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Anonymous Record Linkage Between EPR and CDW-H: Toward Development of a Federated Genotype-Phenotype System.

Pu D, Garantziotis S, Mostafa J - AMIA Jt Summits Transl Sci Proc (2013)

Bottom Line: CDW-H contains clinically-relevant data for patients who have been admitted to UNC healthcare system.To validate the feasibility of linking EPR with CDWH, the number of matching records between the two databases had to be established.Preliminary results showed that combination of last name, gender, data of birth and zip code would generate over 2,700 matches between the two databases.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Applied Informatics Research, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA ; The North Carolina Translational & Clinical Science (TraCS) Institute, Chapel Hill, NC, USA.

ABSTRACT
Environmental Polymorphisms Registry (EPR) is a large-scale phenotype-by-genotype registry developed by National Institute of Environmental Health Sciences to facilitate translational research. The link between personal identity and collected genomic data was preserved in EPR which creates opportunities for EPR to be linked to phenotype-rich databases, such as the Carolina Data Warehouse for Health (CDW-H) located at the University of North Carolina hospital system. CDW-H contains clinically-relevant data for patients who have been admitted to UNC healthcare system. To validate the feasibility of linking EPR with CDWH, the number of matching records between the two databases had to be established. To that end, combinations of subjects' demographic identifiers from both databases were converted to anonymized hash codes, which were then matched to determine the number of overlapping records. Preliminary results showed that combination of last name, gender, data of birth and zip code would generate over 2,700 matches between the two databases.

No MeSH data available.


Related in: MedlinePlus

Project workflow for anonymized record linkage
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Related In: Results  -  Collection


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f1-amia_tbi_2013_143: Project workflow for anonymized record linkage

Mentions: Figure 1 displays the coordination between the two agencies in performing this research. Note that, to ensure research staff will not have access to data from the other organization, the hashing application developed at UNC was delivered to NIEHS so that the hashing process could be performed separately at NIEHS. Hash codes from NIEHS were then delivered to a centralized repository at UNC through a secure ftp server. The anonymized record linkage step was performed at UNC and data was immediately destroyed upon completion.


Anonymous Record Linkage Between EPR and CDW-H: Toward Development of a Federated Genotype-Phenotype System.

Pu D, Garantziotis S, Mostafa J - AMIA Jt Summits Transl Sci Proc (2013)

Project workflow for anonymized record linkage
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814467&req=5

f1-amia_tbi_2013_143: Project workflow for anonymized record linkage
Mentions: Figure 1 displays the coordination between the two agencies in performing this research. Note that, to ensure research staff will not have access to data from the other organization, the hashing application developed at UNC was delivered to NIEHS so that the hashing process could be performed separately at NIEHS. Hash codes from NIEHS were then delivered to a centralized repository at UNC through a secure ftp server. The anonymized record linkage step was performed at UNC and data was immediately destroyed upon completion.

Bottom Line: CDW-H contains clinically-relevant data for patients who have been admitted to UNC healthcare system.To validate the feasibility of linking EPR with CDWH, the number of matching records between the two databases had to be established.Preliminary results showed that combination of last name, gender, data of birth and zip code would generate over 2,700 matches between the two databases.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Applied Informatics Research, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA ; The North Carolina Translational & Clinical Science (TraCS) Institute, Chapel Hill, NC, USA.

ABSTRACT
Environmental Polymorphisms Registry (EPR) is a large-scale phenotype-by-genotype registry developed by National Institute of Environmental Health Sciences to facilitate translational research. The link between personal identity and collected genomic data was preserved in EPR which creates opportunities for EPR to be linked to phenotype-rich databases, such as the Carolina Data Warehouse for Health (CDW-H) located at the University of North Carolina hospital system. CDW-H contains clinically-relevant data for patients who have been admitted to UNC healthcare system. To validate the feasibility of linking EPR with CDWH, the number of matching records between the two databases had to be established. To that end, combinations of subjects' demographic identifiers from both databases were converted to anonymized hash codes, which were then matched to determine the number of overlapping records. Preliminary results showed that combination of last name, gender, data of birth and zip code would generate over 2,700 matches between the two databases.

No MeSH data available.


Related in: MedlinePlus