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Chlormadinone acetate is effective for hot flush during androgen deprivation therapy.

Koike H, Morikawa Y, Matsui H, Shibata Y, Ito K, Suzuki K - Prostate Int (2013)

Bottom Line: In patients with disappeared or improved symptoms, we decreased CMA dose to 50 mg per day, and after we reevaluated the effect, we decreased CMA dose to 25 mg per day.The effect of CMA was maintained at 25 mg per day in 19 patients and at 50 mg per day in 8 patients.No patients had prostate-specific antigen failure in the treatment of CMA.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.

ABSTRACT

Purpose: To investigate the clinical efficacy of low-dose chlormadinone acetate (CMA) in prostate cancer patients who suffer from hot flushes that is a major side effect of androgen deprivation therapy.

Methods: Our study included 32 prostate cancer patients who had severe hot flush after undergoing hormone therapy for more than 3 months. The average age of the patients was 72.5 years. In the beginning, patients received CMA at 100 mg orally per day. We defined the hot flush as disappeared, improved, or not improved. In patients with disappeared or improved symptoms, we decreased CMA dose to 50 mg per day, and after we reevaluated the effect, we decreased CMA dose to 25 mg per day. When hot flush appeared again at 25 mg per day, we returned the dose of CMA to 50 mg per day. In cases with no change for more than two months, we canceled the treatment of CMA.

Results: Hot flush disappeared in 17 patients, improved in 10 patients, and did not improve in 5 patients (reduction in 84% of hot flush patients). The median time to hot flush reduction was 1.16 months. The effect of CMA was maintained at 25 mg per day in 19 patients and at 50 mg per day in 8 patients. No patients had prostate-specific antigen failure in the treatment of CMA.

Conclusions: When hot flush appears during treatment with luteinizing hormone-releasing hormone agonist for prostate cancer, it seems that CMA can improve it immediately in most patients.

No MeSH data available.


Related in: MedlinePlus

The effect of chlormadine acetate (CMA).
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f1-pi-1-3-113-4: The effect of chlormadine acetate (CMA).

Mentions: Hot flush disappeared in 17 patients, was improved in 10 patients, was not improved in 5 patients (reduction in 84% of hot flush patients). The median time to hot flush reduction was 1.16 months. The effect of CMA was maintained at 25 mg per day in 19 patients and at 50 mg per day in 8 patients (Fig. 1). The role of ADT in the patients enrolled in this study and average duration of CMA in patients with response of CMA were shown in Table 2. No patients had PSA failure in the treatment of CMA. Adverse events were mild as shown in Table 3.


Chlormadinone acetate is effective for hot flush during androgen deprivation therapy.

Koike H, Morikawa Y, Matsui H, Shibata Y, Ito K, Suzuki K - Prostate Int (2013)

The effect of chlormadine acetate (CMA).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814123&req=5

f1-pi-1-3-113-4: The effect of chlormadine acetate (CMA).
Mentions: Hot flush disappeared in 17 patients, was improved in 10 patients, was not improved in 5 patients (reduction in 84% of hot flush patients). The median time to hot flush reduction was 1.16 months. The effect of CMA was maintained at 25 mg per day in 19 patients and at 50 mg per day in 8 patients (Fig. 1). The role of ADT in the patients enrolled in this study and average duration of CMA in patients with response of CMA were shown in Table 2. No patients had PSA failure in the treatment of CMA. Adverse events were mild as shown in Table 3.

Bottom Line: In patients with disappeared or improved symptoms, we decreased CMA dose to 50 mg per day, and after we reevaluated the effect, we decreased CMA dose to 25 mg per day.The effect of CMA was maintained at 25 mg per day in 19 patients and at 50 mg per day in 8 patients.No patients had prostate-specific antigen failure in the treatment of CMA.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.

ABSTRACT

Purpose: To investigate the clinical efficacy of low-dose chlormadinone acetate (CMA) in prostate cancer patients who suffer from hot flushes that is a major side effect of androgen deprivation therapy.

Methods: Our study included 32 prostate cancer patients who had severe hot flush after undergoing hormone therapy for more than 3 months. The average age of the patients was 72.5 years. In the beginning, patients received CMA at 100 mg orally per day. We defined the hot flush as disappeared, improved, or not improved. In patients with disappeared or improved symptoms, we decreased CMA dose to 50 mg per day, and after we reevaluated the effect, we decreased CMA dose to 25 mg per day. When hot flush appeared again at 25 mg per day, we returned the dose of CMA to 50 mg per day. In cases with no change for more than two months, we canceled the treatment of CMA.

Results: Hot flush disappeared in 17 patients, improved in 10 patients, and did not improve in 5 patients (reduction in 84% of hot flush patients). The median time to hot flush reduction was 1.16 months. The effect of CMA was maintained at 25 mg per day in 19 patients and at 50 mg per day in 8 patients. No patients had prostate-specific antigen failure in the treatment of CMA.

Conclusions: When hot flush appears during treatment with luteinizing hormone-releasing hormone agonist for prostate cancer, it seems that CMA can improve it immediately in most patients.

No MeSH data available.


Related in: MedlinePlus