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Relationship between aspartate aminotransferase-to-platelet ratio index and carotid intima-media thickness in obese adolescents with non-alcoholic fatty liver disease.

Sert A, Pirgon O, Aypar E, Yılmaz H, Dündar B - J Clin Res Pediatr Endocrinol (2013)

Bottom Line: Fasting blood samples were assayed for transaminase, glucose, and insulin levels.This study demonstrated that a significant relationship exists between APRI and carotid IMT in obese adolescents with NAFLD.We suggest that an increased APRI score in obese adolescents with NAFLD can possibly serve to predict a more adverse cardiovascular risk profile.

View Article: PubMed Central - PubMed

Affiliation: Süleyman Demirel University, Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, Isparta, Turkey. E-mail: ozgurpirgon@gmail.com.

ABSTRACT

Objective: There is increasing evidence for an association between non-alcoholic fatty liver disease (NAFLD) and an increased risk of cardiovascular morbidity and mortality. The aim of this study was to investigate the association between aspartate aminotransferase-to-platelet ratio index (APRI) and carotid intima-media thickness (IMT) in obese adolescents with NAFLD.

Methods: Seventy-six obese adolescents and 36 lean subjects were enrolled in this cross-sectional single-centre study. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver with high transaminase levels (NAFLD group and non-NAFLD group). Fasting blood samples were assayed for transaminase, glucose, and insulin levels. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR).

Results: APRI values were higher in both obese groups (NAFLD and non-NAFLD) in comparison with the lean group. The NAFLD group had significantly higher APRI values than the non-NAFLD obese group and the lean group. Carotid IMT was higher in both obese groups (NAFLD and non-NAFLD) in comparison with the lean group. The NAFLD group had significantly higher measurements of carotid IMT than the non-NAFLD group and the lean group. APRI was positively correlated with most of the metabolic parameters (total cholesterol, low-density lipoprotein cholesterol, glucose, insulin, HOMA-IR) and with carotid IMT in the NAFLD obese group.

Conclusions: This study demonstrated that a significant relationship exists between APRI and carotid IMT in obese adolescents with NAFLD. We suggest that an increased APRI score in obese adolescents with NAFLD can possibly serve to predict a more adverse cardiovascular risk profile.

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Aspartate aminotransferase-to-platelet ratio index (APRI) in non-alcoholic fatty liver disease (NAFLD), non-NAFLD and lean groups
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f1: Aspartate aminotransferase-to-platelet ratio index (APRI) in non-alcoholic fatty liver disease (NAFLD), non-NAFLD and lean groups

Mentions: The lean group had lower HOMA-IR values than both the non-NAFLD and the NAFLD obese groups (0.73±0.29 vs. 3.73±2.95 vs. 5.50±3.35). Moreover, the NAFLD obese group had significantly higher APRI (0.342±0.073 vs. 0.200±0.075 vs. 0.149±0.038) and carotid IMT (0.458±0.043 vs. 0.377±0.017 vs. 0.359±0.012 mm) values than the non-NAFLD and the lean groups (Table 1) (Figure 1).


Relationship between aspartate aminotransferase-to-platelet ratio index and carotid intima-media thickness in obese adolescents with non-alcoholic fatty liver disease.

Sert A, Pirgon O, Aypar E, Yılmaz H, Dündar B - J Clin Res Pediatr Endocrinol (2013)

Aspartate aminotransferase-to-platelet ratio index (APRI) in non-alcoholic fatty liver disease (NAFLD), non-NAFLD and lean groups
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814245&req=5

f1: Aspartate aminotransferase-to-platelet ratio index (APRI) in non-alcoholic fatty liver disease (NAFLD), non-NAFLD and lean groups
Mentions: The lean group had lower HOMA-IR values than both the non-NAFLD and the NAFLD obese groups (0.73±0.29 vs. 3.73±2.95 vs. 5.50±3.35). Moreover, the NAFLD obese group had significantly higher APRI (0.342±0.073 vs. 0.200±0.075 vs. 0.149±0.038) and carotid IMT (0.458±0.043 vs. 0.377±0.017 vs. 0.359±0.012 mm) values than the non-NAFLD and the lean groups (Table 1) (Figure 1).

Bottom Line: Fasting blood samples were assayed for transaminase, glucose, and insulin levels.This study demonstrated that a significant relationship exists between APRI and carotid IMT in obese adolescents with NAFLD.We suggest that an increased APRI score in obese adolescents with NAFLD can possibly serve to predict a more adverse cardiovascular risk profile.

View Article: PubMed Central - PubMed

Affiliation: Süleyman Demirel University, Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, Isparta, Turkey. E-mail: ozgurpirgon@gmail.com.

ABSTRACT

Objective: There is increasing evidence for an association between non-alcoholic fatty liver disease (NAFLD) and an increased risk of cardiovascular morbidity and mortality. The aim of this study was to investigate the association between aspartate aminotransferase-to-platelet ratio index (APRI) and carotid intima-media thickness (IMT) in obese adolescents with NAFLD.

Methods: Seventy-six obese adolescents and 36 lean subjects were enrolled in this cross-sectional single-centre study. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver with high transaminase levels (NAFLD group and non-NAFLD group). Fasting blood samples were assayed for transaminase, glucose, and insulin levels. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR).

Results: APRI values were higher in both obese groups (NAFLD and non-NAFLD) in comparison with the lean group. The NAFLD group had significantly higher APRI values than the non-NAFLD obese group and the lean group. Carotid IMT was higher in both obese groups (NAFLD and non-NAFLD) in comparison with the lean group. The NAFLD group had significantly higher measurements of carotid IMT than the non-NAFLD group and the lean group. APRI was positively correlated with most of the metabolic parameters (total cholesterol, low-density lipoprotein cholesterol, glucose, insulin, HOMA-IR) and with carotid IMT in the NAFLD obese group.

Conclusions: This study demonstrated that a significant relationship exists between APRI and carotid IMT in obese adolescents with NAFLD. We suggest that an increased APRI score in obese adolescents with NAFLD can possibly serve to predict a more adverse cardiovascular risk profile.

Show MeSH
Related in: MedlinePlus