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Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results.

Ghanaati S, Barbeck M, Lorenz J, Stuebinger S, Seitz O, Landes C, Kovács AF, Kirkpatrick CJ, Sader RA - Ann Maxillofac Surg (2013)

Bottom Line: Histologically, NB underwent a higher vascularization and induced significantly more tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated giant cells when compared with BO, which induced mainly mononuclear cells.No significant difference was observed in the extent of new bone formation between both groups.The clinical follow-up showed undisturbed healing of all implants in the BO-group, whereas the loss of one implant was observed in the NB-group.

View Article: PubMed Central - PubMed

Affiliation: Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany ; REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

ABSTRACT

Background: The present study was first to evaluate the material-specific cellular tissue response of patients with head and neck cancer to a nanocrystalline hydroxyapatite bone substitute NanoBone (NB) in comparison with a deproteinized bovine bone matrix Bio-Oss (BO) after implantation into the sinus cavity.

Materials and methods: Eight patients with tumor resection for oral cancer and severely resorbed maxillary bone received materials according to a split mouth design for 6 months. Bone cores were harvested prior to implantation and analyzed histologically and histomorphometrically. Implant survival was followed-up to 2 years after placement.

Results: Histologically, NB underwent a higher vascularization and induced significantly more tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated giant cells when compared with BO, which induced mainly mononuclear cells. No significant difference was observed in the extent of new bone formation between both groups. The clinical follow-up showed undisturbed healing of all implants in the BO-group, whereas the loss of one implant was observed in the NB-group.

Conclusions: Within its limits, the present study showed for the first time that both material classes evaluated, despite their induction of different cellular tissue reactions, may be useful as augmentation materials for dental and maxillofacial surgical applications, particularly in patients who previously had oral cancer.

No MeSH data available.


Related in: MedlinePlus

The histomorphometrical analysis of the tissue distribution within the implantation beds of the two analyzed bone substitute materials, i.e., the measurements of the contained new bone tissue, connective tissue and remaining amount of the materials (**/*** = statistical significance)
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Figure 4: The histomorphometrical analysis of the tissue distribution within the implantation beds of the two analyzed bone substitute materials, i.e., the measurements of the contained new bone tissue, connective tissue and remaining amount of the materials (**/*** = statistical significance)

Mentions: The histomorphometrical analysis of the extracted bone cores focused on the distribution of connective tissue, new BT and remaining bone substitute. The samples of the study group augmented with NB showed values of 53.87 ± 5.12% for connective tissue, 21.85 ± 5.96% for newly formed bone and 24.28 ± 3.26% for the remaining bone substitute [Figure 4]. The values in the BO group were 34.14 ± 4.45% for connective tissue, 25.73 ± 7.94% for newly formed bone and 40.13 ± 3.53% for the remaining bone substitute [Figure 4]. Further statistical analysis revealed a significantly higher fraction of the remaining bone substitute in the BO group (**P > 0.01) than in the NB group. The fraction of connective tissue was significantly lower in the BO group than in the NB group (***P > 0.001). No significant differences were observed for BT formation between the two groups [Figure 4]. In addition, significantly more BO than newly formed BT was found in the implantation beds of the BO group (*P > 0.05) [Figure 4].


Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results.

Ghanaati S, Barbeck M, Lorenz J, Stuebinger S, Seitz O, Landes C, Kovács AF, Kirkpatrick CJ, Sader RA - Ann Maxillofac Surg (2013)

The histomorphometrical analysis of the tissue distribution within the implantation beds of the two analyzed bone substitute materials, i.e., the measurements of the contained new bone tissue, connective tissue and remaining amount of the materials (**/*** = statistical significance)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814660&req=5

Figure 4: The histomorphometrical analysis of the tissue distribution within the implantation beds of the two analyzed bone substitute materials, i.e., the measurements of the contained new bone tissue, connective tissue and remaining amount of the materials (**/*** = statistical significance)
Mentions: The histomorphometrical analysis of the extracted bone cores focused on the distribution of connective tissue, new BT and remaining bone substitute. The samples of the study group augmented with NB showed values of 53.87 ± 5.12% for connective tissue, 21.85 ± 5.96% for newly formed bone and 24.28 ± 3.26% for the remaining bone substitute [Figure 4]. The values in the BO group were 34.14 ± 4.45% for connective tissue, 25.73 ± 7.94% for newly formed bone and 40.13 ± 3.53% for the remaining bone substitute [Figure 4]. Further statistical analysis revealed a significantly higher fraction of the remaining bone substitute in the BO group (**P > 0.01) than in the NB group. The fraction of connective tissue was significantly lower in the BO group than in the NB group (***P > 0.001). No significant differences were observed for BT formation between the two groups [Figure 4]. In addition, significantly more BO than newly formed BT was found in the implantation beds of the BO group (*P > 0.05) [Figure 4].

Bottom Line: Histologically, NB underwent a higher vascularization and induced significantly more tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated giant cells when compared with BO, which induced mainly mononuclear cells.No significant difference was observed in the extent of new bone formation between both groups.The clinical follow-up showed undisturbed healing of all implants in the BO-group, whereas the loss of one implant was observed in the NB-group.

View Article: PubMed Central - PubMed

Affiliation: Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany ; REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

ABSTRACT

Background: The present study was first to evaluate the material-specific cellular tissue response of patients with head and neck cancer to a nanocrystalline hydroxyapatite bone substitute NanoBone (NB) in comparison with a deproteinized bovine bone matrix Bio-Oss (BO) after implantation into the sinus cavity.

Materials and methods: Eight patients with tumor resection for oral cancer and severely resorbed maxillary bone received materials according to a split mouth design for 6 months. Bone cores were harvested prior to implantation and analyzed histologically and histomorphometrically. Implant survival was followed-up to 2 years after placement.

Results: Histologically, NB underwent a higher vascularization and induced significantly more tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated giant cells when compared with BO, which induced mainly mononuclear cells. No significant difference was observed in the extent of new bone formation between both groups. The clinical follow-up showed undisturbed healing of all implants in the BO-group, whereas the loss of one implant was observed in the NB-group.

Conclusions: Within its limits, the present study showed for the first time that both material classes evaluated, despite their induction of different cellular tissue reactions, may be useful as augmentation materials for dental and maxillofacial surgical applications, particularly in patients who previously had oral cancer.

No MeSH data available.


Related in: MedlinePlus