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Comparison of Alopecia severity and blood level of testosterone in men suffering schizophrenia with control group.

Kheirabadi GR, Yazdani A, Golfam L - Adv Biomed Res (2013)

Bottom Line: Collected data were analyzed using SPSS 19 software and statistical tests of χ(2) and logistic Regression.The mean blood level of testosterone in both studied and control groups were 458.80 ± 103 and 476.34 ± 108, respectively, having no significant difference (P > 0.05).And in comparison of two groups, providing Androgenic Alopecia with a degree higher than three in Hamilton Scale, schizophrenia risk decreases 8.627 times.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Testosterone causes Alopecia that is related to functional testosterone and end organ sensitivity to testosterone. Studies conducted on the relationship of schizophrenia and testosterone have reported different findings. This study was designed to measure the extent of Alopecia in schizophrenic patients which is one of the most important signs of sensitivity to Androgens.

Materials and methods: In a cross-sectional study, 98 schizophrenic patients and 95 person of normal population encountered to study in two groups considering inclusion criteria and completing a consent form, in the psychiatric ward of Noor Hospital in Isfahan, Iran. Meanwhile, the record of necessary demographic information a blood sample was taken from every selected person to measure the blood level of testosterone. The severity of Alopecia was measured using Hamilton and Norwood criterion in a blindness condition. Collected data were analyzed using SPSS 19 software and statistical tests of χ(2) and logistic Regression.

Results: The mean blood level of testosterone in both studied and control groups were 458.80 ± 103 and 476.34 ± 108, respectively, having no significant difference (P > 0.05). There was no significant relationship in both groups between Alopecia severity and the blood level of testosterone. And in comparison of two groups, providing Androgenic Alopecia with a degree higher than three in Hamilton Scale, schizophrenia risk decreases 8.627 times.

Conclusion: Sensitivity to Androgens and Alopecia probably plays a protective role against schizophrenia, and if Alopecia rate exceeds the rate of grade 2 Hamilton, the risk of schizophrenia decreases 8.62 times.

No MeSH data available.


Related in: MedlinePlus

Visual pattern of hamilton-norwood scale for determination of Androgenic Alopecia severity in men
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Figure 1: Visual pattern of hamilton-norwood scale for determination of Androgenic Alopecia severity in men

Mentions: In this test, 7 steps are defined for determining the severity of Alopecia [Figure 1], Step 1: No Alopecia is observed and the person has normal hair pattern, Step 2: Hair on the front side of the head becomes triquetrous due to margents’ Alopecia, Step 3: Has the same pattern as step 2, but the shed area has expanded further towards the Frontal-temporal part of the head, Step 4: Shed areas of the head have completely expanded towards the Frontal-temporal part, and a separate Alopecia is begun from the upper back of the head, Step 5: The Alopecia pattern of step 4 is extended and the density of remained hair has significantly decreased in these areas, Step 6: The narrow strip of hair separating the bald part of the back and front of the head in stages 4 and 5 is vanished, and no hair is visible in scalp from front to back, Step 7: Alopecia has extended from back to down and from sides to upper part of the earlobe.


Comparison of Alopecia severity and blood level of testosterone in men suffering schizophrenia with control group.

Kheirabadi GR, Yazdani A, Golfam L - Adv Biomed Res (2013)

Visual pattern of hamilton-norwood scale for determination of Androgenic Alopecia severity in men
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814638&req=5

Figure 1: Visual pattern of hamilton-norwood scale for determination of Androgenic Alopecia severity in men
Mentions: In this test, 7 steps are defined for determining the severity of Alopecia [Figure 1], Step 1: No Alopecia is observed and the person has normal hair pattern, Step 2: Hair on the front side of the head becomes triquetrous due to margents’ Alopecia, Step 3: Has the same pattern as step 2, but the shed area has expanded further towards the Frontal-temporal part of the head, Step 4: Shed areas of the head have completely expanded towards the Frontal-temporal part, and a separate Alopecia is begun from the upper back of the head, Step 5: The Alopecia pattern of step 4 is extended and the density of remained hair has significantly decreased in these areas, Step 6: The narrow strip of hair separating the bald part of the back and front of the head in stages 4 and 5 is vanished, and no hair is visible in scalp from front to back, Step 7: Alopecia has extended from back to down and from sides to upper part of the earlobe.

Bottom Line: Collected data were analyzed using SPSS 19 software and statistical tests of χ(2) and logistic Regression.The mean blood level of testosterone in both studied and control groups were 458.80 ± 103 and 476.34 ± 108, respectively, having no significant difference (P > 0.05).And in comparison of two groups, providing Androgenic Alopecia with a degree higher than three in Hamilton Scale, schizophrenia risk decreases 8.627 times.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Testosterone causes Alopecia that is related to functional testosterone and end organ sensitivity to testosterone. Studies conducted on the relationship of schizophrenia and testosterone have reported different findings. This study was designed to measure the extent of Alopecia in schizophrenic patients which is one of the most important signs of sensitivity to Androgens.

Materials and methods: In a cross-sectional study, 98 schizophrenic patients and 95 person of normal population encountered to study in two groups considering inclusion criteria and completing a consent form, in the psychiatric ward of Noor Hospital in Isfahan, Iran. Meanwhile, the record of necessary demographic information a blood sample was taken from every selected person to measure the blood level of testosterone. The severity of Alopecia was measured using Hamilton and Norwood criterion in a blindness condition. Collected data were analyzed using SPSS 19 software and statistical tests of χ(2) and logistic Regression.

Results: The mean blood level of testosterone in both studied and control groups were 458.80 ± 103 and 476.34 ± 108, respectively, having no significant difference (P > 0.05). There was no significant relationship in both groups between Alopecia severity and the blood level of testosterone. And in comparison of two groups, providing Androgenic Alopecia with a degree higher than three in Hamilton Scale, schizophrenia risk decreases 8.627 times.

Conclusion: Sensitivity to Androgens and Alopecia probably plays a protective role against schizophrenia, and if Alopecia rate exceeds the rate of grade 2 Hamilton, the risk of schizophrenia decreases 8.62 times.

No MeSH data available.


Related in: MedlinePlus