spectral transmission/absorption characteristics of solar-exposed tissues (Figure 9) influence penetration of light. These and other factors result in the generation of action spectra for photoinjuries to skin and eye components. The action spectra for each photohazard category (Figure 10) were applied to the most sensitive components of the eye or skin to arrive at threshold limit values (TLV) for ocular and cutaneous exposures to monochromatic and broadband light sources. The TLV were established in 1996 by the American Conference of Governmental Industrial Hygenists (ACGIH) (30).

Bottom Line: Sunlight is a known human carcinogen.Many cosmetics contain retinoid-based compounds, such as retinyl palmitate (RP), either to protect the skin or to stimulate skin responses that will correct skin damaged by sunlight.This paper reports the update information and our experimental results on photostability, photoreactions, and phototoxicity of the natural retinoids including retinol (ROH), retinal, retinoid acid (RA), retinyl acetate, and RP (Figure 1).

View Article: PubMed Central - PubMed

Affiliation: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.

ABSTRACT
Sunlight is a known human carcinogen. Many cosmetics contain retinoid-based compounds, such as retinyl palmitate (RP), either to protect the skin or to stimulate skin responses that will correct skin damaged by sunlight. However, little is known about the photodecomposition of some retinoids and the toxicity of these retinoids and their sunlight-induced photodecomposition products on skin. Thus, studies are required to test whether topical application of retinoids enhances the phototoxicity and photocarcinogenicity of sunlight and UV light. Mechanistic studies are needed to provide insight into the disposition of retinoids in vitro and on the skin, and to test thoroughly whether genotoxic damage by UV-induced radicals may participate in any toxicity of topically applied retinoids in the presence of UV light. This paper reports the update information and our experimental results on photostability, photoreactions, and phototoxicity of the natural retinoids including retinol (ROH), retinal, retinoid acid (RA), retinyl acetate, and RP (Figure 1).

Show MeSH
Related in: MedlinePlus