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Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.

Scelsi D, Mevio N, Bertino G, Occhini A, Brazzelli V, Morbini P, Benazzo M - Radiol Oncol (2013)

Bottom Line: The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy.The treatment of recurrent or advanced disease is still controversial.Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.

ABSTRACT

Background: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.

Case report: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.

Conclusions: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

No MeSH data available.


Related in: MedlinePlus

Before first electrochemotherapy: voluminous bluish lesion of the chin.
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f2-rado-47-04-366: Before first electrochemotherapy: voluminous bluish lesion of the chin.

Mentions: Two months after the treatment, mass in the area of previous surgery extending into a submandibular region was documented. A biopsy of the mass confirmed recurrent MCC (Figure 2). The re-operation was not an option because of the tumour extension, and radiotherapy was again refused by the patient. She was offered a palliative treatment with ECT. The treatment was performed according to the standard operating procedures of the ESOPE.5 Intravenous bleomycin infusion of 15.000 IU/m2 was administered eight minutes before delivery of electric pulses under general anaesthesia by means of a hexagonal electrode (length 25 mm) connected to a generator (Cliniporatorâ„¢ - IGEA srl, Carpi, [MO], Italy). The lesion with 1 cm tumour-free margin was treated by multiple direct insertions of the electrode. The pulses were completed within 28 minutes after the infusion of bleomycin.


Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.

Scelsi D, Mevio N, Bertino G, Occhini A, Brazzelli V, Morbini P, Benazzo M - Radiol Oncol (2013)

Before first electrochemotherapy: voluminous bluish lesion of the chin.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3814281&req=5

f2-rado-47-04-366: Before first electrochemotherapy: voluminous bluish lesion of the chin.
Mentions: Two months after the treatment, mass in the area of previous surgery extending into a submandibular region was documented. A biopsy of the mass confirmed recurrent MCC (Figure 2). The re-operation was not an option because of the tumour extension, and radiotherapy was again refused by the patient. She was offered a palliative treatment with ECT. The treatment was performed according to the standard operating procedures of the ESOPE.5 Intravenous bleomycin infusion of 15.000 IU/m2 was administered eight minutes before delivery of electric pulses under general anaesthesia by means of a hexagonal electrode (length 25 mm) connected to a generator (Cliniporatorâ„¢ - IGEA srl, Carpi, [MO], Italy). The lesion with 1 cm tumour-free margin was treated by multiple direct insertions of the electrode. The pulses were completed within 28 minutes after the infusion of bleomycin.

Bottom Line: The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy.The treatment of recurrent or advanced disease is still controversial.Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.

ABSTRACT

Background: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.

Case report: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.

Conclusions: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

No MeSH data available.


Related in: MedlinePlus