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A rare case of laryngotracheal chondrosarcoma in a patient with past history of radioiodine therapy for thyroid cancer.

Mohajeri G, Hekmatnia A, Ahrar H, Hekmatnia F, Nia RB, Afsharmoghadam N, Eftekhari M, Jafarpishe S - Adv Biomed Res (2013)

Bottom Line: Tracheal chondrosarcoma is a rare malignant mesenchymal tumor and there are less than 15 reports in the literature.We report a rare case of laryngotracheal chondrosarcoma in a 74-year-old man.He gave a history of radioiodine therapy for thyroid papillary carcinoma about 24 years ago.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Image Processing and Signal Research Center, Isfahan, Iran.

ABSTRACT
Tracheal chondrosarcoma is a rare malignant mesenchymal tumor and there are less than 15 reports in the literature. We report a rare case of laryngotracheal chondrosarcoma in a 74-year-old man. He gave a history of radioiodine therapy for thyroid papillary carcinoma about 24 years ago. Diagnostic steps, histological presentation, and therapy are described in detail.

No MeSH data available.


Related in: MedlinePlus

Representative section revealed basophile hyaline chondroid matrix, typical lobulated architecture, increased cellularity, and mild cellular atypia, consistent with low-grade chondrosarcoma (H and E, ×400)
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Figure 2: Representative section revealed basophile hyaline chondroid matrix, typical lobulated architecture, increased cellularity, and mild cellular atypia, consistent with low-grade chondrosarcoma (H and E, ×400)

Mentions: In order to reconstruct the airway, the trachea was cut in the shape of the letter L. So, the left and longer side of the trachea was sutured to the thyroid cartilage and the short right side to right half of the cricoid cartilage. Fiberoptic bronchoscopy was used for airway assessment and the patient was put on orotracheal intubation for 48 h. After extubation 48 h later, good phonation was observed in the patient without any respiratory problems. The patient was discharged from the hospital without any complications. In gross pathologic examination, the specimen consisted of a fragment of trachea measuring 4 × 3 × 2 cm that in cut section showed a polypoid mass in the inner wall with chondroid consistency and gray color. Microscopically, the sections revealed neoplastic proliferation of chondrocytes in a pale, basophilic, hyaline chondroid matrix. The chondrocytes showed increased nuclear-to-cytoplasmic ratios, irregular nuclear membranes, and nucleoli. Mitotic activity was scant, but cellularity was markedly increased and several chondrocytes were seen on a single lacuna, indicating low-grade chondrosarcoma [Figure 2].


A rare case of laryngotracheal chondrosarcoma in a patient with past history of radioiodine therapy for thyroid cancer.

Mohajeri G, Hekmatnia A, Ahrar H, Hekmatnia F, Nia RB, Afsharmoghadam N, Eftekhari M, Jafarpishe S - Adv Biomed Res (2013)

Representative section revealed basophile hyaline chondroid matrix, typical lobulated architecture, increased cellularity, and mild cellular atypia, consistent with low-grade chondrosarcoma (H and E, ×400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814568&req=5

Figure 2: Representative section revealed basophile hyaline chondroid matrix, typical lobulated architecture, increased cellularity, and mild cellular atypia, consistent with low-grade chondrosarcoma (H and E, ×400)
Mentions: In order to reconstruct the airway, the trachea was cut in the shape of the letter L. So, the left and longer side of the trachea was sutured to the thyroid cartilage and the short right side to right half of the cricoid cartilage. Fiberoptic bronchoscopy was used for airway assessment and the patient was put on orotracheal intubation for 48 h. After extubation 48 h later, good phonation was observed in the patient without any respiratory problems. The patient was discharged from the hospital without any complications. In gross pathologic examination, the specimen consisted of a fragment of trachea measuring 4 × 3 × 2 cm that in cut section showed a polypoid mass in the inner wall with chondroid consistency and gray color. Microscopically, the sections revealed neoplastic proliferation of chondrocytes in a pale, basophilic, hyaline chondroid matrix. The chondrocytes showed increased nuclear-to-cytoplasmic ratios, irregular nuclear membranes, and nucleoli. Mitotic activity was scant, but cellularity was markedly increased and several chondrocytes were seen on a single lacuna, indicating low-grade chondrosarcoma [Figure 2].

Bottom Line: Tracheal chondrosarcoma is a rare malignant mesenchymal tumor and there are less than 15 reports in the literature.We report a rare case of laryngotracheal chondrosarcoma in a 74-year-old man.He gave a history of radioiodine therapy for thyroid papillary carcinoma about 24 years ago.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Image Processing and Signal Research Center, Isfahan, Iran.

ABSTRACT
Tracheal chondrosarcoma is a rare malignant mesenchymal tumor and there are less than 15 reports in the literature. We report a rare case of laryngotracheal chondrosarcoma in a 74-year-old man. He gave a history of radioiodine therapy for thyroid papillary carcinoma about 24 years ago. Diagnostic steps, histological presentation, and therapy are described in detail.

No MeSH data available.


Related in: MedlinePlus