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Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.

Scelsi D, Mevio N, Bertino G, Occhini A, Brazzelli V, Morbini P, Benazzo M - Radiol Oncol (2013)

Bottom Line: The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy.The treatment of recurrent or advanced disease is still controversial.Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.

ABSTRACT

Background: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.

Case report: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.

Conclusions: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

No MeSH data available.


Related in: MedlinePlus

Follow up after four electrochemotherapy applications and 16 months.
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f4-rado-47-04-366: Follow up after four electrochemotherapy applications and 16 months.

Mentions: Due to the good response and tolerability of the procedure, two additional ECT treatments were performed during the following sixteen months, which resulted in a good local control of the tumour (Figure 4).


Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.

Scelsi D, Mevio N, Bertino G, Occhini A, Brazzelli V, Morbini P, Benazzo M - Radiol Oncol (2013)

Follow up after four electrochemotherapy applications and 16 months.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3814281&req=5

f4-rado-47-04-366: Follow up after four electrochemotherapy applications and 16 months.
Mentions: Due to the good response and tolerability of the procedure, two additional ECT treatments were performed during the following sixteen months, which resulted in a good local control of the tumour (Figure 4).

Bottom Line: The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy.The treatment of recurrent or advanced disease is still controversial.Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.

ABSTRACT

Background: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.

Case report: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.

Conclusions: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

No MeSH data available.


Related in: MedlinePlus