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Increased resistin serum concentrations in patientswith type 1 diabetes mellitus.

Geyikli I, Keskin M, Kör Y, Akan M - J Clin Res Pediatr Endocrinol (2013)

Bottom Line: All subjects were patients followed in the Pediatric Endocrinology and Metabolism Unit of Gaziantep University Faculty of Medicine.None of the subjects had hypertension, obesity, hyperlipidemia, anemia, or infection.There were no statistically significant differences related with age, sex, pubertal status, or body mass index distribution between the diabetic and control groups.

View Article: PubMed Central - PubMed

Affiliation: Gaziantep University, Faculty of Medicine, Pediatric Endocrinology and Metabolisms, Gaziantep, Turkey. E-mail: mkeskin@gantep.edu.tr.

ABSTRACT

Objective: Adiponectin, leptin, and resistin are adipokines which play a significant role in the regulation of lipid and carbohydrate metabolism in patients with type 2 diabetes, while little is known about their role in type 1 diabetes mellitus (T1DM). The aim of this study was to measure serum adiponectin, leptin, and resistin levels and to investigate their relationships with some parameters in patients with T1DM and healthy controls.

Methods: Fifty children and adolescents with T1DM (21 boys and 29 girls) and 33 healthy control subjects (18 boys and 15 girls) participated in the study. All subjects were patients followed in the Pediatric Endocrinology and Metabolism Unit of Gaziantep University Faculty of Medicine. None of the subjects had hypertension, obesity, hyperlipidemia, anemia, or infection. Adiponectin, leptin, and resistin levels were analyzed with ELISA.

Results: There were no statistically significant differences related with age, sex, pubertal status, or body mass index distribution between the diabetic and control groups. Resistin levels were significantly higher in the diabetic group compared to controls (5.26±3.15 ng/mL vs. 3.50±1.26 ng/mL; p<0.01).

Conclusion: Of the three investigated adipokines, only resistin was associated with T1DM. Resistin may play a role in the process of inflammation and also in the pathophysiology of T1DM.

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Related in: MedlinePlus

Mean (±SD) values of adiponectin, resistin and median (25th; 75th percentile) value of leptin levels in children with type 1 diabetes mellitus and age-and sex-matched controls
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f1: Mean (±SD) values of adiponectin, resistin and median (25th; 75th percentile) value of leptin levels in children with type 1 diabetes mellitus and age-and sex-matched controls

Mentions: The male/female ratio of the diabetic group was 21/29. Mean diabetic duration was 2.96±2.63 years. Demographic and clinical characteristic of the diabetic patients are shown in Table 1. In the control group, male/female ratio was 18/15 and mean age was 9.70±4.39 years. There were no statistically significant differences in age, sex, or pubertal status between the patient and control groups. BMI distribution between the diabetic and control groups was similar (p>0.05). Resistin levels were significantly higher in the diabetic group compared to controls (5.26±3.15 ng/mL vs. 3.50±1.26 ng/mL; p<0.01). There were no significant differences in mean adiponectin (10.88±5.98µg/mL vs. 9.04±5.69 µg/mL) and median (interquartile) leptin (2.48 ng/mL vs. 2.51 ng/mL) levels between the two groups. Mean (±SD) values for adiponectin, resistin, and median (25th; 75th percentile) values for leptin levels in children with T1DM and age-and sex-matched controls are shown in Figure 1. Analysis investigating the correlation of adipokine levels with HbA1c, diabetes duration, BMI, and age showed a positive correlation between HbA1c and resistin levels (r=0.321, p=0.03). Adipokines were not interrelated.


Increased resistin serum concentrations in patientswith type 1 diabetes mellitus.

Geyikli I, Keskin M, Kör Y, Akan M - J Clin Res Pediatr Endocrinol (2013)

Mean (±SD) values of adiponectin, resistin and median (25th; 75th percentile) value of leptin levels in children with type 1 diabetes mellitus and age-and sex-matched controls
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814534&req=5

f1: Mean (±SD) values of adiponectin, resistin and median (25th; 75th percentile) value of leptin levels in children with type 1 diabetes mellitus and age-and sex-matched controls
Mentions: The male/female ratio of the diabetic group was 21/29. Mean diabetic duration was 2.96±2.63 years. Demographic and clinical characteristic of the diabetic patients are shown in Table 1. In the control group, male/female ratio was 18/15 and mean age was 9.70±4.39 years. There were no statistically significant differences in age, sex, or pubertal status between the patient and control groups. BMI distribution between the diabetic and control groups was similar (p>0.05). Resistin levels were significantly higher in the diabetic group compared to controls (5.26±3.15 ng/mL vs. 3.50±1.26 ng/mL; p<0.01). There were no significant differences in mean adiponectin (10.88±5.98µg/mL vs. 9.04±5.69 µg/mL) and median (interquartile) leptin (2.48 ng/mL vs. 2.51 ng/mL) levels between the two groups. Mean (±SD) values for adiponectin, resistin, and median (25th; 75th percentile) values for leptin levels in children with T1DM and age-and sex-matched controls are shown in Figure 1. Analysis investigating the correlation of adipokine levels with HbA1c, diabetes duration, BMI, and age showed a positive correlation between HbA1c and resistin levels (r=0.321, p=0.03). Adipokines were not interrelated.

Bottom Line: All subjects were patients followed in the Pediatric Endocrinology and Metabolism Unit of Gaziantep University Faculty of Medicine.None of the subjects had hypertension, obesity, hyperlipidemia, anemia, or infection.There were no statistically significant differences related with age, sex, pubertal status, or body mass index distribution between the diabetic and control groups.

View Article: PubMed Central - PubMed

Affiliation: Gaziantep University, Faculty of Medicine, Pediatric Endocrinology and Metabolisms, Gaziantep, Turkey. E-mail: mkeskin@gantep.edu.tr.

ABSTRACT

Objective: Adiponectin, leptin, and resistin are adipokines which play a significant role in the regulation of lipid and carbohydrate metabolism in patients with type 2 diabetes, while little is known about their role in type 1 diabetes mellitus (T1DM). The aim of this study was to measure serum adiponectin, leptin, and resistin levels and to investigate their relationships with some parameters in patients with T1DM and healthy controls.

Methods: Fifty children and adolescents with T1DM (21 boys and 29 girls) and 33 healthy control subjects (18 boys and 15 girls) participated in the study. All subjects were patients followed in the Pediatric Endocrinology and Metabolism Unit of Gaziantep University Faculty of Medicine. None of the subjects had hypertension, obesity, hyperlipidemia, anemia, or infection. Adiponectin, leptin, and resistin levels were analyzed with ELISA.

Results: There were no statistically significant differences related with age, sex, pubertal status, or body mass index distribution between the diabetic and control groups. Resistin levels were significantly higher in the diabetic group compared to controls (5.26±3.15 ng/mL vs. 3.50±1.26 ng/mL; p<0.01).

Conclusion: Of the three investigated adipokines, only resistin was associated with T1DM. Resistin may play a role in the process of inflammation and also in the pathophysiology of T1DM.

Show MeSH
Related in: MedlinePlus