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The usefulness of F-18 FDG PET/CT-mammography for preoperative staging of breast cancer: comparison with conventional PET/CT and MR-mammography.

Moon EH, Lim ST, Han YH, Jeong YJ, Kang YH, Jeong HJ, Sohn MH - Radiol Oncol (2013)

Bottom Line: No significant difference was found in the number of metastatic axillary lymph nodes.In the T-stage, 72.5% of cases with mammo-PET/CT and 70% of cases with MR-mammography showed correspondence with pathologic results.Mammo-PET/CT provided more correct definition of the T-stage and evaluation of axillary fossa may also be delineated more clearly than with supine-PET/CT.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, Korea ; Department of Nuclear Medicine, Presbyterian Medical Center, Jeonju, Jeonbuk, Korea.

ABSTRACT

Background: The objective of the study was to compare the diagnostic efficacy of an integrated Fluorine-18 fluorodeoxyglucose (F-18 FDG) PET/CT-mammography (mammo-PET/CT) with conventional torso PET/CT (supine-PET/CT) and MR-mammography for initial assessment of breast cancer patients.

Patients and methods: Forty women (52.0 ± 12.0 years) with breast cancer who underwent supine-PET/CT, mammo-PET/CT, and MR-mammography from April 2009 to August 2009 were enrolled in the study. We compared the size of the tumour, tumour to chest wall distance, tumour to skin distance, volume of axillary fossa, and number of meta-static axillary lymph nodes between supine-PET/CT and mammo-PET/CT. Next, we assessed the difference of focality of primary breast tumour and tumour size in mammo-PET/CT and MR-mammography. Histopathologic findings served as the standard of reference.

Results: In the comparison between supine-PET/CT and mammo-PET/CT, significant differences were found in the tumour size (supine-PET/CT: 1.3 ± 0.6 cm, mammo-PET/CT: 1.5 ± 0.6 cm, p < 0.001), tumour to thoracic wall distance (1.8 ± 0.9 cm, 2.2 ± 2.1 cm, p < 0.001), and tumour to skin distance (1.5 ± 0.8 cm, 2.1 ± 1.4 cm, p < 0.001). The volume of axillary fossa was significantly wider in mammo-PET/CT than supine-PET/CT (21.7 ± 8.7 cm(3) vs. 23.4 ± 10.4 cm(3), p = 0.03). Mammo-PET/CT provided more correct definition of the T-stage of the primary tumour than did supine-PET/CT (72.5% vs. 67.5%). No significant difference was found in the number of metastatic axillary lymph nodes. Compared with MR-mammography, mammo-PET/CT provided more correct classification of the focality of lesion than did MR-mammography (95% vs. 90%). In the T-stage, 72.5% of cases with mammo-PET/CT and 70% of cases with MR-mammography showed correspondence with pathologic results.

Conclusions: Mammo-PET/CT provided more correct definition of the T-stage and evaluation of axillary fossa may also be delineated more clearly than with supine-PET/CT. The initial assessment of mammo-PET/CT would be more useful than MR-mammography because the mammo-PET/CT indicates similar accuracy with MR-mammography for decision of T-stage of primary breast tumour and more correct than MR-mammography for defining focality of lesion.

No MeSH data available.


Related in: MedlinePlus

A woman with right breast cancer performed the supine-PET/CT and mammo-PET/CT. A The primary tumour was abutted on the chest wall in the supine-PET/CT. BThe tumour could be more clearly distinguished from the chest wall in the mammo-PET/CT.
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f2-rado-47-04-390: A woman with right breast cancer performed the supine-PET/CT and mammo-PET/CT. A The primary tumour was abutted on the chest wall in the supine-PET/CT. BThe tumour could be more clearly distinguished from the chest wall in the mammo-PET/CT.

Mentions: The mean size of primary tumour lesions, in the longest axis dimension, was significantly larger on mammo-PET/CT than on supine-PET/CT (supine-PET/CT: 1.3 ± 0.6 cm, mammo-PET/CT: 1.5 ± 0.6 cm, p < 0.001). The difference of tumour size between PET/CT imaging and histopathologic result was 0.5 ± 1.1 cm on supine-PET/CT and 0.2 ± 1.2 cm on mammo-PET/CT. Thus, the real size of the primary tumour was more accurate on mammo-PET/CT than on supine-PET/CT. The mean tumour to chest wall distance (supine-PET/CT: 1.8 ± 0.9 cm, mammo-PET/CT: 2.2 ± 2.1 cm, p < 0.001) and tumour to skin distance (supine-PET/CT: 1.5 ± 0.8 cm, mammo-PET/CT: 2.1 ± 1.4 cm, p < 0.001) were significantly longer on mammo-PET/CT than on supine-PET/CT, indicating better delineation of the tumour from the chest wall and skin (Figure 2, Table 1). The mean SUVmax of the primary tumour was 7.6 ± 5.8 (range: 1.4–20.8) on supine-PET/CT and 8.0 ± 6.2 (range: 1.8–21.4) on mammo-PET/CT (p = 0.02).The mean SUVmax ratio of the primary tumour showed 5.4 (range: 1.4∼30.8) in the supine-PET/CT and 5.7 (1.3∼23.4) in the mammo-PET/CT. No significant difference was showed between the supine-PET/CT and mammo-PET/CT statistically (p = 0.18).


The usefulness of F-18 FDG PET/CT-mammography for preoperative staging of breast cancer: comparison with conventional PET/CT and MR-mammography.

Moon EH, Lim ST, Han YH, Jeong YJ, Kang YH, Jeong HJ, Sohn MH - Radiol Oncol (2013)

A woman with right breast cancer performed the supine-PET/CT and mammo-PET/CT. A The primary tumour was abutted on the chest wall in the supine-PET/CT. BThe tumour could be more clearly distinguished from the chest wall in the mammo-PET/CT.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3814285&req=5

f2-rado-47-04-390: A woman with right breast cancer performed the supine-PET/CT and mammo-PET/CT. A The primary tumour was abutted on the chest wall in the supine-PET/CT. BThe tumour could be more clearly distinguished from the chest wall in the mammo-PET/CT.
Mentions: The mean size of primary tumour lesions, in the longest axis dimension, was significantly larger on mammo-PET/CT than on supine-PET/CT (supine-PET/CT: 1.3 ± 0.6 cm, mammo-PET/CT: 1.5 ± 0.6 cm, p < 0.001). The difference of tumour size between PET/CT imaging and histopathologic result was 0.5 ± 1.1 cm on supine-PET/CT and 0.2 ± 1.2 cm on mammo-PET/CT. Thus, the real size of the primary tumour was more accurate on mammo-PET/CT than on supine-PET/CT. The mean tumour to chest wall distance (supine-PET/CT: 1.8 ± 0.9 cm, mammo-PET/CT: 2.2 ± 2.1 cm, p < 0.001) and tumour to skin distance (supine-PET/CT: 1.5 ± 0.8 cm, mammo-PET/CT: 2.1 ± 1.4 cm, p < 0.001) were significantly longer on mammo-PET/CT than on supine-PET/CT, indicating better delineation of the tumour from the chest wall and skin (Figure 2, Table 1). The mean SUVmax of the primary tumour was 7.6 ± 5.8 (range: 1.4–20.8) on supine-PET/CT and 8.0 ± 6.2 (range: 1.8–21.4) on mammo-PET/CT (p = 0.02).The mean SUVmax ratio of the primary tumour showed 5.4 (range: 1.4∼30.8) in the supine-PET/CT and 5.7 (1.3∼23.4) in the mammo-PET/CT. No significant difference was showed between the supine-PET/CT and mammo-PET/CT statistically (p = 0.18).

Bottom Line: No significant difference was found in the number of metastatic axillary lymph nodes.In the T-stage, 72.5% of cases with mammo-PET/CT and 70% of cases with MR-mammography showed correspondence with pathologic results.Mammo-PET/CT provided more correct definition of the T-stage and evaluation of axillary fossa may also be delineated more clearly than with supine-PET/CT.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, Korea ; Department of Nuclear Medicine, Presbyterian Medical Center, Jeonju, Jeonbuk, Korea.

ABSTRACT

Background: The objective of the study was to compare the diagnostic efficacy of an integrated Fluorine-18 fluorodeoxyglucose (F-18 FDG) PET/CT-mammography (mammo-PET/CT) with conventional torso PET/CT (supine-PET/CT) and MR-mammography for initial assessment of breast cancer patients.

Patients and methods: Forty women (52.0 ± 12.0 years) with breast cancer who underwent supine-PET/CT, mammo-PET/CT, and MR-mammography from April 2009 to August 2009 were enrolled in the study. We compared the size of the tumour, tumour to chest wall distance, tumour to skin distance, volume of axillary fossa, and number of meta-static axillary lymph nodes between supine-PET/CT and mammo-PET/CT. Next, we assessed the difference of focality of primary breast tumour and tumour size in mammo-PET/CT and MR-mammography. Histopathologic findings served as the standard of reference.

Results: In the comparison between supine-PET/CT and mammo-PET/CT, significant differences were found in the tumour size (supine-PET/CT: 1.3 ± 0.6 cm, mammo-PET/CT: 1.5 ± 0.6 cm, p < 0.001), tumour to thoracic wall distance (1.8 ± 0.9 cm, 2.2 ± 2.1 cm, p < 0.001), and tumour to skin distance (1.5 ± 0.8 cm, 2.1 ± 1.4 cm, p < 0.001). The volume of axillary fossa was significantly wider in mammo-PET/CT than supine-PET/CT (21.7 ± 8.7 cm(3) vs. 23.4 ± 10.4 cm(3), p = 0.03). Mammo-PET/CT provided more correct definition of the T-stage of the primary tumour than did supine-PET/CT (72.5% vs. 67.5%). No significant difference was found in the number of metastatic axillary lymph nodes. Compared with MR-mammography, mammo-PET/CT provided more correct classification of the focality of lesion than did MR-mammography (95% vs. 90%). In the T-stage, 72.5% of cases with mammo-PET/CT and 70% of cases with MR-mammography showed correspondence with pathologic results.

Conclusions: Mammo-PET/CT provided more correct definition of the T-stage and evaluation of axillary fossa may also be delineated more clearly than with supine-PET/CT. The initial assessment of mammo-PET/CT would be more useful than MR-mammography because the mammo-PET/CT indicates similar accuracy with MR-mammography for decision of T-stage of primary breast tumour and more correct than MR-mammography for defining focality of lesion.

No MeSH data available.


Related in: MedlinePlus