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Effects of different doses of doxepin on passive avoidance learning in rats.

Gharzi M, Dolatabadi HR, Reisi P, Javanmard SH - Adv Biomed Res (2013)

Bottom Line: Studies have shown that Doxepin has anti-inflammatory effects and reduces oxidative stress.These results indicate that Doxepin has desirable effects on cognitive functions in low doses.Therefore, Doxepin can be considered as memory enhancers that understanding the underling mechanisms need further investigation.

View Article: PubMed Central - PubMed

Affiliation: Applied Physiology Research Center, Isfahan, Iran.

ABSTRACT

Background: Studies have shown that Doxepin has anti-inflammatory effects and reduces oxidative stress. Due to the fact that other tricyclic antidepressants have been shown to have neuroprotective effects, this study aimed to investigate the effects of different doses of doxepin on passive avoidance learning in rats.

Materials and methods: Old male Wistar rats were used in this study. Doxepin was administered intraperitoneally (1, 5 and 10 mg/kg) for 21 days. Passive avoidance learning test was used for evaluation of learning and memory. Rats received foot electrical shock on fifteen day, and step through latencies were evaluated one week after the electrical shock in retention phase.

Results: Administration of Doxepin considerably increased the step through latencies in the rats that received the doses of 1 and 5 mg/kg (P < 0.05). However, in the dose of 10 mg/kg, there wasn't any significant change comparing to control group.

Conclusion: These results indicate that Doxepin has desirable effects on cognitive functions in low doses. Therefore, Doxepin can be considered as memory enhancers that understanding the underling mechanisms need further investigation.

No MeSH data available.


Related in: MedlinePlus

Dose-related effects of doxepin on initial latency in rats. Data are expressed as mean ± SEM. (n = 8)
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Figure 1: Dose-related effects of doxepin on initial latency in rats. Data are expressed as mean ± SEM. (n = 8)

Mentions: The mean initial latency in the acquisition trial wasn’t different among the groups significantly [control: 25.4 ± 11.96; Doxepin 1, 5, 10 mg: 29.4 ± 5.08, 17.8 ± 5.91, 18.78 ± 5.91 respectively; P = 0.43; [Figure 1]. Results from the retention phase of PAL as measured by mean retention latency time have shown twenty four hours after acquisition phase, mean retention latencies except in the Doxepin treated group 10 mg/kg (352.9 ± 89.98 s) was increased in Doxepin treated groups 1 mg/kg (549.12 ± 30.53 s; P < 0.05) and 5 mg/kg (553.57 ± 31.83 s; P < 0.05) than the control group (398.5 ± 72.3 s). Also, mean retention latency time was further significantly (P < 0.05) in Doxepin treated groups 1 mg/kg and 5 mg/kg comparing to the Doxepin treated group 10 mg/kg [Figure 2].


Effects of different doses of doxepin on passive avoidance learning in rats.

Gharzi M, Dolatabadi HR, Reisi P, Javanmard SH - Adv Biomed Res (2013)

Dose-related effects of doxepin on initial latency in rats. Data are expressed as mean ± SEM. (n = 8)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814585&req=5

Figure 1: Dose-related effects of doxepin on initial latency in rats. Data are expressed as mean ± SEM. (n = 8)
Mentions: The mean initial latency in the acquisition trial wasn’t different among the groups significantly [control: 25.4 ± 11.96; Doxepin 1, 5, 10 mg: 29.4 ± 5.08, 17.8 ± 5.91, 18.78 ± 5.91 respectively; P = 0.43; [Figure 1]. Results from the retention phase of PAL as measured by mean retention latency time have shown twenty four hours after acquisition phase, mean retention latencies except in the Doxepin treated group 10 mg/kg (352.9 ± 89.98 s) was increased in Doxepin treated groups 1 mg/kg (549.12 ± 30.53 s; P < 0.05) and 5 mg/kg (553.57 ± 31.83 s; P < 0.05) than the control group (398.5 ± 72.3 s). Also, mean retention latency time was further significantly (P < 0.05) in Doxepin treated groups 1 mg/kg and 5 mg/kg comparing to the Doxepin treated group 10 mg/kg [Figure 2].

Bottom Line: Studies have shown that Doxepin has anti-inflammatory effects and reduces oxidative stress.These results indicate that Doxepin has desirable effects on cognitive functions in low doses.Therefore, Doxepin can be considered as memory enhancers that understanding the underling mechanisms need further investigation.

View Article: PubMed Central - PubMed

Affiliation: Applied Physiology Research Center, Isfahan, Iran.

ABSTRACT

Background: Studies have shown that Doxepin has anti-inflammatory effects and reduces oxidative stress. Due to the fact that other tricyclic antidepressants have been shown to have neuroprotective effects, this study aimed to investigate the effects of different doses of doxepin on passive avoidance learning in rats.

Materials and methods: Old male Wistar rats were used in this study. Doxepin was administered intraperitoneally (1, 5 and 10 mg/kg) for 21 days. Passive avoidance learning test was used for evaluation of learning and memory. Rats received foot electrical shock on fifteen day, and step through latencies were evaluated one week after the electrical shock in retention phase.

Results: Administration of Doxepin considerably increased the step through latencies in the rats that received the doses of 1 and 5 mg/kg (P < 0.05). However, in the dose of 10 mg/kg, there wasn't any significant change comparing to control group.

Conclusion: These results indicate that Doxepin has desirable effects on cognitive functions in low doses. Therefore, Doxepin can be considered as memory enhancers that understanding the underling mechanisms need further investigation.

No MeSH data available.


Related in: MedlinePlus