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Effect of ivabradine on endothelial function in diastolic and right heart failure patients.

Orea-Tejeda A, Balderas-Muñoz K, Castillo-Martínez L, Infante-Vázquez O, Martínez Memije R, Keirns-Davis C, Dorantes-García J, Narváez-David R, Vázquez-Ortíz Z - Cardiol Res Pract (2013)

Bottom Line: Results.In the study group, the MAT/TT index was 29.1 ± 2.2 versus 24.3 ± 3.2 (P = 0.05) in basal recording and 30.4 ± 2.1 versus 23.3 ± 2.9 (P = 0.002), before versus after ischemia and before versus after Ivabradine intervention, respectively.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Heart Failure Clinic, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.

ABSTRACT
Background. Ivabradine is an If ion current inhibitor that has proved to reduce mortality in patients with systolic heart failure by slowing heart rate without decreasing myocardial contractility. Photoplethysmography is a simple, low-cost optical technique that can evaluate vascular function and detect changes in blood flow, pulse, and swelling of tissular microvascular space. Objective. To evaluate the effect of ivabradine on endothelial function by photoplethysmography in diastolic and right heart failure patients. Methodology. 15 patients were included (mean age of 78.1 ± 9.2 years) with optimally treated diastolic and right heart failure. They underwent photoplethysmography before and after induced ischemia to evaluate the wave blood flow on the finger, using the maximum amplitude time/total time (MAT/TT) index. Two measurements were made before and after oral Ivabradine (mean 12.5 mg a day during 6 months of followup). Results. In the study group, the MAT/TT index was 29.1 ± 2.2 versus 24.3 ± 3.2 (P = 0.05) in basal recording and 30.4 ± 2.1 versus 23.3 ± 2.9 (P = 0.002), before versus after ischemia and before versus after Ivabradine intervention, respectively. Conclusions. Ivabradine administration improves endothelial function (shear stress) in diastolic and right heart failure patients.

No MeSH data available.


Related in: MedlinePlus

Pre and after ischemic period, before and after 6 months of follow-up of oral ivabradine.
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fig1: Pre and after ischemic period, before and after 6 months of follow-up of oral ivabradine.

Mentions: Figure 1 shows the maximum amplitude time/total time (MAT/TT) index before and after the followup. A significant increase in pre- and post-ischemic periods after ivabradine administration is evident when basal values are compared with those at the end of followup.


Effect of ivabradine on endothelial function in diastolic and right heart failure patients.

Orea-Tejeda A, Balderas-Muñoz K, Castillo-Martínez L, Infante-Vázquez O, Martínez Memije R, Keirns-Davis C, Dorantes-García J, Narváez-David R, Vázquez-Ortíz Z - Cardiol Res Pract (2013)

Pre and after ischemic period, before and after 6 months of follow-up of oral ivabradine.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814108&req=5

fig1: Pre and after ischemic period, before and after 6 months of follow-up of oral ivabradine.
Mentions: Figure 1 shows the maximum amplitude time/total time (MAT/TT) index before and after the followup. A significant increase in pre- and post-ischemic periods after ivabradine administration is evident when basal values are compared with those at the end of followup.

Bottom Line: Results.In the study group, the MAT/TT index was 29.1 ± 2.2 versus 24.3 ± 3.2 (P = 0.05) in basal recording and 30.4 ± 2.1 versus 23.3 ± 2.9 (P = 0.002), before versus after ischemia and before versus after Ivabradine intervention, respectively.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Heart Failure Clinic, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.

ABSTRACT
Background. Ivabradine is an If ion current inhibitor that has proved to reduce mortality in patients with systolic heart failure by slowing heart rate without decreasing myocardial contractility. Photoplethysmography is a simple, low-cost optical technique that can evaluate vascular function and detect changes in blood flow, pulse, and swelling of tissular microvascular space. Objective. To evaluate the effect of ivabradine on endothelial function by photoplethysmography in diastolic and right heart failure patients. Methodology. 15 patients were included (mean age of 78.1 ± 9.2 years) with optimally treated diastolic and right heart failure. They underwent photoplethysmography before and after induced ischemia to evaluate the wave blood flow on the finger, using the maximum amplitude time/total time (MAT/TT) index. Two measurements were made before and after oral Ivabradine (mean 12.5 mg a day during 6 months of followup). Results. In the study group, the MAT/TT index was 29.1 ± 2.2 versus 24.3 ± 3.2 (P = 0.05) in basal recording and 30.4 ± 2.1 versus 23.3 ± 2.9 (P = 0.002), before versus after ischemia and before versus after Ivabradine intervention, respectively. Conclusions. Ivabradine administration improves endothelial function (shear stress) in diastolic and right heart failure patients.

No MeSH data available.


Related in: MedlinePlus