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Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.

Scelsi D, Mevio N, Bertino G, Occhini A, Brazzelli V, Morbini P, Benazzo M - Radiol Oncol (2013)

Bottom Line: The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy.The treatment of recurrent or advanced disease is still controversial.Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.

ABSTRACT

Background: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.

Case report: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.

Conclusions: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

No MeSH data available.


Related in: MedlinePlus

Tumour biopsy showing poorly differentiated cells with scarce cytoplasm and vesicular nuclei with inconspicuous nucleoli. High mitotic index and apoptotic figures were present. Immunohistochemical reactions were positive for cytokeratin 8 and 20 and neuroendocrine markers (chromogranin, synaptophysin and CD56/NCAM); TTF-1 was not expressed (H&E stain, 40×).
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f1-rado-47-04-366: Tumour biopsy showing poorly differentiated cells with scarce cytoplasm and vesicular nuclei with inconspicuous nucleoli. High mitotic index and apoptotic figures were present. Immunohistochemical reactions were positive for cytokeratin 8 and 20 and neuroendocrine markers (chromogranin, synaptophysin and CD56/NCAM); TTF-1 was not expressed (H&E stain, 40×).

Mentions: A 84 years old woman with hypertension, chronic vascular disease, chronic cardiac ischemia was admitted because of a dome-shaped bluish skin lesion in her chin of 2x2 cm, characterized by rapid growth. A skin biopsy showed poorly differentiated cells with scarce cytoplasm and vesicular nuclei with inconspicuous nucleoli. High mitotic index and apoptotic figures were present. Immunohistochemical reactions were positive for cytokeratin 8 and 20 and neuroendocrine markers chromogranin, synaptophysin and CD56/N-CAM; TTF-1 was not expressed. A diagnosis of MCC was established (Figure 1).


Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region.

Scelsi D, Mevio N, Bertino G, Occhini A, Brazzelli V, Morbini P, Benazzo M - Radiol Oncol (2013)

Tumour biopsy showing poorly differentiated cells with scarce cytoplasm and vesicular nuclei with inconspicuous nucleoli. High mitotic index and apoptotic figures were present. Immunohistochemical reactions were positive for cytokeratin 8 and 20 and neuroendocrine markers (chromogranin, synaptophysin and CD56/NCAM); TTF-1 was not expressed (H&E stain, 40×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3814281&req=5

f1-rado-47-04-366: Tumour biopsy showing poorly differentiated cells with scarce cytoplasm and vesicular nuclei with inconspicuous nucleoli. High mitotic index and apoptotic figures were present. Immunohistochemical reactions were positive for cytokeratin 8 and 20 and neuroendocrine markers (chromogranin, synaptophysin and CD56/NCAM); TTF-1 was not expressed (H&E stain, 40×).
Mentions: A 84 years old woman with hypertension, chronic vascular disease, chronic cardiac ischemia was admitted because of a dome-shaped bluish skin lesion in her chin of 2x2 cm, characterized by rapid growth. A skin biopsy showed poorly differentiated cells with scarce cytoplasm and vesicular nuclei with inconspicuous nucleoli. High mitotic index and apoptotic figures were present. Immunohistochemical reactions were positive for cytokeratin 8 and 20 and neuroendocrine markers chromogranin, synaptophysin and CD56/N-CAM; TTF-1 was not expressed. A diagnosis of MCC was established (Figure 1).

Bottom Line: The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy.The treatment of recurrent or advanced disease is still controversial.Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.

ABSTRACT

Background: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.

Case report: We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.

Conclusions: Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

No MeSH data available.


Related in: MedlinePlus