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Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.

Scelsi D, Mevio N, Bertino G, Occhini A, Brazzelli V, Morbini P, Benazzo M - Radiol Oncol (2013)

Bottom Line: The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy.The treatment of recurrent or advanced disease is still controversial.Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.

ABSTRACT

Background: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.

Case report: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.

Conclusions: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

No MeSH data available.


Related in: MedlinePlus

Reduction of 80% of the volume to the initial lesion after 2 treatments.
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Related In: Results  -  Collection

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f3-rado-47-04-366: Reduction of 80% of the volume to the initial lesion after 2 treatments.

Mentions: The patient was evaluated four weeks after the treatment: 50% reduction of the original tumour volume was observed, corresponding to a partial response according to RECIST criteria.6 The next ECT treatment resulted in 80% volume reduction compared to the original lesion (Figure 3).


Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.

Scelsi D, Mevio N, Bertino G, Occhini A, Brazzelli V, Morbini P, Benazzo M - Radiol Oncol (2013)

Reduction of 80% of the volume to the initial lesion after 2 treatments.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3814281&req=5

f3-rado-47-04-366: Reduction of 80% of the volume to the initial lesion after 2 treatments.
Mentions: The patient was evaluated four weeks after the treatment: 50% reduction of the original tumour volume was observed, corresponding to a partial response according to RECIST criteria.6 The next ECT treatment resulted in 80% volume reduction compared to the original lesion (Figure 3).

Bottom Line: The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy.The treatment of recurrent or advanced disease is still controversial.Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.

ABSTRACT

Background: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.

Case report: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.

Conclusions: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

No MeSH data available.


Related in: MedlinePlus