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Cellular debris in the anterior vitreous in silent eyes of behçet patients as a clue of asymptomatic ocular involvement.

Cingu AK, Türkcü FM, Yeniad B, Tugal-Tutkun L - J Ophthalmol (2013)

Bottom Line: Results.In Kaplan-Meier survival analysis there was a significant difference between the groups (group A 20.6% and group B 4.2%) by means of ocular involvement during their followup (log-rank = 6.85, P = 0.009).Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey.

ABSTRACT
Purpose. To investigate if there is a prognostic implication of the presence of cellular debris in the anterior vitreous in patients with Behçet's disease (BD) without any ocular symptoms. Methods. One hundred and twenty eyes of 60 patients with BD were included in the study. The eyes were divided into two groups according to the presence of cellular debris in the anterior vitreous. The first group included 54 eyes which were cellular debris (+) (group A), and the second group included 66 eyes which were cellular debris (-) (group B). Fluorescein angiography (FA) was performed to all patients following routine ocular examination. Patients were called for the six monthly control visits to investigate possible new ocular involvement during followup. The Kaplan-Meier method was used to estimate survival curves. Results. Seven eyes (13%) in group A and four eyes (6.1%) in group B showed optic disc hyperfluorescence on FA (P = 0.2). None of the eyes with disc hyperflourescence on initial examination developed uveitis attacks in their followup. In Kaplan-Meier survival analysis there was a significant difference between the groups (group A 20.6% and group B 4.2%) by means of ocular involvement during their followup (log-rank = 6.85, P = 0.009). Conclusions. Presence of cellular debris in the anterior vitreous may have prognostic implications in patients with BD screened for ocular involvement.

No MeSH data available.


Related in: MedlinePlus

(a) FA images of a patient showing optic disc hyperfluorescence and (b) a normal FA image of another patient. 
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fig1: (a) FA images of a patient showing optic disc hyperfluorescence and (b) a normal FA image of another patient. 

Mentions: Of the 60 patients, 30 were males and 30 were females. The mean age was 27.8 ± 7.8. Ocular examination revealed no pathologic findings in 28 patients. Cellular debris was seen in the anterior vitreous bilaterally in 22 patients and unilaterally in 10 patients. Thus, there were 54 eyes in the cellular debris (+) group and 66 eyes in the cellular debris (−) group. Seven eyes (13%) in group A and four eyes (6.1%) in group B demonstrated optic disc hyperfluorescence (staining of the disc) on FA at initial examination. There was no statistically significant difference between the two groups in optic disc hyperfluorescence (P = 0.2). Figure 1 shows FA images of two different patients, one having optic disc hyperfluorescence and the other being normal. There was no other angiographic abnormality in any eye in either group.


Cellular debris in the anterior vitreous in silent eyes of behçet patients as a clue of asymptomatic ocular involvement.

Cingu AK, Türkcü FM, Yeniad B, Tugal-Tutkun L - J Ophthalmol (2013)

(a) FA images of a patient showing optic disc hyperfluorescence and (b) a normal FA image of another patient. 
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814101&req=5

fig1: (a) FA images of a patient showing optic disc hyperfluorescence and (b) a normal FA image of another patient. 
Mentions: Of the 60 patients, 30 were males and 30 were females. The mean age was 27.8 ± 7.8. Ocular examination revealed no pathologic findings in 28 patients. Cellular debris was seen in the anterior vitreous bilaterally in 22 patients and unilaterally in 10 patients. Thus, there were 54 eyes in the cellular debris (+) group and 66 eyes in the cellular debris (−) group. Seven eyes (13%) in group A and four eyes (6.1%) in group B demonstrated optic disc hyperfluorescence (staining of the disc) on FA at initial examination. There was no statistically significant difference between the two groups in optic disc hyperfluorescence (P = 0.2). Figure 1 shows FA images of two different patients, one having optic disc hyperfluorescence and the other being normal. There was no other angiographic abnormality in any eye in either group.

Bottom Line: Results.In Kaplan-Meier survival analysis there was a significant difference between the groups (group A 20.6% and group B 4.2%) by means of ocular involvement during their followup (log-rank = 6.85, P = 0.009).Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey.

ABSTRACT
Purpose. To investigate if there is a prognostic implication of the presence of cellular debris in the anterior vitreous in patients with Behçet's disease (BD) without any ocular symptoms. Methods. One hundred and twenty eyes of 60 patients with BD were included in the study. The eyes were divided into two groups according to the presence of cellular debris in the anterior vitreous. The first group included 54 eyes which were cellular debris (+) (group A), and the second group included 66 eyes which were cellular debris (-) (group B). Fluorescein angiography (FA) was performed to all patients following routine ocular examination. Patients were called for the six monthly control visits to investigate possible new ocular involvement during followup. The Kaplan-Meier method was used to estimate survival curves. Results. Seven eyes (13%) in group A and four eyes (6.1%) in group B showed optic disc hyperfluorescence on FA (P = 0.2). None of the eyes with disc hyperflourescence on initial examination developed uveitis attacks in their followup. In Kaplan-Meier survival analysis there was a significant difference between the groups (group A 20.6% and group B 4.2%) by means of ocular involvement during their followup (log-rank = 6.85, P = 0.009). Conclusions. Presence of cellular debris in the anterior vitreous may have prognostic implications in patients with BD screened for ocular involvement.

No MeSH data available.


Related in: MedlinePlus